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Last Updated: March 28, 2024

Claims for Patent: 9,539,262


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Summary for Patent: 9,539,262
Title:Ophthalmic composition comprising a prostaglandin
Abstract: The present invention relates to a pharmaceutical composition suitable for ophthalmic use comprising one or more prostaglandin derivatives or salts, a stabilizing amount of polyethylene glycol hydroxystearate and pharmaceutically acceptable vehicle.
Inventor(s): Khopade; Ajay Jaysingh (Baroda, IN), Halder; Arindam (Baroda, IN), Bhowmick; Subhas Balaram (Baroda, IN)
Assignee: SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (Mumbai, IN)
Application Number:14/691,167
Patent Claims: 1. A method of reducing intraocular pressure comprising a step of administering an ophthalmic composition comprising 0.005% w/v latanoprost or a pharmaceutically acceptable salt thereof, 0.15% to 0.3% w/v castor oil, 0.2 to 0.75% w/v of polyethylene glycol hydroxystearate, and a pharmaceutically acceptable vehicle, wherein the ratio of oil to polyethylene glycol hydroxystearate is less than 1.0, wherein the composition is in the form of a self-emulsifying micro-emulsion with average droplet size of about 100 nm or less and a zeta potential is between -0.1 mV to -20 mV, wherein the composition does not comprise a cationic surfactant, and wherein the composition does not comprise a quaternary ammonium compound.

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