You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 28, 2024

Claims for Patent: 9,526,726


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 9,526,726
Title:Aripiprazole formulations having increased injection speeds
Abstract: The present invention relates to pharmaceutical compositions comprising a compound of Formula (I) that are useful for the intramuscular delivery of antipsychotic drugs using rapid injection rates.
Inventor(s): Hickey; Magali B. (Westwood, MA), Vandiver; Jennifer (Arlington, MA)
Assignee: ALKERMES PHARMA IRELAND LIMITED (Dublin, IE)
Application Number:15/164,473
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 9,526,726
Patent Claims: 1. A kit for the treatment of schizophrenia, wherein the kit comprises a therapeutically effective amount of a pharmaceutical composition and further comprises instructions for intramuscular injection, wherein the instructions specify a continuous intramuscular injection within 10 seconds, wherein said pharmaceutical composition comprises: (a) 24-30 weight percent Compound 1: ##STR00048## (b) 0.3-0.4 weight percent sorbitan laurate; (c) 0.1-0.3 weight percent polysorbate 20; and (d) an aqueous vehicle wherein the percentages of (a), (b), and (c) are relative to the total weight of the composition; wherein the pharmaceutical composition has a total injection volume of approximately 3.2 mL.

2. The kit according to claim 1, wherein the said pharmaceutical composition comprises: (a) about 26.6 weight percent Compound 1: ##STR00049## (b) about 0.37 weight percent sorbitan laurate; (c) about 0.15 weight percent polysorbate 20; and (d) an aqueous vehicle wherein the percentages of (a), (b), and (c) are relative to the total weight of the composition.

3. The kit according to claim 1, wherein the administration is instantaneous.

4. The kit according to claim 1, wherein the kit further comprises a 20 to 23 gauge needle.

5. The kit according to claim 4, wherein the needle is a 20 gauge needle.

6. The kit according to claim 1, wherein the injection is administered to the subject in the dorsal gluteal muscle.

7. The kit of claim 1, wherein the kit further comprises a container for containing the pharmaceutical composition.

8. The kit of claim 7, wherein the container is a prefilled syringe.

9. A kit for the treatment of schizophrenia, wherein the kit comprises a therapeutically effective amount of a pharmaceutical composition and further comprises instructions for intramuscular injection, wherein the instructions specify a continuous intramuscular injection within 10 seconds, wherein said pharmaceutical composition comprises: (a) 24-30 weight percent Compound 1: ##STR00050## (b) 0.3-0.4 weight percent sorbitan laurate; (c) 0.1-0.3 weight percent polysorbate 20; and (d) an aqueous vehicle wherein the percentages of (a), (b), and (c) are relative to the total weight of the composition; and wherein the pharmaceutical composition has a total injection volume of approximately 2.4 mL.

10. The kit of claim 9, wherein the said pharmaceutical composition comprises: (a) about 26.6 weight percent Compound 1: ##STR00051## (b) about 0.37 weight percent sorbitan laurate; (c) about 0.15 weight percent polysorbate 20; and (d) an aqueous vehicle wherein the percentages of (a), (b), and (c) are relative to the total weight of the composition.

11. The kit according to claim 9, wherein the administration is instantaneous.

12. The kit according to claim 9, wherein the kit further comprises a 20 to 23 gauge needle.

13. The kit according to claim 12, wherein the needle is a 20 gauge needle.

14. The kit according to claim 9, wherein the injection is administered to the subject in the dorsal gluteal muscle.

15. The kit of claim 9, wherein the kit further comprises a container for containing the pharmaceutical composition.

16. The kit of claim 15, wherein the container is a prefilled syringe.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.