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Last Updated: March 28, 2024

Claims for Patent: 9,512,107


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Summary for Patent: 9,512,107
Title:Therapeutically active compositions and their methods of use
Abstract: Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
Inventor(s): Cianchetta; Giovanni (Waltham, MA), DeLaBarre; Byron (Arlington, MA), Popovici-Muller; Janeta (Waltham, MA), Salituro; Francesco G. (Marlborough, MA), Saunders; Jeffrey O. (Lincoln, MA), Travins; Jeremy (Southborough, MA), Yan; Shunqi (Irvine, CA), Guo; Tao (Dayton, NJ), Zhang; Li (Shanghai, CN)
Assignee: Agios Pharmaceuticals, Inc. (Cambridge, MA)
Application Number:15/173,519
Patent Claims: 1. A compound which is ##STR01131## or a pharmaceutically acceptable salt or hydrate thereof.

2. The compound of claim 1, wherein the compound is ##STR01132##

3. A pharmaceutical composition comprising a compound of claim 1, and a pharmaceutically acceptable carrier.

4. A method of treating a cancer characterized by the presence of an IDH2 mutation, wherein the IDH2 mutation results in a new ability of the enzyme to catalyze the NAPH dependent reduction of .alpha. ketoglutarate to R(-) 2 hydroxyglutarate in a patient, comprising the step of administering to the patient in need thereof a compound of claim 1.

5. The method of claim 4, wherein the IDH2 mutation is an IDH2 R140Q or R172K mutation.

6. The method of claim 4, wherein the IDH2 mutation is an IDH2 R140Q mutation.

7. The method of claim 4, wherein the cancer is selected from glioblastoma, myelodysplastic syndrome, myeloproliferative neoplasm, acute myelogenous leukemia, sarcoma, melanoma, non small cell lung cancer, chondrosarcoma, cholangiocarcinomas or angioimmunoblastic non-Hodgkin's lymphoma.

8. The method of claim 4, wherein the cancer is acute myelogenous leukemia.

9. The method of claim 4, further comprising administering to the patient in need thereof a second therapeutic agent useful in the treatment of cancer.

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