Claims for Patent: 9,464,071

Summary for Patent: 9,464,071

Title:	Pyrazolyl quinoxaline kinase inhibitors
Abstract:	The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Inventor(s):	Gordon Saxty, Christopher William Murray, Valerio Berdini, Gilbert Ebai Besong, Christopher Charles Frederick Hamlett, Christopher Norbert Johnson, Steven John Woodhead, Michael Reader, David Charles Rees, Laurence Anne Mevellec, Patrick René Angibaud, Eddy Jean Edgard Freyne, Tom Cornelis Hortense Govaerts, Johan Erwin Edmond Weerts, Timothy Pietro Suren Perera, Ronaldus Arnodus Hendrika Joseph Gilissen, Berthold Wroblowski, Jean Fernand Armand Lacrampe, Alexandra Papanikos, Olivier Alexis Georges Querolle, Elisabeth Thérèse Jeanne Pasquier, Isabelle Noëlle Constance Pilatte, Pascal Ghislain André Bonnet, Werner Constant Johan Embrechts, Rhalid Akkari, Lieven Meerpoel
Assignee:	Janssen Pharmaceutica NV, Astex Therapeutics Ltd
Application Number:	US14/505,020
Patent Claims:	1. A method for treating a subject suffering from a disease state or condition mediated by a FGFR kinase, said method comprising administering to the subject a compound selected from the group consisting of a compound of formula (I) a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein n is an integer equal to 0, 1, 2, 3 or 4; R1 is hydrogen, C1-6alkyl, C2-4alkenyl, hydroxyC1-6alkyl, haloC1-6alkyl, hydroxyhaloC1-6alkyl, cyanoC1-4alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, C1-6alkyl substituted with —NR4R5, C1-6alkyl substituted with —C(═O)—NR4R5, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —NR12—S(═O)2—NR14R15, R6, C1-6alkyl substituted with R6, C1-6alkyl substituted with —C(═O)—R6, hydroxyC1-6alkyl substituted with R6, C1-6alkyl substituted with —Si(CH3)3, C1-6alkyl substituted with —P(═O)(OH)2 or C1-6alkyl substituted with —P(═O)(OC1-6alkyl)2; each R1a is independently selected from hydrogen, C1-4alkyl, hydroxyC1-4alkyl, C1-4alkyl substituted with amino or mono- or di(C1-4alkyl)amino or —NH(C3-8cycloalkyl), cyanoC1-4alkyl, C1-4alkoxyC1-4alkyl, and C1-4alkyl substituted with one or more fluoro atoms; each R2 is independently selected from hydroxyl, halogen, cyano, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy, hydroxyC1-4alkyl, hydroxyC1-4alkoxy, haloC1-4alkyl, haloC1-4alkoxy, hydroxyhaloC1-4alkyl, hydroxyhaloC1-4alkoxy, C1-4alkoxyC1-4alkyl, haloC1-4alkoxyC1-4alkyl, C1-4alkoxyC1-4alkyl wherein each C1-4alkyl is optionally substituted with one or two hydroxyl groups, hydroxyhaloC1-4alkoxyC1-4alkyl, R13, C1-4alkyl substituted with R13, C1-4alkyl substituted with —C(═O)—R13, C1-4alkoxy substituted with R13, C1-4alkoxy substituted with —C(═O)—R13, —C(═O)—R13, C1-4alkyl substituted with —NR7R8, C1-4alkyl substituted with —C(═O)—NR7R8, C1-4alkoxy substituted with —NR7R8, C1-4alkoxy substituted with —C(═O)—NR7R8, —NR7R8 and —C(═O)—NR7R8; or when two R2 groups are attached to adjacent carbon atoms they are optionally taken together to form a radical of formula: —O—(C(R17)2)p—O—; —X—CH═CH—; or —X—CH═N—; wherein R17 is hydrogen or fluorine, p is 1 or 2 and X is O or S; R3 is hydroxyl, C1-6alkoxy, hydroxyC1-6alkoxy, C1-6alkoxy substituted with —NR10R11, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, haloC1-6alkyl optionally substituted with —O—C(═O)—C1-6alkyl, hydroxyC1-6alkyl optionally substituted with —O—C(═O)—C1-6alkyl, hydroxyC2-6alkenyl, hydroxyC2-6alkynyl, hydroxyhaloC1-6alkyl, cyanoC1-6alkyl, C1-6alkyl substituted with carboxyl, C1-6alkyl substituted with —C(═O)—C1-6alkyl, C1-6alkyl substituted with —C(═O)—O—C1-6alkyl, C1-6alkyl substituted with C1-6alkoxyC1-6alkyl-O—C(═O)—, C1-6alkyl substituted with C1-6alkoxyC1-6alkyl-C(═O)—, C1-6alkyl substituted with —O—C(═O)—C1-6alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups or with —O—C(═O)—C1-6alkyl, C2-6alkenyl substituted with C1-6alkoxy, C2-6alkynyl substituted with C1-6alkoxy, C1-6alkyl substituted with R9 and optionally substituted with —O—C(═O)—C1-6alkyl, C1-6alkyl substituted with —C(═O)—R9, C1-6alkyl substituted with hydroxyl and R9, C2-6alkenyl substituted with R9, C2-6alkynyl substituted with R9, C1-6alkyl substituted with —NR10R11, C2-6alkenyl substituted with —NR10R11, C2-6alkynyl substituted with —NR10R11, C1-6alkyl substituted with hydroxyl and —NR10R11, C1-6alkyl substituted with one or two halogens and —NR10R11, —C1-6alkyl-C(R12)═N—O—R12, C1-6alkyl substituted with —C(═O)—NR10R11, C1-6alkyl substituted with —O—C(═O)—NR10R11, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NR12—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —NR12—S(═O)2—NR14R15, R13, C1-6alkyl substituted with —P(═O)(OH)2 or C1-6alkyl substituted with —P(═O)(OC1-6alkyl)2; R4 and R5 are each independently hydrogen, C1-6alkyl, hydroxyC1-6alkyl, haloC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2—NR14R15, R13 or C1-6alkyl substituted with R13; R6 is C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, 4 to 7-membered monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S; said C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, 4 to 7-membered monocyclic heterocyclyl, each optionally and each independently substituted by 1, 2, 3, 4 or 5 substituents, each substituent independently selected from cyano, C1-6alkyl, cyanoC1-6alkyl, hydroxyl, carboxyl, hydroxyC1-6alkyl, halogen, haloC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6alkyl-O—C(═O)—, —NR14R15, —C(═O)—NR14R15, C1-6alkyl substituted with —NR14R15, C1-6alkyl substituted with —C(═O)—NR14R15, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl and C1-6alkyl substituted with —NH—S(═O)2—NR14R15; R7 and R8 are each independently hydrogen, C1-6alkyl, hydroxyC1-6alkyl, haloC1-6alkyl, hydroxyhaloC1-6alkyl or C1-6alkoxyC1-6alkyl; R9 is C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, naphthyl, or 3 to 12 membered monocyclic or bicyclic heterocyclyl containing at least one heteroatom selected from N, O and S, said C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, naphthyl, or 3 to 12 membered monocyclic or bicyclic heterocyclyl each optionally and each independently substituted with 1, 2, 3, 4 or 5 substituents, each substituent independently selected from ═O, C1-4alkyl, hydroxyl, carboxyl, hydroxyC1-4alkyl, cyano, cyanoC1-4alkyl, C1-4alkyl-O—C(═O)—, C1-4alkyl substituted with C1-4alkyl-O—C(═O)—, C1-4alkyl-C(═O)—, C1-4alkoxyC1-4alkyl wherein each C1-4alkyl is optionally substituted with one or two hydroxyl groups, halogen, haloC1-4alkyl, hydroxyhaloC1-4alkyl, —NR14R15, —C(═O)—NR14R15, —C1-4alkyl substituted with —NR14R15, C1-4alkyl substituted with —C(═O)—NR14R15, C1-4alkoxy, —S(═O)2—C1-4alkyl, —S(═O)2-haloC1-4alkyl, —S(═O)2—NR14R15, C1-4alkyl substituted with —S(═O)2—NR14R15, C1-4alkyl substituted with —NH—S(═O)2—C1-4alkyl, C1-4alkyl substituted with —NH—S(═O)2-haloC1-4alkyl, C1-4alkyl substituted with —NH—S(═O)2—NR14R15, R13, —C(═O)—R13, C1-4alkyl substituted with R13, phenyl optionally substituted with R16, phenylC1-6alkyl wherein the phenyl is optionally substituted with R16, and a 5 or 6-membered aromatic monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S wherein said heterocyclyl is optionally substituted with R16; or when two of the substituents of R9 are attached to the same atom, they are optionally taken together to form a 4 to 7-membered saturated monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S; R10 and R11 are each independently hydrogen, carboxyl, C1-6alkyl, cyanoC1-6alkyl, C1-6alkyl substituted with —NR14R15, C1-6alkyl substituted with —C(═O)—NR14R15, haloC1-6alkyl, hydroxyC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, R6, C1-6alkyl substituted with R6, —C(═O)—R6, —C(═O)—C1-6alkyl, —C(═O)-hydroxyC1-6alkyl, —C(═O)-haloC1-6alkyl, —C(═O)-hydroxyhaloC1-6alkyl, C1-6alkyl substituted with —Si(CH3)3, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl or C1-6alkyl substituted with —NH—S(═O)2—NR14R15; R12 is hydrogen or C1-4alkyl optionally substituted with C1-4alkoxy; R13 is C3-8cycloalkyl or a saturated 4 to 6-membered monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S, wherein said C3-8cycloalkyl or monocyclic heterocyclyl is optionally substituted with 1, 2 or 3 substituents each independently selected from halogen, hydroxyl, C1-6alkyl, —C(═O)—C1-6alkyl, C1-6alkoxy, and —NR14R15; R14 and R15 are each independently hydrogen, or haloC1-4alkyl, or C1-4alkyl optionally substituted with a substituent selected from hydroxyl, C1-4alkoxy, amino and mono- or di(C1-4alkyl)amino; and R16 is hydroxyl, halogen, cyano, C1-4alkyl, C1-4alkoxy, —NR14R15 or —C(═O)NR14R15; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 2. A method according to claim 1, wherein the compound is selected from the group consisting of a compound of formula (I), a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein R1 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, haloC1-6alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, C1-6alkyl substituted with —NR4R5, C1-6alkyl substituted with —C(═O)—NR4R5, —S(═O)2—C1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, R6, C1-6alkyl substituted with R6, C1-6alkyl substituted with —C(═O)—R6, hydroxyC1-6alkyl substituted with R6, or C1-6alkyl substituted with —Si(CH3)3; each R1a is hydrogen; R10 and R11 are each independently hydrogen, C1-6alkyl, cyanoC1-6alkyl, C1-6alkyl substituted with —NR14R15, C1-6alkyl substituted with —C(═O)—NR14R15, haloC1-6alkyl, hydroxyC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, R6, C1-6alkyl substituted with R6, —C(═O)—R6, —C(═O)—C1-6alkyl, —C(═O)-hydroxyC1-6alkyl, —C(═O)-haloC1-6alkyl, —C(═O)-hydroxyhaloC1-6alkyl, C1-6alkyl substituted with —Si(CH3)3, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl or C1-6alkyl substituted with —NH—S(═O)2—NR14R15; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 3. A method according to claim 1, wherein the compound is selected from the group consisting of a compound of formula (I), a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein each R1a is hydrogen; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 4. A method according to claim 1, wherein the compound is selected from the group consisting of a compound of formula (I), a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein R1 is C1-6alkyl; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 5. A method according to claim 1, wherein the compound is selected from the group consisting of a compound of formula (I), a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein R1 is CH3— or CD3-; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 6. A method according to claim 1, wherein the compound is selected from the group consisting of a compound of formula (I), a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein R2 is independently selected from halogen, cyano, C1-4alkyl, C2-4alkenyl, C1-4alkoxy, hydroxyC1-4alkyl, hydroxyC1-4alkoxy, haloC1-4alkoxy, C1-4alkoxyC1-4alkyl, R13, C1-4alkoxy substituted with R13, —C(═O)—R13, C1-4alkyl substituted with NR7R8, C1-4alkoxy substituted with NR7R8, —NR7R8 and —C(═O)—NR7R8; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 7. A method according to claim 6, wherein the compound is selected from the group consisting of a compound of formula (I), a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein R2 is C1-4alkoxy; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 8. A method according to claim 6, wherein the compound is selected from the group consisting of a compound of formula (I), a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein R2 is CH3O— or CD3O—; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 9. A method according to claim 1, wherein the compound is selected from the group consisting of a compound of formula (I), a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein R3 is C1-6alkyl, hydroxyC1-6alkyl, hydroxyhaloC1-6alkyl, haloC1-6alkyl, C1-6alkyl substituted with —C(═O)—C1-6alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, C1-6alkyl substituted with R9, C1-6alkyl substituted with —NR10R11, C1-6alkyl substituted with hydroxyl and —NR10R11, C1-6alkyl substituted with one or two halogens and —NR10R11, C1-6alkyl substituted with —C(═O)—O—C1-6alkyl, C1-6alkyl substituted with —O—C(═O)—NR10R11, C1-6alkyl substituted with carboxyl, C1-6alkyl substituted with —NR12—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NR12—S(═O)2—NR14R15, C1-6alkyl substituted with hydroxyl and R9, —C1-6alkyl-C(R12)═N—O—R12, C1-6alkyl substituted with —C(═O)—NR10R11, C1-6alkyl substituted with —C(═O)—R9, C2-6alkynyl substituted with R9, hydroxyC1-6alkoxy, C2-6alkenyl, C2-6alkynyl or R13; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 10. A method according to claim 1, wherein the compound is selected from the group consisting of a compound of formula (I), a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein R1 is C1-6alkyl, each R1a is hydrogen, n is an integer equal to 2, each R2 is C1-4alkoxy, and R3 is C1-6alkyl substituted with —NR10R11; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 11. A method according to claim 10, wherein the compound is selected from the group consisting of a compound of formula (I), a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein R10 is hydrogen, —CH3, —CH2CH3 or —CH(CH3)2 and R11 is hydrogen, —CH3, —CH2CH3, —CH(CH3)2, —CH2CF3, —CH2CHF2, —CH2CH2F, —C(═O)—CH3, —S(═O)2—CH3, —S(═O)2—CH2CH3, —S(═O)2—CH(CH3)2, —S(═O)2—N(CH3)2, —CH2CH2OH, —C(═O)—C(OH)(CH3)CF3, —C(═O)-cyclopropyl, —CH2CH2CN, cyclopropane, cyclopentane, 2,2,6,6-tetramethyl-piperidine, —CH2C3H5, —CH2— tetrahydrofuran, —C(═O)-(1-methyl-piperidin-3-yl), —C(═O)—CF3, —CH2Si(CH3)3, or —CH2—C6H5; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 12. A method according to claim 10, wherein the compound is selected from the group consisting of a compound of formula (I), a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein R1 is —CH3, each R1a is hydrogen, n is an integer equal to 2, each R2 is CH3O—, and R3 is —CH2CH2NHCH(CH3)2; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 13. A method according to claim 10, wherein the compound is selected from the group consisting of a compound of formula (I), a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein R1 is —CH3, each R1a is hydrogen, n is an integer equal to 2, each R2 is CH3O—, and R3 is —CH2CH2—CH2—NHCH2CF3 or —CH2—CH2NH2; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 14. A method according to claim 1, wherein the compound is N-(3,5-dimethoxyphenyl)-N′-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 15. A method according to claim 14, wherein the compound is N-(3,5-dimethoxyphenyl)-N′-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine. 16. A method according to claim 1, wherein the compound is selected from: N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]-N′-(2,2,2-trifluoroethyl)propane-1,3-diamine; and N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 17. A method according to claim 16, wherein the compound is selected from: N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]-N′-(2,2,2-trifluoroethyl)propane-1,3-diamine; and N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine. 18. A method for treating a subject suffering from cancer, said method comprising administering to the subject a compound selected from the group consisting of a compound of formula (I) a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein n is an integer equal to 0, 1, 2, 3 or 4; R1 is hydrogen, C1-6alkyl, C2-4alkenyl, hydroxyC1-6alkyl, haloC1-6alkyl, hydroxyhaloC1-6alkyl, cyanoC1-4alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, C1-6alkyl substituted with —NR4R5, C1-6alkyl substituted with —C(═O)—NR4R5, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —NR12—S(═O)2—NR14R15, R6, C1-6alkyl substituted with R6, C1-6alkyl substituted with —C(═O)—R6, hydroxyC1-6alkyl substituted with R6, C1-6alkyl substituted with —Si(CH3)3, C1-6alkyl substituted with —P(═O)(OH)2 or C1-6alkyl substituted with —P(═O)(OC1-6alkyl)2; each R1a is independently selected from hydrogen, C1-4alkyl, hydroxyC1-4alkyl, C1-4alkyl substituted with amino or mono- or di(C1-4alkyl)amino or —NH(C3-8cycloalkyl), cyanoC1-4alkyl, C1-4alkoxyC1-4alkyl, and C1-4alkyl substituted with one or more fluoro atoms; each R2 is independently selected from hydroxyl, halogen, cyano, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy, hydroxyC1-4alkyl, hydroxyC1-4alkoxy, haloC1-4alkyl, haloC1-4alkoxy, hydroxyhaloC1-4alkyl, hydroxyhaloC1-4alkoxy, C1-4alkoxyC1-4alkyl, haloC1-4alkoxyC1-4alkyl, C1-4alkoxyC1-4alkyl wherein each C1-4alkyl is optionally substituted with one or two hydroxyl groups, hydroxyhaloC1-4alkoxyC1-4alkyl, R13, C1-4alkyl substituted with R13, C1-4alkyl substituted with —C(═O)—R13, C1-4alkoxy substituted with R13, C1-4alkoxy substituted with —C(═O)—R13, —C(═O)—R13, C1-4alkyl substituted with —NR7R8, C1-4alkyl substituted with —C(═O)—NR7R8, C1-4alkoxy substituted with —NR7R8, C1-4alkoxy substituted with —C(═O)—NR7R8, —NR7R8 and —C(═O)—NR7R8; or when two R2 groups are attached to adjacent carbon atoms they are optionally taken together to form a radical of formula: —O—(C(R17)2)p—O—; —X—CH═CH—; or —X—CH═N—; wherein R17 is hydrogen or fluorine, p is 1 or 2 and X is O or S; R3 is hydroxyl, C1-6alkoxy, hydroxyC1-6alkoxy, C1-6alkoxy substituted with —NR11R11, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, haloC1-6alkyl optionally substituted with —O—C(═O)—C1-6alkyl, hydroxyC1-6alkyl optionally substituted with —O—C(═O)—C1-6alkyl, hydroxyC2-6alkenyl, hydroxyC2-6alkynyl, hydroxyhaloC1-6alkyl, cyanoC1-6alkyl, C1-6alkyl substituted with carboxyl, C1-6alkyl substituted with —C(═O)—C1-6alkyl, C1-6alkyl substituted with —C(═O)—O—C1-6alkyl, C1-6alkyl substituted with C1-6alkoxyC1-6alkyl-O—C(═O)—, C1-6alkyl substituted with C1-6alkoxyC1-6alkyl-C(═O)—, C1-6alkyl substituted with —O—C(═O)—C1-6alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups or with —O—C(═O)—C1-6alkyl, C2-6alkenyl substituted with C1-6alkoxy, C2-6alkynyl substituted with C1-6alkoxy, C1-6alkyl substituted with R9 and optionally substituted with —O—C(═O)—C1-6alkyl, C1-6alkyl substituted with —C(═O)—R9, C1-6alkyl substituted with hydroxyl and R9, C2-6alkenyl substituted with R9, C2-6alkynyl substituted with R9, C1-6alkyl substituted with —NR10R11, C2-6alkenyl substituted with —NR10R11, C2-6alkynyl substituted with —NR10R11, C1-6alkyl substituted with hydroxyl and —NR10R11, C1-6alkyl substituted with one or two halogens and —NR10R11, —C1-6alkyl-C(R12)═N—O—R12, C1-6alkyl substituted with —C(═O)—NR10R11, C1-6alkyl substituted with —O—C(═O)—NR10R11, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NR12—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —NR12—S(═O)2—NR14R15, R13, C1-6alkyl substituted with —P(═O)(OH)2 or C1-6alkyl substituted with —P(═O)(OC1-6alkyl)2; R4 and R5 are each independently hydrogen, C1-6alkyl, hydroxyC1-6alkyl, haloC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2—NR14R15, R13 or C1-6alkyl substituted with R13; R6 is C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, 4 to 7-membered monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S; said C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, 4 to 7-membered monocyclic heterocyclyl, each optionally and each independently substituted by 1, 2, 3, 4 or 5 substituents, each substituent independently selected from cyano, C1-6alkyl, cyanoC1-6alkyl, hydroxyl, carboxyl, hydroxyC1-6alkyl, halogen, haloC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6alkyl-O—C(═O)—, —NR14R15, —C(═O)—NR14R15, C1-6alkyl substituted with —NR14R15, C1-6alkyl substituted with —C(═O)—NR14R15, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl and C1-6alkyl substituted with —NH—S(═O)2—NR14R15; R7 and R8 are each independently hydrogen, C1-6alkyl, hydroxyC1-6alkyl, haloC1-6alkyl, hydroxyhaloC1-6alkyl or C1-6alkoxyC1-6alkyl; R9 is C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, naphthyl, or 3 to 12 membered monocyclic or bicyclic heterocyclyl containing at least one heteroatom selected from N, O and S, said C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, naphthyl, or 3 to 12 membered monocyclic or bicyclic heterocyclyl each optionally and each independently substituted with 1, 2, 3, 4 or 5 substituents, each substituent independently selected from ═O, C1-4alkyl, hydroxyl, carboxyl, hydroxyC1-4alkyl, cyano, cyanoC1-4alkyl, C1-4alkyl-O—C(═O)—, C1-4alkyl substituted with C1-4alkyl-O—C(═O)—, C1-4alkyl-C(═O)—, C1-4alkoxyC1-4alkyl wherein each C1-4alkyl is optionally substituted with one or two hydroxyl groups, halogen, haloC1-4alkyl, hydroxyhaloC1-4alkyl, —NR14R15, —C(═O)—NR14R15, C1-4alkyl substituted with —NR14R15, C1-4alkyl substituted with —C(═O)—NR14R15, C1-4alkoxy, —S(═O)2—C1-4alkyl, —S(═O)2-haloC1-4alkyl, —S(═O)2—NR14R15, C1-4alkyl substituted with —S(═O)2—NR14R15, C1-4alkyl substituted with —NH—S(═O)2—C1-4alkyl, C1-4alkyl substituted with —NH—S(═O)2-haloC1-4alkyl, C1-4alkyl substituted with —NH—S(═O)2—NR14R15, R13, —C(═O)—R13, C1-4alkyl substituted with R13, phenyl optionally substituted with R16, phenylC1-6alkyl wherein the phenyl is optionally substituted with R16, and a 5 or 6-membered aromatic monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S wherein said heterocyclyl is optionally substituted with R16; or when two of the substituents of R9 are attached to the same atom, they are optionally taken together to form a 4 to 7-membered saturated monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S; R10 and R11 are each independently hydrogen, carboxyl, C1-6alkyl, cyanoC1-6alkyl, C1-6alkyl substituted with —NR14R15, C1-6alkyl substituted with —C(═O)—NR14R15, haloC1-6alkyl, hydroxyC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, R6, C1-6alkyl substituted with R6, —C(═O)—R6, —C(═O)—C1-6alkyl, —C(═O)-hydroxyC1-6alkyl, —C(═O)-haloC1-6alkyl, —C(═O)-hydroxyhaloC1-6alkyl, C1-6alkyl substituted with —Si(CH3)3, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl or C1-6alkyl substituted with —NH—S(═O)2—NR14R14R15; R12 is hydrogen or C1-4alkyl optionally substituted with C1-4alkoxy; R13 is C3-8cycloalkyl or a saturated 4 to 6-membered monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S, wherein said C3-8cycloalkyl or monocyclic heterocyclyl is optionally substituted with 1, 2 or 3 substituents each independently selected from halogen, hydroxyl, C1-6alkyl, —C(═O)—C1-6alkyl, C1-6alkoxy, and —NR14R15; R14 and R15 are each independently hydrogen, or haloC1-4alkyl, or C1-4alkyl optionally substituted with a substituent selected from hydroxyl, C1-4alkoxy, amino and mono- or di(C1-4alkyl)amino; and R16 is hydroxyl, halogen, cyano, C1-4alkyl, C1-4alkoxy, —NR14R15 or —C(═O)NR14R15; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 19. A method according to claim 18, wherein the cancer is selected from multiple myeloma, myeloproliferative disorders, endometrial cancer, prostate cancer, bladder cancer, lung cancer, ovarian cancer, breast cancer, gastric cancer, colorectal cancer, and oral squamous cell carcinoma. 20. A method according to claim 18, wherein the cancer is selected from lung cancer, squamous cell carcinoma, liver cancer, kidney cancer, breast cancer, colon cancer, colorectal cancer, and prostate cancer. 21. A method according to claim 19, wherein the cancer is multiple myeloma. 22. A method according to claim 21, wherein the cancer is t(4;14) translocation positive multiple myeloma. 23. A method according to claim 19, wherein the cancer is bladder cancer. 24. A method according to claim 23, wherein the cancer is bladder cancer with a FGFR3 chromosomal translocation. 25. A method according to claim 23, wherein the cancer is bladder cancer with a FGFR3 point mutation. 26. A method according to claim 18, wherein the cancer is a tumor with a mutant of FGFR1, FGFR2, FGFR3 or FGFR4. 27. A method according to claim 18, wherein the cancer is a tumor with a gain-of-function mutant of FGFR2 or FGFR3. 28. A method according to claim 18, wherein the cancer is a tumor with over-expression of FGFR1. 29. A method according to claim 18, wherein the cancer is urothelial carcinoma. 30. A method according to claim 18, wherein the compound is N-(3,5-dimethoxyphenyl)-N′-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 31. A method according to claim 30, wherein the compound is N-(3,5-dimethoxyphenyl)-N′-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine. 32. A method according to claim 18, wherein the compound is selected from: N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]-N′-(2,2,2-trifluoroethyl)propane-1,3-diamine; and N-(3,5-dimethoxyphenyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 33. A method for treating a subject suffering from a carcinoma, wherein the carcinoma is selected from a carcinoma of the bladder, breast, colon, kidney, epidermis, liver, lung, oesophagus, head and neck, gall bladder, ovary, pancreas, stomach, gastrointestinal (also known as gastric) cancer, cervix, endometrium, thyroid, prostate, or skin, a hematopoietic tumour of lymphoid lineage; a hematopoietic tumour of myeloid lineage; multiple myeloma; thyroid follicular cancer; a tumour of mesenchymal origin; a tumour of the central or peripheral nervous system; melanoma; seminoma; teratocarcinoma; osteosarcoma; xeroderma pigmentosum; keratoctanthoma; or Kaposi's sarcoma, said method comprising administering to the subject a compound selected from the group consisting of a compound of formula (I) a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein n is an integer equal to 0, 1, 2, 3 or 4; R1 is hydrogen, C1-6alkyl, C2-4alkenyl, hydroxyC1-6alkyl, haloC1-6alkyl, hydroxyhaloC1-6alkyl, cyanoC1-4alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, C1-6alkyl substituted with —NR4R5, C1-6alkyl substituted with —C(═O)—NR4R5, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —NR12—S(═O)2—NR14R15, R6, C1-6alkyl substituted with R6, C1-6alkyl substituted with —C(═O)—R6, hydroxyC1-6alkyl substituted with R6, C1-6alkyl substituted with —Si(CH3)3, C1-6alkyl substituted with —P(═O)(OH)2 or C1-6alkyl substituted with —P(═O)(OC1-6alkyl)2; each R1a is independently selected from hydrogen, C1-4alkyl, hydroxyC1-4alkyl, C1-4alkyl substituted with amino or mono- or di(C1-4alkyl)amino or —NH(C3-8cycloalkyl), cyanoC1-4alkyl, C1-4alkoxyC1-4alkyl, and C1-4alkyl substituted with one or more fluoro atoms; each R2 is independently selected from hydroxyl, halogen, cyano, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy, hydroxyC1-4alkyl, hydroxyC1-4alkoxy, haloC1-4alkyl, haloC1-4alkoxy, hydroxyhaloC1-4alkyl, hydroxyhaloC1-4alkoxy, C1-4alkoxyC1-4alkyl, haloC1-4alkoxyC1-4alkyl, C1-4alkoxyC1-4alkyl wherein each C1-4alkyl is optionally substituted with one or two hydroxyl groups, hydroxyhaloC1-4alkoxyC1-4alkyl, R13, C1-4alkyl substituted with R13, C1-4alkyl substituted with —C(═O)—R13, C1-4alkoxy substituted with R13, C1-4alkoxy substituted with —C(═O)—R13, —C(═O)—R13, C1-4alkyl substituted with —NR7R8, C1-4alkyl substituted with —C(═O)—NR7R8, C1-4alkoxy substituted with —NR7R8, C1-4alkoxy substituted with —C(═O)—NR7R8, —NR7R8 and —C(═O)—NR7R8; or when two R2 groups are attached to adjacent carbon atoms they are optionally taken together to form a radical of formula: —O—(C(R17)2)p—O—; —X—CH═CH—; or —X—CH═N—; wherein R17 is hydrogen or fluorine, p is 1 or 2 and X is O or S; R3 is hydroxyl, C1-6alkoxy, hydroxyC1-6alkoxy, C1-6alkoxy substituted with —NR11R11, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, haloC1-6alkyl optionally substituted with —O—C(═O)—C1-6alkyl, hydroxyC1-6alkyl optionally substituted with —O—C(═O)—C1-6alkyl, hydroxyC2-6alkenyl, hydroxyC2-6alkynyl, hydroxyhaloC1-6alkyl, cyanoC1-6alkyl, C1-6alkyl substituted with carboxyl, C1-6alkyl substituted with —C(═O)—C1-6alkyl, C1-6alkyl substituted with —C(═O)—O—C1-6alkyl, C1-6alkyl substituted with C1-6alkoxyC1-6alkyl-O—C(═O)—, C1-6alkyl substituted with C1-6alkoxyC1-6alkyl-C(═O)—, C1-6alkyl substituted with —O—C(═O)—C1-6alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups or with —O—C(═O)—C1-6alkyl, C2-6alkenyl substituted with C1-6alkoxy, C2-6alkynyl substituted with C1-6alkoxy, C1-6alkyl substituted with R9 and optionally substituted with —O—C(═O)—C1-6alkyl, C1-6alkyl substituted with —C(═O)—R9, C1-6alkyl substituted with hydroxyl and R9, C2-6alkenyl substituted with R9, C2-6alkynyl substituted with R9, C1-6alkyl substituted with —NR10R11, C2-6alkenyl substituted with —NR10R11, C2-6alkynyl substituted with —NR10R11, C1-6alkyl substituted with hydroxyl and —NR10R11, C1-6alkyl substituted with one or two halogens and —NR10R11, —C1-6alkyl-C(R12)═N—O—R12, C1-6alkyl substituted with —C(═O)—NR10R11, C1-6alkyl substituted with —O—C(═O)—NR10R11, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NR12—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —NR12—S(═O)2—NR14R15, R13, C1-6alkyl substituted with —P(═O)(OH)2 or C1-6alkyl substituted with —P(═O)(OC1-6alkyl)2; R4 and R5 are each independently hydrogen, C1-6alkyl, hydroxyC1-6alkyl, haloC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2—NR14R15, R13 or C1-6alkyl substituted with R13; R6 is C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, 4 to 7-membered monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S; said C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, 4 to 7-membered monocyclic heterocyclyl, each optionally and each independently substituted by 1, 2, 3, 4 or 5 substituents, each substituent independently selected from cyano, C1-6alkyl, cyanoC1-6alkyl, hydroxyl, carboxyl, hydroxyC1-6alkyl, halogen, haloC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6alkyl-O—C(═O)—, —NR14R15, —C(═O)—NR14R15, C1-6alkyl substituted with —NR14R15, C1-6alkyl substituted with —C(═O)—NR14R15, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl and C1-6alkyl substituted with —NH—S(═O)2—NR14R15; R7 and R8 are each independently hydrogen, C1-6alkyl, hydroxyC1-6alkyl, haloC1-6alkyl, hydroxyhaloC1-6alkyl or C1-6alkoxyC1-6alkyl; R9 is C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, naphthyl, or 3 to 12 membered monocyclic or bicyclic heterocyclyl containing at least one heteroatom selected from N, O and S, said C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, naphthyl, or 3 to 12 membered monocyclic or bicyclic heterocyclyl each optionally and each independently substituted with 1, 2, 3, 4 or 5 substituents, each substituent independently selected from ═O, C1-4alkyl, hydroxyl, carboxyl, hydroxyC1-4alkyl, cyano, cyanoC1-4alkyl, C1-4alkyl-O—C(═O)—, C1-4alkyl substituted with C1-4alkyl-O—C(═O)—, C1-4alkyl-C(═O)—, C1-4alkoxyC1-4alkyl wherein each C1-4alkyl is optionally substituted with one or two hydroxyl groups, halogen, haloC1-4alkyl, hydroxyhaloC1-4alkyl, —NR14R15, —C(═O)—NR14R15, C1-4alkyl substituted with —NR14R15, C1-4alkyl substituted with —C(═O)—NR14R15, C1-4alkoxy, —S(═O)2—C1-4alkyl, —S(═O)2-haloC1-4alkyl, —S(═O)2—NR14R15, C1-4alkyl substituted with —S(═O)2—NR14R15, C1-4alkyl substituted with —NH—S(═O)2—C1-4alkyl, C1-4alkyl substituted with —NH—S(═O)2-haloC1-4alkyl, C1-4alkyl substituted with —NH—S(═O)2—NR14R15, R13, —C(═O)—R13, C1-4alkyl substituted with R13, phenyl optionally substituted with R16, phenylC1-6alkyl wherein the phenyl is optionally substituted with R16, and a 5 or 6-membered aromatic monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S wherein said heterocyclyl is optionally substituted with R16; or when two of the substituents of R9 are attached to the same atom, they are optionally taken together to form a 4 to 7-membered saturated monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S; R10 and R11 are each independently hydrogen, carboxyl, C1-6alkyl, cyanoC1-6alkyl, C1-6alkyl substituted with —NR14R15, C1-6alkyl substituted with —C(═O)—NR14R15, haloC1-6alkyl, hydroxyC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, R6, C1-6alkyl substituted with R6, —C(═O)—R6, —C(═O)—C1-6alkyl, —C(═O)-hydroxyC1-6alkyl, —C(═O)-haloC1-6alkyl, —C(═O)-hydroxyhaloC1-6alkyl, C1-6alkyl substituted with —Si(CH3)3, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl or C1-6alkyl substituted with —NH—S(═O)2—NR14R14R15; R12 is hydrogen or C1-4alkyl optionally substituted with C1-4alkoxy; R13 is C3-8cycloalkyl or a saturated 4 to 6-membered monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S, wherein said C3-8cycloalkyl or monocyclic heterocyclyl is optionally substituted with 1, 2 or 3 substituents each independently selected from halogen, hydroxyl, C1-6alkyl, —C(═O)—C1-6alkyl, C1-6alkoxy, and —NR14R15; R14 and R15 are each independently hydrogen, or haloC1-4alkyl, or C1-4alkyl optionally substituted with a substituent selected from hydroxyl, C1-4alkoxy, amino and mono- or di(C1-4alkyl)amino; and R16 is hydroxyl, halogen, cyano, C1-4alkyl, C1-4alkoxy, —NR14R15 or —C(═O)NR14R15; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 34. A method according to claim 33, wherein the carcinoma is glioblastoma multiforme. 35. A method according to claim 33, wherein the compound is N-(3,5-dimethoxyphenyl)-N′-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 36. A method according to claim 35, wherein the compound is N-(3,5-dimethoxyphenyl)-N′-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine. 37. A method of inhibiting a FGFR kinase, which method comprises contacting the kinase with a kinase-inhibiting compound selected from the group consisting of a compound of formula (I) a tautomeric form, stereochemically isomeric form and isotopic form thereof, wherein n is an integer equal to 0, 1, 2, 3 or 4; R1 is hydrogen, C1-6alkyl, C2-4alkenyl, hydroxyC1-6alkyl, haloC1-6alkyl, hydroxyhaloC1-6alkyl, cyanoC1-4alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, C1-6alkyl substituted with —NR4R5, C1-6alkyl substituted with —C(═O)—NR4R5, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —NR12—S(═O)2—NR14R15, R6, C1-6alkyl substituted with R6, C1-6alkyl substituted with —C(═O)—R6, hydroxyC1-6alkyl substituted with R6, C1-6alkyl substituted with —Si(CH3)3, C1-6alkyl substituted with —P(═O)(OH)2 or C1-6alkyl substituted with —P(═O)(OC1-6alkyl)2; each R1a is independently selected from hydrogen, C1-4alkyl, hydroxyC1-4alkyl, C1-4alkyl substituted with amino or mono- or di(C1-4alkyl)amino or —NH(C3-8cycloalkyl), cyanoC1-4alkyl, C1-4alkoxyC1-4alkyl, and C1-4alkyl substituted with one or more fluoro atoms; each R2 is independently selected from hydroxyl, halogen, cyano, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy, hydroxyC1-4alkyl, hydroxyC1-4alkoxy, haloC1-4alkyl, haloC1-4alkoxy, hydroxyhaloC1-4alkyl, hydroxyhaloC1-4alkoxy, C1-4alkoxyC1-4alkyl, haloC1-4alkoxyC1-4alkyl, C1-4alkoxyC1-4alkyl wherein each C1-4alkyl is optionally substituted with one or two hydroxyl groups, hydroxyhaloC1-4alkoxyC1-4alkyl, R13, C1-4alkyl substituted with R13, C1-4alkyl substituted with —C(═O)—R13, C1-4alkoxy substituted with R13, C1-4alkoxy substituted with —C(═O)—R13, —C(═O)—R13, C1-4alkyl substituted with —NR7R8, C1-4alkyl substituted with —C(═O)—NR7R8, C1-4alkoxy substituted with —NR7R8, C1-4alkoxy substituted with —C(═O)—NR7R8, —NR7R8 and —C(═O)—NR7R8; or when two R2 groups are attached to adjacent carbon atoms they are optionally taken together to form a radical of formula: —O—(C(R17)2)p—O—; —X—CH═CH—; or —X—CH═N—; wherein R17 is hydrogen or fluorine, p is 1 or 2 and X is O or S; R3 is hydroxyl, C1-6alkoxy, hydroxyC1-6alkoxy, C1-6alkoxy substituted with —NR10R11, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, haloC1-6alkyl optionally substituted with —O—C(═O)—C1-6alkyl, hydroxyC1-6alkyl optionally substituted with —O—C(═O)—C1-6alkyl, hydroxyC2-6alkenyl, hydroxyC2-6alkynyl, hydroxyhaloC1-6alkyl, cyanoC1-6alkyl, C1-6alkyl substituted with carboxyl, C1-6alkyl substituted with —C(═O)—C1-6alkyl, C1-6alkyl substituted with —C(═O)—O—C1-6alkyl, C1-6alkyl substituted with C1-6alkoxyC1-6alkyl-O—C(═O)—, C1-6alkyl substituted with C1-6alkoxyC1-6alkyl-C(═O)—, C1-6alkyl substituted with —O—C(═O)—C1-6alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups or with —O—C(═O)—C1-6alkyl, C2-6alkenyl substituted with C1-6alkoxy, C2-6alkynyl substituted with C1-6alkoxy, C1-6alkyl substituted with R9 and optionally substituted with —O—C(═O)—C1-6alkyl, C1-6alkyl substituted with —C(═O)—R9, C1-6alkyl substituted with hydroxyl and R9, C2-6alkenyl substituted with R9, C2-6alkynyl substituted with R9, C1-6alkyl substituted with —NR10R11, C2-6alkenyl substituted with —NR10R11, C2-6alkynyl substituted with —NR10R11, C1-6alkyl substituted with hydroxyl and —NR10R11, C1-6alkyl substituted with one or two halogens and —NR10R11, C1-6alkyl-C(R12)═N—O—R12, C1-6alkyl substituted with —C(═O)—NR10R11, C1-6alkyl substituted with —O—C(═O)—NR10R11, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NR12—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —NR12—S(═O)2—NR14R15, R13, C1-6alkyl substituted with —P(═O)(OH)2 or C1-6alkyl substituted with —P(═O)(OC1-6alkyl)2; R4 and R5 are each independently hydrogen, C1-6alkyl, hydroxyC1-6alkyl, haloC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2—NR14R15, R13 or C1-6alkyl substituted with R13; R6 is C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, 4 to 7-membered monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S; said C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, 4 to 7-membered monocyclic heterocyclyl, each optionally and each independently substituted by 1, 2, 3, 4 or 5 substituents, each substituent independently selected from cyano, C1-6alkyl, cyanoC1-6alkyl, hydroxyl, carboxyl, hydroxyC1-6alkyl, halogen, haloC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6alkyl-O—C(═O)—, —NR14R15, —C(═O)—NR14R15, C1-6alkyl substituted with —NR14R15, C1-6alkyl substituted with —C(═O)—NR14R15, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl and C1-6alkyl substituted with —NH—S(═O)2—NR14R15; R7 and R8 are each independently hydrogen, C1-6alkyl, hydroxyC1-6alkyl, haloC1-6alkyl, hydroxyhaloC1-6alkyl or C1-6alkoxyC1-6alkyl; R9 is C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, naphthyl, or 3 to 12 membered monocyclic or bicyclic heterocyclyl containing at least one heteroatom selected from N, O and S, said C3-8cycloalkyl, C3-8cycloalkenyl, phenyl, naphthyl, or 3 to 12 membered monocyclic or bicyclic heterocyclyl each optionally and each independently substituted with 1, 2, 3, 4 or 5 substituents, each substituent independently selected from ═O, C1-4alkyl, hydroxyl, carboxyl, hydroxyC1-4alkyl, cyano, cyanoC1-4alkyl, C1-4alkyl-O—C(═O)—, C1-4alkyl substituted with C1-4alkyl-O—C(═O)—, C1-4alkyl-C(═O)—, C1-4alkoxyC1-4alkyl wherein each C1-4alkyl is optionally substituted with one or two hydroxyl groups, halogen, haloC1-4alkyl, hydroxyhaloC1-4alkyl, —NR14R15, —C(═O)—NR14R15, C1-4alkyl substituted with —NR14R15, C1-4alkyl substituted with —C(═O)—NR14R15, C1-4alkoxy, —S(═O)2—C1-4alkyl, —S(═O)2-haloC1-4alkyl, —S(═O)2—NR14R15, C1-4alkyl substituted with —S(═O)2—NR14R15, C1-4alkyl substituted with —NH—S(═O)2—C1-4alkyl, C1-4alkyl substituted with —NH—S(═O)2-haloC1-4alkyl, C1-4alkyl substituted with —NH—S(═O)2—NR14R15, R13, —C(═O)—R13, C1-4alkyl substituted with R13, phenyl optionally substituted with R16, phenylC1-6alkyl wherein the phenyl is optionally substituted with R16, and a 5 or 6-membered aromatic monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S wherein said heterocyclyl is optionally substituted with R16; or when two of the substituents of R9 are attached to the same atom, they are optionally taken together to form a 4 to 7-membered saturated monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S; R10 and R11 are each independently hydrogen, carboxyl, C1-6alkyl, cyanoC1-6alkyl, C1-6alkyl substituted with —NR14R15, C1-6alkyl substituted with —C(═O)—NR14R15, haloC1-6alkyl, hydroxyC1-6alkyl, hydroxyhaloC1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl wherein each C1-6alkyl is optionally substituted with one or two hydroxyl groups, R6, C1-6alkyl substituted with R6, —C(═O)—R6, —C(═O)—C1-6alkyl, —C(═O)-hydroxyC1-6alkyl, —C(═O)-haloC1-6alkyl, —C(═O)-hydroxyhaloC1-6alkyl, C1-6alkyl substituted with —Si(CH3)3, —S(═O)2—C1-6alkyl, —S(═O)2-haloC1-6alkyl, —S(═O)2—NR14R15, C1-6alkyl substituted with —S(═O)2—C1-6alkyl, C1-6alkyl substituted with —S(═O)2-haloC1-6alkyl, C1-6alkyl substituted with —S(═O)2—NR14R15, C1-6alkyl substituted with —NH—S(═O)2—C1-6alkyl, C1-6alkyl substituted with —NH—S(═O)2-haloC1-6alkyl or C1-6alkyl substituted with —NH—S(═O)2—NR14R14R15; R12 is hydrogen or C1-4alkyl optionally substituted with C1-4alkoxy; R13 is C3-8cycloalkyl or a saturated 4 to 6-membered monocyclic heterocyclyl containing at least one heteroatom selected from N, O and S, wherein said C3-8cycloalkyl or monocyclic heterocyclyl is optionally substituted with 1, 2 or 3 substituents each independently selected from halogen, hydroxyl, C1-6alkyl, —C(═O)—C1-6alkyl, C1-6alkoxy, and —NR14R15; R14 and R15 are each independently hydrogen, or haloC1-4alkyl, or C1-4alkyl optionally substituted with a substituent selected from hydroxyl, C1-4alkoxy, amino and mono- or di(C1-4alkyl)amino; and R16 is hydroxyl, halogen, cyano, C1-4alkyl, C1-4alkoxy, —NR14R15 or —C(═O)NR14R15; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 38. A method according to claim 37, wherein the compound is N-(3,5-dimethoxyphenyl)-N′-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 39. A method according to claim 38, wherein the compound is N-(3,5-dimethoxyphenyl)-N′-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine. 40. A method according to claim 1, further comprising administering to the subject one or more other anticancer agents. 41. A method according to claim 40, wherein the one or more other anticancer agents comprises a kinase inhibitor. 42. A method according to claim 40, wherein the compound is N-(3,5-dimethoxyphenyl)-N′-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine; or an N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. 43. A method according to claim 42, wherein the compound is N-(3,5-dimethoxyphenyl)-N′-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine. 44. A method according to claim 20 wherein the lung cancer is NSCLC. 45. A method according to claim 33 wherein the carcinoma is adenocarcinoma of the lung, small cell lung cancer or non-small cell lung carcinoma.