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Summary for Patent: 9,399,014
|Title:||Pharmaceutical topical compositions|
|Abstract:||The invention provides pharmaceutical stable semisolid topical compositions comprising between 0.2 to 5% of a des-fluoroquinolone compound, and a suitable carrier to manufacture an ointment or a cream.|
|Inventor(s):||Tarrago; Cristina (Esplugues del Llobregat, ES), Santos; Benjamin (Barcelona, ES), Raga; Manuel (Barcelona, ES), Guglietta; Antonio (Molins de Rei, ES)|
|Assignee:||FERRER INTERNACIONAL, S.A. (Barcelona, ES)|
1. A method of treatment of skin and skin structure bacterial infections caused by S. aureus or S. pyrogenes comprising: administering a stable topical cream
composition to a subject in need thereof, said stable composition comprising: a) 0.2-5% of ozenoxacin, and b) a suitable carrier comprising: b.1) 15-25% of one or more emulsifiers selected from the group consisting of ethylene glycol monostearate,
sorbitan tristearate, a mixture of PEG6 stearate, glycol stearate and PEG32 stearate, and hydrogenated lecithin, and mixtures thereof; b.2) 10-20% of one or more surfactants selected from the group consisting of sorbitan oleate monoolein/propylene
glycol, C.sub.8C.sub.10 fatty acid mono- and diglycerides from coconut oil, soy lecithin, egg phosphatides, citric acid esters of monoglycerides, lactic acid esters of monoglycerides, diacetyl tartaric acid esters of monoglycerides, succinic acid esters
of monoglycerides, sucrose fatty acid esters, polyglycolyzed glycerides of oleic acids, polyglycolyzed glycerides of linoleic acid, polyglycerol esters of fatty acids, and polyglyceryl esters of mixed fatty acids, and mixtures thereof; b.3) 5-15% of an
oil component which is the Guerbet alcohol 2-octyl dodecanol; b.4) 1-10% of one or more low melting point waxes selected from the group consisting of fatty alcohols having 8 to 30 carbon atoms and mixtures thereof; b.5) water; b.6) 10-20% of one or
more water dispersible components selected from the group consisting of polyethylene glycol 400, hexylene glycol, propylene glycol, polypropylene glycol-10 methylglucose ether, ethoxydiglycol, polyethylene glycol-6 caprylic/capric glyceride, ethylene
glycol monobutyl ether, polyethylene glycol-8 caprylic/capric glycerides, 3-methoxy-3-methyl-1-butanol, dimethyl isosorbide, and mixtures thereof; and b.7) 0.01-1% of one or more non-formaldehyde-donating preservatives; wherein the amount of component
b.5 is an amount to complete 100 percent by weight and all percentages being weight percent and based on the total weight of the composition.
2. The method of treatment of skin and skin structure infections according to claim 1, wherein the skin and skin structure infection is impetigo.
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