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|Title:||Ophthalmologic irrigation solutions and method|
|Abstract:||Solutions for perioperative intraocular application by continuous irrigation during ophthalmologic procedures are provided. These solutions include multiple agents that act to inhibit inflammation, inhibit pain, effect mydriasis (dilation of the pupil), and/or decrease intraocular pressure, wherein the multiple agents are selected to target multiple molecular targets to achieve multiple differing physiologic functions, and are included in dilute concentrations in a balanced salt solution carrier.|
|Inventor(s):||Demopulos; Gregory A. (Mercer Island, WA), Palmer; Pamela Pierce (San Francisco, CA), Herz; Jeffrey M. (Mill Creek, WA)|
|Assignee:||Omeros Corporation (Seattle, WA)|
1. A composition for use in an intraocular ophthalmologic procedure, comprising
an anti-inflammatory agent and a mydriatic agent in a physiologic irrigation solution for intraocular delivery, wherein the anti-inflammatory agent comprises ketorolac and the mydriatic agent comprises phenylephrine, wherein the ketorolac and
phenylephrine are included at concentrations less than that used for conventional topical or systemic delivery and in a therapeutically effective amount for the maintenance of pupil dilation and inhibition of miosis during the procedure and the reduction
of postoperative pain when delivered intraocularly during the intraocular ophthalmologic procedure.
2. The composition of claim 1, wherein the wherein the ketorolac is included in the solution at a concentration of no more than 100,000 nanomolar and the phenylephrine is included in the solution at a concentration of no more than 500,000 nanomolar.
3. The composition of claim 1, wherein the pH of e irrigation solution is between 5.5 and 8.0.