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Last Updated: March 28, 2024

Claims for Patent: 9,533,102


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Summary for Patent: 9,533,102
Title:Prefilled syringe jet injector
Abstract: A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site.
Inventor(s): Lesch, Jr.; Paul R. (Lino Lakes, MN)
Assignee: Antares Pharma, Inc. (Ewing, NJ)
Application Number:14/930,689
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 9,533,102
Patent Claims: 1. A jet injector, comprising: a prefilled syringe comprising: a container portion defining a fluid chamber containing a medicament; an injection-assisting needle disposed at the distal end of the chamber, having an injecting tip configured for piercing an insertion location, and defining a fluid pathway in fluid communication with the chamber for injecting the fluid from the chamber into an injection site; a plunger movable within the fluid chamber; and a housing that houses the prefilled syringe and is configured for allowing insertion of the needle at the injection location to an insertion point that is at a penetration depth below the surface at the insertion location; a syringe support supportively mounting the prefilled syringe to the housing; and an energy source configured for biasing the plunger with a force selected to produce an injecting pressure in the medicament in the fluid chamber that substantially remains between about 80 p.s.i. and 1000 p.s.i. during injection of the medicament to jet inject the medicament from the fluid chamber through the needle to the injection site; wherein the penetration depth and injecting pressure are sufficient to substantially prevent backflow of the injected medicament.

2. The jet injector of claim 1, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains below about 500 p.s.i. and above about 90 p.s.i. during the injection of the medicament.

3. The jet injector of claim 1, wherein the energy source is configured to produce the injecting pressure that remains at least at about 100 p.s.i. during the injection of the medicament.

4. The jet injector of claim 3, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains up to about 350 p.s.i. during the injection of the medicament.

5. The jet injector of claim 1, wherein the housing is configured for allowing insertion of the needle to the penetration depth, which is between about 0.5 mm and 5 mm below the surface at the insertion location.

6. The jet injector of claim 1, wherein the housing is configured for allowing insertion of the needle to the penetration depth, which is between about 11 mm and 13 mm below the surface at the insertion location.

7. The jet injector of claim 1, wherein the energy source comprises a spring.

8. The jet injector of claim 1, further comprising a ram that is biased by the spring against the plunger to produce the injecting pressure, wherein the ram comprises a bell portion on which the spring is seated, and the bell portion defines a hollow interior configured for receiving the prefilled syringe when the device is fired, such that the spring surrounds the prefilled syringe.

9. The jet injector of claim 1, wherein: the prefilled syringe has a distal portion in which the injection-assisting needle is located, and a proximal portion opposite the distal portion; and the syringe support axially supports the proximal portion of the pre-filled syringe during the jet injection of the medicament, such that the distal portion of the prefilled syringe is substantially unsupported in an axial direction.

10. The jet injector of claim 9, wherein the container portion of the pre-filled syringe is made of blown glass.

11. The jet injector of claim 10, wherein the injection-assisting needle is adhered to the glass.

12. The jet injector of claim 1, wherein the chamber contains about 0.02 mL and 4 mL of the medicament.

13. The jet injector of claim 1, wherein the housing comprises a retractable guard that is movable between: a protecting position in which the needle is disposed within the guard; and an injecting position in which the tip of the needle is exposed for insertion to an insertion point.

14. The jet injector of claim 13, further comprising a trigger mechanism operably associated with the energy source for activating the energy source to jet inject the medicament, wherein the trigger mechanism is configured for activating the energy source after the retractable guard is retracted from the protecting position.

15. The jet injector of claim 14, wherein the retractable guard is operably associated with the trigger mechanism to cause the trigger mechanism to activate the energy source when the guard is retracted to the injecting position.

16. The jet injector of claim 1, further comprising a syringe cushion associated with the syringe support and prefilled syringe to compensate for shape.

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