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Last Updated: January 30, 2026

Claims for Patent: 9,474,746

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Summary for Patent: 9,474,746

Title:	Methods for stabilizing oxidatively unstable compositions
Abstract:	Ophthalmic compositions and methods of preparing such compositions are disclosed.
Inventor(s):	Shivkumar Mahadevan, Frank Molock, Vandeeta Khanolkar
Assignee:	Johnson and Johnson Vision Care Inc
Application Number:	US13/894,482
Patent Claims:	1. An ophthalmic composition comprising a liquid, aerosol or gel which comprises, and an oxidatively unstable pharmaceutical ingredient selected from the group consisting of ketotifen, its pharmaceutically acceptable salts, nor ketotifen fumarate, and mixtures thereof and an effective amount of a stabilizing agent selected from the group consisting of diethylenetriaminepentaacetic acid and salts of diethylenetriaminepentaacetic acid wherein the ophthalmic composition has a pH of 6.6 to 7.2. 2. The ophthalmic composition of claim 1 wherein the effective amount of the stabilizing agent is about 2.5 μmoles/liter to about 5000 μmoles/liter. 3. The ophthalmic composition of claim 1 wherein the effective amount of the stabilizing agent is about 100 μmoles/liter to about 1000 μmoles/liter. 4. The ophthalmic composition of claim 1 wherein the effective amount of the stabilizing agent is about 100 μmoles/liter to about 600 μmoles/liter. 5. The ophthalmic composition of claim 1 wherein the stabilizing agent is diethylenetriaminepentaacetic acid. 6. The ophthalmic composition of claim 1 wherein the oxidatively unstable pharmaceutical ingredient is selected from the group consisting of ketotifen, its pharmaceutically acceptable salts, and mixtures thereof.

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