Claims for Patent: 9,440,922

Summary for Patent: 9,440,922

Title:	Tetracyclic compound
Abstract:	A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: (meanings of the symbols that are included in the formula are as given in the specification).
Inventor(s):	Kazutomo Kinoshita, Kohsuke Asoh, Noriyuki Furuichi, Toshiya Ito, Hatsuo Kawada, Nobuya Ishii, Hiroshi Sakamoto, WooSang Hong, MinJeong Park, Yoshiyuki Ono, Yasuharu Kato, Kenji Morikami, Takashi Emura, Nobuhiro Oikawa
Assignee:	Chugai Pharmaceutical Co Ltd
Application Number:	US14/619,242
Patent Claims:	1. A pharmaceutical for the treatment of cancer, cancer metastasis, or depression, comprising one or more pharmaceutically acceptable carriers and as an active ingredient a compound represented by Formula (I): wherein, A5 is selected from NR5, O and S; A4, A7, and A9 represent CR4, CR7, and CR9 respectively, or wherein A4 is N and A7 and A9 represent CR7 and CR9 respectively; R1 and R10 each independently represent [1] a hydrogen atom, [2] a cyano group, [3] a halogen atom or [4] a 4- to 10-membered heterocycloalkyl group which may be substituted by 4- to 10-membered heterocycloalkyl group(s); R2 is selected from the group consisting of: (1) a hydrogen atom, (2) a C1-8 alkyl group, (3) a C2-8 alkenyl group, (4) a C2-8 alkynyl group, (5) a cyano group, (6) a halogen atom, (7) a (C1-8 alkyl)m2-amino group which may be substituted by C1-8 alkylsulfonyl group(s), m2: 0˜2, and (8) a nitro group; R3 is selected from the group consisting of: (1) a hydrogen atom, (2) a C1-8 alkyl group which may be substituted by [1] halogen atom(s), [2] hydroxy group(s) or [3] C1-8 alkoxy group(s), (3) a C6-10 aryl group, (4) a cyano group, (5) a C1-8 alkanoyl group which may be substituted by C6-10 aryl group(s), I. (6) a (C1-8 alkyl)m3a-aminocarbonyl group which may be substituted by one or more R3A, II. R3A: [1] a C6-10 aryl group, [2] a C1-8 alkoxy group, [3] a 5- to 14-membered heteroaryl group, or [4] a C6-10 arylsulfonyl group, III. m3a: 0˜2, (7) a hydroxycarbonyl group, (8) a C1-8 alkoxycarbonyl group which may be substituted by [1] hydroxy group(s) or [2] C1-8 alkoxy group(s), (9) a halogen atom, (10) a (C1-8 alkyl)m3b-amino group which may be substituted by C6-10 aryl group(s), m3b: 0˜2, (11) a C1-8 alkylcarbonyl (C0-8 alkyl) amino group which may be substituted by [1] C6-10 aryl group(s) or [2] C6-10 aryloxy group(s), (12) a C6-10 arylcarbonyl (C0-8 alkyl) amino group which may be substituted by C1-8 alkyl group(s) which may be substituted by halogen atom(s), (13) a (C1-8 alkyl)m3c-aminocarbonyl (C0-8 alkyl) amino group which may be substituted by C6-10 aryl group(s), m3c: 0˜2, (14) a nitro group, (15) a hydroxy group, (16) a C1-8 alkoxy group which may be substituted by one or more R3B, R3B: [1] a hydroxy group, [2] a C1-8 alkoxy group, [3] a C6-10 aryl (C0-8 alkyl) aminocarbonyl group, [4] a (C1-8 alkyl)m3d-amino group, or [5] a halogen atom, m3d: 0˜2, (17) a 4- to 10-membered heterocycloalkyloxy group, (18) a 5- to 14-membered heteroaryloxy group, (19) a (C1-8 alkyl)m3e-aminocarbonyloxy group which may be substituted by C6-10 aryl group(s) m3e: 0˜2, (20) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group, (21) a C1-8 alkylsulfonyloxy group which may be substituted by halogen atom(s), (22) a C1-8 alkylthio group, (23) a C1-8 alkylsulfonyl group which may be substituted by C6-10 aryl group(s), (24) a 5- to 14-membered heteroaryl group which may be substituted by C1-8 alkyl group(s) which may be substituted by C1-8 alkoxy group(s), (25) a C1-8 alkoxycarbonyl (C0-8 alkyl) amino group which may be substituted by C1-8 alkoxy group(s), (26) a C6-10 aryloxycarbonyl (C0-8 alkyl) amino group which may be substituted by C1-8 alkyl group(s) which may be substituted by halogen atom(s), (27) a C6-10 aryl (C0-8 alkyl) aminocarbonyl (C0-8 alkyl) amino group which may be substituted by one or more R3C, R3C: [1] a C1-8 alkyl group which may be substituted by halogen atom(s), or [2] a C1-8 alkoxy group, (28) a C3-8 cycloalkyl (C0-8 alkyl) aminocarbonyloxy group, and (29) a C6-10 aryl (C0-8 alkyl) aminocarbonyloxy group which may be substituted by substituent(s) selected from the group consisting of [1] a C1-8 alkyl group and [2] a C1-8 alkoxy group; R4 is selected from the group consisting of: (1) a hydrogen atom, (2) a C1-8 alkyl group which may be substituted by halogen atom(s), (3) a C2-8 alkenyl group, (4) a C2-8 alkynyl group, (5) a C3-8 cycloalkyl group, (6) a cyano group, (7) an aminocarbonyl group, (8) a (C1-8 alkyl)m4a-aminocarbonyl group, m4a: 1˜2, (9) a hydroxycarbonyl group, (10) a C1-8 alkoxycarbonyl group, (11) a halogen atom, (12) a (C1-8 alkyl)m4b-amino group, m4b: 0˜2, (13) a hydroxy group, and (14) a C1-8 alkoxy group which may be substituted by hydroxy group(s); R5 is selected from the group consisting of: (1) a hydrogen atom, (2) a C1-8 alkyl group which may be substituted by one or more R5A, R5A: [1] a hydroxycarbonyl group, [2] a C1-8 alkoxycarbonyl group, [3] a hydroxy group, [4] a C1-8 alkoxy group, [5] a (C1-8 alkyl)m5-amino group, [6] a C6-10 aryl group, or [7] a C1-8 alkylthio group, m5: 0˜2, (3) a C2-8 alkenyl group, (4) a C2-8 alkynyl group, (5) a C3-8 cycloalkyl group, and (6) a C1-8 alkylsulfonyl group; R6 and R6′ are each independently selected from the group consisting of: (1) a C1-8 alkyl group which may be substituted by halogen atom(s), (2) a C2-8 alkenyl group, and (3) a C2-8 alkynyl group; or R6 and R6′ are taken together with the carbon atoms to which they are bound to form: (4) a C3-8 cycloalkyl group, or (5) a 4- to 10-membered heterocycloalkyl group which may be substituted by C1-8 alkyl C6-10 aryl sulfonyl group(s) which may be substituted by C1-8 alkyl group(s); R7 is selected from the group consisting of: (1) a hydrogen atom, (2) a halogen atom, IV. (3) a C1-8 alkoxy group which may be substituted by one or more R7A, V. R7A: [1] a (C1-8 alkyl)m7a-amino group, [2] a hydroxy, [3] a 4- to 10-membered heterocycloalkyl group which may be substituted by C1-8 alkyl group(s), VI. m7a: 0˜2, (4) a C1-8 alkylsulfonyl group, (5) a nitro group, and (6) a hydroxyl group; R8 is selected from the group consisting of: (1) a hydrogen atom, (2) a C1-8 alkyl group which may be substituted by one or more R8A, R8A: [1] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R8A1, [2] a (C1-8 alkyl)m8a-amino group which may be substituted by a halogen atom, or [3] a hydroxy group, m8a:0˜2, R8A1: [1] a C1-8 alkyl group, [2] a C1-8 alkylsulfonyl group, [3] a (C1-8 alkyl)m8b-aminosulfonyl group, [4] an oxo group, [5] a C1-8 alkoxycarbonyl, or [6] a C1-8 alkoxycarbonyl (C0-8 alkyl) aminosulfonyl, m8b: 0˜2, (3) a C2-8 alkenyl group, (4) a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R8B, R8B: <1> a C1-8 alkyl group which may be substituted by one or more R8B1, <2> a C2-8 alkeynyl group, <3> a C2-8 alkynyl group, <4> a C3-8 cycloalkyl group which may be substituted by [1] cyano group(s) or [2] C1-8 alkyl group(s), <5> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R8B2, <6> a C1-8 alkoxy group which may be substituted by substituent(s) selected from the group consisting of [1] a C1-8 alkoxy group and [2] a C3-8 cycloalkyl group, <7> a C1-8 alkoxycarbonyl group, <8> a C1-8 alkylsulfonyl group, <9> a 5- to 14-membered heteroarylsulfonyl group, <10> an oxo group, <11> a cyano group, <12> a C1-8 alkanoyl group which may be substituted by one or more R8B3, <13> a C3-8 cycloalkylcarbonyl group, <14> a (C1-8 alkyl)m8c-aminosulfonyl group, <15> a C1-8 alkylsulfonyl (C0-8 alkyl) amino group, <16> a (C1-8 alkyl)m8d-amino group which may be substituted by one or more R8B4, <17> a hydroxy group, <18> a (C1-8 alkyl)m8e-aminocarbonyl group, or <19> a C1-8 alkoxycarbonyl (C0-8 alkyl) amino group m8c: 0˜2 m8d: 0˜2 m8e: 0˜2 R8B1: [1] a C3-8 cycloalkyl group, [2] a hydroxy group, or [3] a C1-8 alkoxy group(s), R8B2: [1] a halogen atom, [2] a C1-8 alkyl group, [3] an oxo group, [4] a hydroxy group, or [5] a deuterium atom, R8B3: a (C1-8 alkyl)m8f-amino group, m8f: 0˜2, R8B4: [1] a C3-8 cycloalkyl group, or [2] a hydroxy group, (5) a 5- to 14-membered heteroaryl group which may be substituted by a C1-8 alkyl group, (6) a (C1-8 alkyl)m8g-aminocarbonyl group which may be substituted by one or more R8C, m8g: 0˜2, R8C: [1] a hydroxy group, [2] a (C1-8 alkyl)m8h-amino group which may be substituted by substituent(s) selected from the group consisting of <1> a (C1-8 alkyl)m8i-aminosulfonyl group, <2> a C1-8 alkylsulfonyl group, <3> a C1-8 alkoxycarbonyl group and <4> a C1-8 alkoxycarbonyl(C0-8 alkyl) aminosulfonyl group, [3] a C1-8 alkylsulfonyl group, or [4] a C1-8 alkoxy group which may be substituted by a hydroxy group, m8h: 0˜2, m8i: 0˜2, (7) a 4- to 10-membered heterocycloalkyl (C0-8 alkyl) aminocarbonyl group which may be substituted by oxo group(s), (8) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by one or more R8D, R8D: [1] a C1-8 alkyl group which may be substituted by one or more R8D1, [2] a hydroxy group, [3] a C1-8 alkylsulfonyl group, or [4] a C1-8 alkoxycarbonyl group, R8D1: [1] a hydroxy group, or [2] a C1-8 alkoxy group, (9) a hydroxycarbonyl group, (10) a C0-8 alkoxy (C0-8 alkyl) aminocarbonyl group which may be substituted by hydroxy group(s), (11) a halogen atom, (12) a (C1-8 alkyl)m8j-amino group which may be substituted by one or more R8H, m8j: 0˜2, R8H: [1] a hydroxy group, or [2] a 4- to 10-membered heterocycloalkyl group, (13) a hydroxyl group, (14) a C1-8 alkoxy group which may be substituted by one or more R8E, R8E: <1> a hydroxy group, <2> halogen atom, <3> a hydroxycarbonyl group, <4> a C1-8 alkoxycarbonyl group, <5> a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by one or more R8E1, <6> a (C1-8 alkyl)m8k1-amino group which may be substituted by one or more R8E2, m8k1: 0˜2, <7> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R8E3, <8> a 5- to 14-membered heteroaryl group, <9> a (C1-8 alkyl)m8k2-aminocarbonyl group which may be substituted by one or more R8E6, m8k2: 0˜2, <10> a C1-8 alkoxy group which may be substituted by one or more R8E7, <11> a C1-8 alkylthio group, <12> a C1-8 alkylsulfinyl group, <13> a C1-8 alkylsulfonyl group, R8E1: <1> a C1-8 alkoxycarbonyl group, <2> a C1-8 alkanoyl group, <3> a C1-8 alkylsulfonyl group, <4> a (C1-8 alkyl)m8k3-aminosulfonyl group, m8k3: 0˜2, or <5> a 4- to 10-membered heterocycloalkyl group, R8E2: <1> a hydroxy group, <2> a C1-8 alkoxycarbonyl group which may be substituted by halogen atom(s), <3> a C3-8 cycloalkyl group which may be substituted by C1-8 alkyl group(s) which may be substituted by hydroxy group(s), <4> a C1-8 alkanoyl group which may be substituted by substituent(s) selected from the group consisting of [1] a (C1-8 alkyl)m8k4-amino group and [2] a halogen atom(s), m8k4: 0˜2, <5> a (C1-8 alkyl)m8k5-aminocarbonyl group, m8k5: 0˜2, <6> a C1-8 alkylsulfonyl group, <7> a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyl group which may be substituted by C1-8 alkyl group(s), <8> a (C1-8 alkyl)m8k6-aminosulfonyl group which may be substituted by C1-8 alkoxycarbonyl group(s), m8k6: 0˜2, or R8E3: <1> a C1-8 alkyl group which may be substituted by substituent(s) selected from the group consisting of [1] a hydroxy group and [2] a C1-8 alkylcarbonyloxy group, <2> a C1-8 alkylcarbonyloxy group, <3> a hydroxy group, <4> a C3-8 cycloalkyl group, <5> a C1-8 alkoxy group, <6> a C1-8 alkoxycarbonyl group, <7> a C1-8 alkylsulfonyl group, <8> a (C1-8 alkyl)m8k8-aminocarbonyl group m8k8: 0˜2, <9> a C1-8 alkanoyl group which may be substituted by hydroxy group(s), <10> an oxo group, or <11> a 4- to 10-membered heterocycloalkyl group which may be substituted by substituent(s) selected from the group consisting of [1] a C1-8 alkanoyl group, [2] a C1-8 alkoxycarbonyl group and [3] a C1-8 alkylsulfonyl group, R8E6: <1> a C2-8 alkenylcarbonyloxy group, <2> a hydroxy group, <3> a cyano group, <4> a (C1-8 alkyl)m8k9-amino group which may be substituted by hydroxy group(s) m8k9: 0˜2, <5> a C1-8 alkoxy group which may be substituted by hydroxy group(s), <6> a C1-8 alkylcarbonyloxy group, <7> a 4- to 10-membered heterocycloalkyl group which may be substituted by C1-8 alkyl group(s), or <8> a 5- to 14-membered heteroaryl group, R8E7: <1> a hydroxy group, or <2> a C1-8 alkoxy group which may be substituted by hydroxy group(s), (15) a 4- to 10-membered heterocycloalkyloxy group which may be substituted by one or more R8F, R8F: <1> a C1-8 alkyl group which may be substituted by one or more R8F1, <2> a C3-8cycloalkyl group, <3> a C1-8 alkanoyl group which may be substituted by halogen atom(s), <4> a C1-8 alkylcarbonyloxy group, <5> a C1-8 alkoxycarbonyl group, <6> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R8F2, <7> a C1-8 alkyl sulfonyl group, <8> a hydroxy group, or [9] a C6-10 aryl group, R8F1: [1] a hydroxy group, [2] a C1-8 alkoxy group, or [3] a halogen atom, R8F2: [1] a 4- to 10-membered heterocycloalkyl group, [2] a C1-8 alkoxycarbonyl group, or [3] a C1-8 alkylsulfonyl group, (16) a 5- to 14-membered heteroaryloxy group, (17) a 4- to 10-membered heterocycloalkylcarbonyloxy group, (18) a (C1-8 alkyl)m8l1-aminosulfonyloxy group, m8l1: 0˜2, (19) a C1-8 alkyl thio group which may be substituted by [1] (C1-8 alkyl)m8l2-amino group(s), [2] hydroxy group(s) or [3] hydroxycarbonyl group(s), m8l2: 0˜2, (20) a C1-8 alkylsulfonyl group which may be substituted by one or more R8G, R8G: [1] a hydroxycarbonyl group, [2] a hydroxy group, or [3] a (C1-8 alkyl)m8l3-amino group, m8l3: 0˜2, (21) a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyloxy group which may be substituted by C1-8 alkyl group(s), (22) a C2-8 alkenyloxy group, and (23) a C1-8 alkylsulfonyloxy group which may be substituted by halogen atom(s); R9 is selected from the group consisting of: (1) a hydrogen atom, (2) a C1-8 alkyl group which may be substituted by one or more R9A, R9A: [1] a C3-8 cycloalkyl group, [2] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R9A1, [3] a hydroxy group, [4] a C1-8 alkoxy group, or [5] a hydroxycarbonyl group, R9A1: [1] a C1-8 alkyl group, [2] a C3-8 cycloalkyl group, or [3] a 4- to 10-membered heterocycloalkyl group, (3) a C2-8 alkenyl group which may be substituted by one or more R9B, R9B: [1] a (C1-8 alkyl)m9a-amino group, [2] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more group R9B1, R9B1: [1] a C3-8 cycloalkyl group, or [2] a 4- to 10-membered heterocycloalkyl group, m9a: 0˜2, (4) a C2-8 alkynyl group which may be substituted by one or more R9C, R9C: [1] a C1-8 alkoxy group, [2] a (C1-8 alkyl)m9b-amino group which may be substituted by C6-10 aryl group(s), [3] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R9C1, [4] a C3-8 cycloalkyl group, [5] a hydroxy group, [6] a hydroxycarbonyl group, or [7] a C1-8 alkyloxycarbonyl group, m9b: 0˜2, R9C1: [1] a C3-8 cycloalkyl group, [2] a 4- to 10-membered heterocycloalkyl group, or [3] an oxo group, (5) a C3-8 cycloalkyl group, (6) a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R9D, R9D: [1] a C1-8 alkyl group which may be substituted by 4- to 10-membered heterocycloalkyl group(s), [2] a C3-8 cycloalkyl group, [3] a 4- to 10-membered heterocycloalkyl group, or [4] a C1-6 alkylsulfonyl group, or [5] a C1-8 alkoxycarbonyl group, (7) a C6-10 aryl group which may be substituted by one or more R9E, R9E: [1] a halogen atom, [2] a hydroxy group, [3] a hydroxycarbonyl group, or [4] a C1-8 alkyl group which may be substituted by hydroxy group(s), or [5] a C1-8 alkoxy group, (8) a 5- to 14-membered heteroaryl group which may be substituted by C1-8 alkyl group(s), (9) a cyano group, (10) a C1-8 alkanoyl group, (11) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by C1-8 alkyl group(s), (12) a halogen atom, (13) a (C1-8 alkyl)m9c-amino group which may be substituted by one or more R9F, m9c: 0˜2, R9F: [9F-1] a C1-3 alkylsulfonyl group, [9F-2] a (C1-3 alkyl)m9f1-aminosulfonyl group (m9f1: 0˜2), or [9F-3] a C1-3 alkanoyl group which may be substituted by (C1-3 alkyl)m9f2-amino group(s) (m9f2: 0˜2), (14) a C1-8 alkylcarbonyl(C0-8 alkyl)amino group which may be substituted by (C1-8 alkyl)m9d-amino group(s), m9d: 0˜2, (15) a C1-8 alkylsulfonyl(C0-8 alkyl)amino group, (16) a (C1-8 alkyl)m9e-aminosulfonyl(C0-8 alkyl)amino group, m9e: 0˜2, (17) a nitro group, (18) a hydroxy group, (19) a C1-8 alkoxy group which may be substituted by one or more R9G, R9G: [1] a hydroxy group, [2] a hydroxycarbonyl group, [3] a C6-10 aryl group which may be substituted by C1-8 alkoxy group(s), [4] a (C1-8 alkyl)m9g1-amino group, [5] a C1-8 alkoxy group which may be substituted by one or more R9G1, [6] a 5- to 14-membered heteroaryl group, or [7] a 4- to 10-membered heterocycloalkyloxy group which may be substituted by C1-8 alkyl group(s), m9g1: 0˜2, R9G1: [1] a C1-8 alkoxy group, or [2] a hydroxycarbonyl group, (20) a 4- to 10-membered heterocycloalkyloxy group which may be substituted by [1] 4- to 10-membered heterocycloalkyl group(s), or [2] C1-8 alkoxycarbonyl group(s), (21) a C1-8 alkylsulfonyloxy group which may be substituted by halogen atom(s), (22) a C1-8 alkylthio group which may be substituted by (C1-8 alkyl)m9f-amino group(s), m9f: 0˜2, (23) a C1-8 alkylsulfonyl group which may be substituted by (C1-8 alkyl)m9g-amino group(s), m9g: 0˜2, (24) a (C1-8 alkyl)m9h-aminosulfonyl group, m9h: 0˜2, (25) a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyl group which may be substituted by C1-8 alkyl group(s), and (26) a hydroxycarbonyl group, or a salt or solvate thereof. 2. The pharmaceutical of claim 1, wherein R3 is a cyano group or a halogen atom. 3. The pharmaceutical of claim 1, wherein A5 is NR5 and R5 is a hydrogen atom. 4. The pharmaceutical of claim 1, wherein A5 is NR5 and R5 is a hydrogen atom. 5. The pharmaceutical of claim 1, wherein: A1, A2, A3, A4, A7, A8, A9 and A10 all represent C; A5 is selected from NR5, O and S; R1 represents [1] a hydrogen atom, [2] a cyano group, or [3] a halogen atom; R2 is selected from the group consisting of: (1) a hydrogen atom, (2) a C1-8 alkyl group, (3) a cyano group, (4) a halogen atom, and (5) a (C1-8 alkyl)m2-amino group which may be substituted by C1-8 alkylsulfonyl group(s), m2: 0˜2; R3 is selected from the group consisting of: (1) a hydrogen atom, (2) a C1-8 alkyl group which may be substituted by halogen atom(s), (3) a cyano group, VII. (4) a (C1-8 alkyl)m3a-aminocarbonyl group which may be substituted by one or more R3A, VIII. R3A: [1] a C6-10 aryl group, [2] a C1-8 alkoxy group, [3] a 5- to 14-membered heteroaryl group, or [4] a C6-10 aryl sulfonyl group, m3a: 0˜2, (5) a hydroxycarbonyl group, (6) a C1-8 alkoxycarbonyl group which may be substituted by hydroxy group(s), (7) a halogen atom, (8) a (C1-8 alkyl)m3b-amino group which may be substituted by C6-10 aryl group(s), m3b: 0˜2, (9) a C1-8 alkylcarbonyl (C0-8 alkyl) amino group which may be substituted by [1] C6-10 aryl group(s) or [2] C6-10 aryloxy group(s), (10) a C6-10 arylcarbonyl (C0-8 alkyl) amino group which may be substituted by C1-8 alkyl group(s) which may be substituted by halogen atom(s), (11) a nitro group, (12) a hydroxy group, (13) a C1-8 alkoxy group which may be substituted by one or more R3B, R3B: [1] a hydroxy group, [2] a C1-8 alkoxy group, [3] a C6-10 aryl (C0-8 alkyl) aminocarbonyl group, [4] a (C1-8 alkyl)m3d-amino group, or [5] a halogen atom, m3d: 0˜2, (14) a 4- to 10-membered heterocycloalkyloxy group, (15) a 5- to 14-membered heteroaryloxy group, (16) a (C1-8 alkyl)m3e-aminocarbonyloxy group which may be substituted by C6-10 aryl group(s), m3e: 0˜2, (17) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group, (18) a C1-8 alkylthio group, (19) a 5- to 14-membered heteroaryl group which may be substituted by C1-8 alkyl group(s) which may be substituted by C1-8 alkoxy group(s), (20) a C1-8 alkoxycarbonyl (C0-8 alkyl) amino group which may be substituted by C1-8 alkoxy group(s), (21) a C6-10 aryloxycarbonyl (C0-8 alkyl) amino group which may be substituted by C1-8 alkyl group(s) which may be substituted by halogen atom(s), (22) a C6-10 aryl (C0-8 alkyl) aminocarbonyl (C0-8 alkyl) amino group which may be substituted by C1-8 alkoxy group(s), (23) a C3-8 cycloalkyl (C0-8 alkyl) aminocarbonyloxy group, and (24) a C6-10 aryl (C0-8 alkyl) aminocarbonyloxy group which may be substituted by substituent(s) selected from the group consisting of [1] a C1-8 alkyl group and [2] a C1-8 alkoxy group; R4 is selected from the group consisting of: (1) a hydrogen atom, (2) a C1-8 alkyl group which may be substituted by halogen atom(s), (3) a C3-8 cycloalkyl group, (4) a cyano group, (5) an aminocarbonyl group, (6) a hydroxycarbonyl group, (7) a halogen atom, (8) a (C1-8 alkyl)m4b-amino group, m4b: 0˜2, (9) a hydroxy group, and (10) a C1-8 alkoxy group which may be substituted by hydroxy group(s); R5 is selected from the group consisting of: (1) a hydrogen atom, (2) a C1-8 alkyl group which may be substituted by one or more R5A, R5A: [1] a hydroxycarbonyl group, [2] a C1-8 alkoxycarbonyl group, [3] a hydroxy group, [4] a C1-8 alkoxy group, [5] a (C1-8 alkyl)m5-amino group, or [6] a C1-8 alkylthio group, m5: 0˜2, and (3) a C1-8 alkylsulfonyl group; R6 and R6′ are each independently: (1) a C1-8 alkyl group, or R6 and R6′ are taken together with the carbon atoms to which they are bound to form, (2) a C3-8 cycloalkyl group, or (3) a 4- to 10-membered heterocycloalkyl group; R7 is selected from the group consisting of: (1) a hydrogen atom, (2) a halogen atom, and (3) a C1-8 alkoxy group which may be substituted by one or more R7A, R7A: [1] a (C1-8 alkyl)m7a-amino group, or [2] a hydroxy group, m7a:0˜2; R8 is selected from the group consisting of: (1) a hydrogen atom, (2) a C1-8 alkyl group which may be substituted by one or more R8A, R8A: [1] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R8A1, [2] a (C1-8 alkyl)m8a-amino group which may be substituted by a halogen atom, or [3] a hydroxy group, m8a:0˜2, R8A1: [1] a C1-8 alkyl group, [2] a C1-8 alkylsulfonyl group, [3] a (C1-8 alkyl)m8b-aminosulfonyl group, or [4] an oxo group, m8b: 0˜2, (3) a C2-8 alkenyl group, (4) a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R8B, R8B: <1> a C1-8 alkyl group which may be substituted by one or more R8B1, <2> a C2-8 alkynyl group, <3> a C3-8 cycloalkyl group which may be substituted by [1] cyano group(s) or [2] C1-8 alkyl group(s), <4> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R8B2, <5> a C1-8 alkoxy group which may be substituted by substituent(s) selected from the group consisting of [1] a C1-8 alkoxy group and [2] a C3-8 cycloalkyl group, <6> a C1-8 alkylsulfonyl group, <7> an oxo group, <8> a cyano group, <9> a C1-8 alkanoyl group which may be substituted by one or more R8B3, <10> a C3-8 cycloalkylcarbonyl group, <11> a (C1-8 alkyl)m8c-aminosulfonyl group, <12> a C1-8 alkylsulfonyl (C0-8 alkyl) amino group, <13> a (C1-8 alkyl)m8d-amino group which may be substituted by one or more R8B4, <14> a hydroxy group, or <15> a (C1-8 alkyl)m8e-aminocarbonyl group, m8c: 0˜2, m8d: 0˜2, m8e: 0˜2, R8B1: [1] a C3-8 cycloalkyl group, [2] a hydroxy group, or [3] C1-8 alkoxy group, R8B2: [1] a halogen atom, [2] a C1-8 alkyl group, [3] an oxo group, or [4] a hydroxy group, R8B3: a (C1-8 alkyl)m8f-amino group, m8f: 0˜2, R8B4: [1] a C3-8 cycloalkyl group, or [2] a hydroxy group, (5) a 5- to 14-membered heteroaryl group which may be substituted by a C1-8 alkyl group, (6) a (C1-8 alkyl)m8g-aminocarbonyl group which may be substituted by one or more R8C, m8g: 0˜2, R8C: [1] a hydroxy group, [2] a (C1-8 alkyl)m8h-amino group which may be substituted by substituent(s) selected from the group consisting of <1> a (C1-8 alkyl)m8i-aminosulfonyl group and <2> a C1-8 alkylsulfonyl group, or [3] a C1-8 alkylsulfonyl group, m8h: 0˜2, m8i: 0˜2, (7) a 4- to 10-membered heterocycloalkyl (C0-8 alkyl) aminocarbonyl group which may be substituted by oxo group(s), (8) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by one or more R8D, R8D: [1] a C1-8 alkyl group which may be substituted by one or more R8D1, [2] a hydroxy group, or [3] a C1-8 alkylsulfonyl group, R8D1: [1] a hydroxy group, or [2] a C1-8 alkoxy group, (9) a hydroxycarbonyl group, (10) a C0-8 alkoxy (C0-8 alkyl) aminocarbonyl group which may be substituted by hydroxy group(s), (11) a halogen atom, (12) a (C1-8 alkyl)m8j-amino group which may be substituted by 4- to 10-membered heterocycloalkyl group(s), m8j: 0˜2, (13) a hydroxyl group, (14) a C1-8 alkoxy group which may be substituted by one or more R8E, R8E: <1> a hydroxy group, <2> a C1-8 alkoxycarbonyl group, <3> a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by one or more R8E1, <4> a (C1-8 alkyl)m8k1-amino group which may be substituted by one or more R8E2, m8k1: 0˜2, <5> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R8E3, <6> a 5- to 14-membered heteroaryl group, <7> a (C1-8 alkyl)m8k2-aminocarbonyl group which may be substituted by one or more R8E6 m8k2: 0˜2, <8> a C1-8 alkoxy group which may be substituted by one or more R8E7, <9> a C1-8 alkylthio group, <10> a C1-8 alkylsulfinyl group, or <11> a C1-8 alkylsulfonyl group, R8E1: <1> a C1-8 alkoxycarbonyl group, <2> a C1-8 alkanoyl group, <3> a C1-8 alkylsulfonyl group, <4> a (C1-8 alkyl)m8k3-aminosulfonyl group m8k3: 0˜2, or <5> a 4- to 10-membered heterocycloalkyl group, R8E2: <1> a hydroxy group, <2> a C1-8 alkoxycarbonyl group, <3> a C3-8 cycloalkyl group which may be substituted by C1-8 alkyl group(s) which may be substituted by hydroxy group(s), <4> a C1-8 alkanoyl group which may be substituted by substituent(s) selected from the group consisting of [1] a (C1-8 alkyl)m8k4-amino group and [2] a halogen atom, m8k4: 0˜2, <5> a (C1-8 alkyl)m8k5-aminocarbonyl group, m8k5: 0˜2, <6> a C1-8 alkylsulfonyl group, <7> a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyl group which may be substituted by C1-8 alkyl group(s), <8> a (C1-8 alkyl)m8k6-aminosulfonyl group, m8k6: 0˜2, or R8E3: <1> a C1-8 alkyl group which may be substituted by substituent(s) selected from the group consisting of [1] a hydroxy group and [2] a C1-8 alkylcarbonyloxy group, <2> a hydroxy group, <3> a C3-8 cycloalkyl group, <4> a C1-8 alkylsulfonyl group, <5> a (C1-8 alkyl)m8k8-aminocarbonyl group, m8k8: 0˜2, <6> a C1-8 alkanoyl group which may be substituted by hydroxy group(s), <7> an oxo group, or <8> a 4- to 10-membered heterocycloalkyl group which may be substituted by substituent(s) selected from the group consisting of [1] a C1-8 alkanoyl group, and [2] a C1-8 alkylsulfonyl group, R8E6: <1> a C2-8 alkenylcarbonyloxy group, <2> a hydroxy group, <3> a cyano group, <4> a (C1-8 alkyl)m8k9-amino group which may be substituted by hydroxy group(s), m8k9: 0˜2, <5> a C1-8 alkoxy group which may be substituted by hydroxy group(s), <6> a 4- to 10-membered heterocycloalkyl group which may be substituted by C1-8 alkyl group(s), or <7> a 5- to 14-membered heteroaryl group, R8E7: <1> a hydroxy group, or <2> a C1-8 alkoxy group which may be substituted by hydroxy group(s), (15) a 4- to 10-membered heterocycloalkyloxy group which may be substituted by one or more R8F: R8F: <1> a C1-8 alkyl group which may be substituted by one or more R8F1, <2> a C3-8 cycloalkyl group, <3> a C1-8 alkanoyl group which may be substituted by halogen atom(s), <4> a C1-8 alkoxycarbonyl group, <5> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R8F2, <6> a C1-8 alkyl sulfonyl group, or <7> a hydroxy group, R8F1: [1] a hydroxy group, [2] a C1-8 alkoxy group, or [3] a halogen atom, R8F2: [1] a 4- to 10-membered heterocycloalkyl group, [2] a C1-8 alkoxycarbonyl group, or [3] a C1-8 alkylsulfonyl group, (16) a 5- to 14-membered heteroaryloxy group, (17) a (C1-8 alkyl)m8l1-aminosulfonyloxy group, m8l1: 0˜2, (18) a C1-8 alkylthio group which may be substituted by (C1-8 alkyl)m8l2-amino group(s), m8l2: 0˜2, (19) a C1-8 alkylsulfonyl group which may be substituted by one or more R8G, R8G: [1] a hydroxycarbonyl group, [2] a hydroxy group, or [3] a (C1-8 alkyl)m8l3-amino group, m8l3: 0˜2, (20) a C2-8 alkenyloxy group, and (21) a C1-8 alkylsulfonyloxy group which may be substituted by halogen atom(s); R9 is selected from the group consisting of: (1) a hydrogen atom, (2) a C1-8 alkyl group which may be substituted by one or more R9A, R9A: [1] a C3-8 cycloalkyl group, [2] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R9A1, [3] a hydroxy group, or [4] a C1-8 alkoxy group, R9A1: [1] a C1-8 alkyl group, [2] a C3-8 cycloalkyl group, or [3] a 4- to 10-membered heterocycloalkyl group, (3) a C2-8 alkenyl group, (4) a C2-8 alkynyl group which may be substituted by one or more R9C, R9C: [1] a C1-8 alkoxy group, [2] a (C1-8 alkyl)m9b-amino group which may be substituted by C6-10 aryl group(s), [3] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R9C1, [4] a C3-8 cycloalkyl group, [5] a hydroxy group, or [6] a hydroxycarbonyl group, m9b: 0˜2, R9C1: [1] a C3-8 cycloalkyl group, [2] a 4- to 10-membered heterocycloalkyl group, or [3] an oxo group, (5) a C3-8 cycloalkyl group, (6) a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R9D, R9D: [1] a C1-8 alkyl group which may be substituted by 4- to 10-membered heterocycloalkyl group(s), [2] a C3-8 cycloalkyl group, [3] a 4- to 10-membered heterocycloalkyl group, or [4] a C1-6 alkylsulfonyl group, (7) a C6-10 aryl group which may be substituted by one or more R9E, R9E: [1] a halogen atom, [2] a hydroxy group, [3] a hydroxycarbonyl group, or [4] a C1-8 alkyl group which may be substituted by hydroxy group(s), (8) a 5- to 14-membered heteroaryl group which may be substituted by C1-8 alkyl group(s), (9) a cyano group, (10) a C1-8 alkanoyl group, (11) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by C1-8 alkyl group(s), (12) a halogen atom, (13) a (C1-8 alkyl)m9c-amino group, m9c: 0˜2, (14) a C1-8 alkylcarbonyl(C0-8 alkyl)amino group which may be substituted by (C1-8 alkyl)m9d-amino group(s), m9d: 0˜2, (15) a C1-8 alkylsulfonyl(C0-8 alkyl)amino group, (16) a (C1-8 alkyl)m9e-aminosulfonyl(C0-8 alkyl)amino group, m9e: 0˜2, (17) a nitro group, (18) a hydroxy group, (19) a C1-8 alkoxy group which may be substituted by one or more R9G, R9G: [1] a hydroxy group, [2] a hydroxycarbonyl group, [3] a C6-10 aryl group which may be substituted by C1-8 alkoxy group(s), [4] a (C1-8 alkyl)m9g1-amino group, [5] a C1-8 alkoxy group which may be substituted by one or more R9G1, or [6] a 5- to 14-membered heteroaryl group, m9g1: 0˜2, R9G1: [1] a C1-8 alkoxy group, or [2] a hydroxycarbonyl group, (20) a 4- to 10-membered heterocycloalkyloxy group which may be substituted by 4- to 10-membered heterocycloalkyl group(s), (21) a C1-8 alkylthio group which may be substituted by (C1-8 alkyl)m9f-amino group(s), m9f: 0˜2, (22) a C1-8 alkylsulfonyl group which may be substituted by (C1-8 alkyl)m9g-amino group(s), m9g: 0˜2, (23) a (C1-8 alkyl)m9h-aminosulfonyl group, m9h: 0˜2, and (24) a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyl group which may be substituted by C1-8 alkyl group(s); R10 represents [1] a hydrogen atom, or [2] a 4- to 10-membered heterocycloalkyl group which may be substituted by 4- to 10-membered heterocycloalkyl group(s). 6. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is selected from the group consisting of 9-(4-isopropyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-9-prop-1-ynyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 9-cyclopropylethynyl-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 6,6-dimethyl-8-(1-oxetan-3-yl-piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 9-bromo-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 9-bromo-8-(4-cyclopropyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 9-chloro-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-cyclobutyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-9-prop-1-ynyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 6,6,9-trimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 9-ethyl-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 9-ethynyl-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-cyclobutyl-piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 9-ethynyl-6,6-dimethyl-11-oxo-8-(4-pyrrolidin-1-yl-piperidin-1-yl)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 6,6-dimethyl-11-oxo-8-(4-pyrrolidin-1-yl-piperidin-1-yl)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-cyclobutyl-piperazin-1-yl)-9-ethynyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-cyclobutyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-9-propyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(1-isopropyl-piperidin-4-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-isopropyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-cyclobutyl-piperazin-1-yl)-9-cyclopropyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(2-tert-butylamino-ethoxy)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 9-ethynyl-8-(4-methanesulfonyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 9-bromo-8-(4-cyclobutyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-9-propyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; and 9-ethynyl-6,6-dimethyl-8-morpholin-4-yl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 7. The pharmaceutical of claim 1, wherein the pharmaceutical is for the treatment of cancer or cancer metastasis. 8. The pharmaceutical of claim 7, wherein the cancer is selected from the group consisting of lung cancer, anaplastic large cell lymphoma, inflammatory myofibroblastic tumor, esophageal cancer, and neuroblastoma. 9. The pharmaceutical of claim 1, wherein the pharmaceutical is for the treatment of depression. 10. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 9-(4-isopropyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 11. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-9-prop-1-ynyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 12. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 9-cyclopropylethynyl-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6, 11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 13. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 6,6-dimethyl-8-(1-oxetan-3-yl-piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 14. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 9-bromo-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 15. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 9-bromo-8-(4-cyclopropyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 16. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 9-chloro-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 17. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 8-(4-cyclobutyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-9-prop-1-ynyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 18. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 6,6,9-trimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 19. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 9-ethyl-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 20. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 21. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 9-ethynyl-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 22. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 8-(4-cyclobutyl-piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 23. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 9-ethynyl-6,6-dimethyl-11-oxo-8-(4-pyrrolidin-1-yl-piperidin-1-yl)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 24. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 6,6-dimethyl-11-oxo-8-(4-pyrrolidin-1-yl-piperidin-1-yl)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 25. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 8-(4-cyclobutyl-piperazin-1-yl)-9-ethynyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 26. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 8-(4-cyclobutyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-9-propyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 27. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 8-(1-isopropyl-piperidin-4-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 28. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 8-(4-isopropyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 29. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 8-(4-cyclobutyl-piperazin-1-yl)-9-cyclopropyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 30. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 8-(2-tert-butylamino-ethoxy)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 31. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 9-ethynyl-8-(4-methanesulfonyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 32. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 9-bromo-8-(4-cyclobutyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 33. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-9-propyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. 34. The pharmaceutical of claim 1, wherein the compound represented by Formula (I) is 9-ethynyl-6,6-dimethyl-8-morpholin-4-yl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.