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Summary for Patent: 9,447,077
|Title:||Crystalline pharmaceutical and methods of preparation and use thereof|
|Abstract:||Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this invention. ##STR00001##|
|Inventor(s):||Burnier; John (Pacifica, CA), Gadek; Thomas (Oakland, CA), Naud; Frederic (Binningen, CH)|
|Assignee:||SARcode Bioscience Inc. (Brisbane, CA)|
1. A method of treating dry eye disease in a subject in need of such treatment, the method comprising administering to the subject an effective amount of a composition
comprising an isolated compound of Formula I: ##STR00028## or a pharmaceutically acceptable salt thereof, wherein said compound comprises a purity of greater than about 90%.
2. The method of claim 1, wherein said compound has a purity of greater than about 98%.
3. The method of claim 1, wherein said compound comprises at least about 95% of an S-enantiomer.
4. The composition of claim 1, wherein said compound is a sodium salt.
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