➤ Get the DrugPatentWatch Daily Briefing

Get Daily Updates on Generic Entry, Litigation, Biosimilars, and more …

Serving leading biopharmaceutical companies globally:

Medtronic
Boehringer Ingelheim
Merck
Express Scripts
McKesson
Dow

Last Updated: March 7, 2021

DrugPatentWatch Database Preview

Claims for Patent: 9,393,210

➤ Get the DrugPatentWatch Daily Briefing
» See Plans and Pricing

« Back to Dashboard

Summary for Patent: 9,393,210
Title:Capsules containing high doses of levodopa for pulmonary use
Abstract: The present invention provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L. The invention further provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L wherein the capsule material comprises hydroxypropylmethylcellulose (HPMC) and titanium dioxide.
Inventor(s): Kee; Kevin D. (Somerville, MA), Penachio; Ernest D. (Haverhill, MA), Kamerkar; Abhijit (Boston, MA), Lipp; Michael M. (Framingham, MA), Batycky; Richard P. (Newton, MA)
Assignee: Civitas Therapeutics, Inc. (Chelsea, MA)
Application Number:14/575,454
Patent Claims: 1. A capsule for use in an inhalation device, wherein the capsule is filled with a dry powder comprising levodopa; wherein the capsule's shell comprises hydroxypropyl methylcellulose and titanium dioxide, and wherein the dry powder comprises a fine particle fraction of at least 50% of the nominal powder dose.

2. The capsule of claim 1, wherein the dry powder comprises from about 2% to about 8% of water by weight.

3. The capsule of claim 2, wherein the dry powder comprises from about 5% to about 6% of water by weight.

4. The capsule of claim 1, wherein the capsule is a 00 size capsule.

5. The capsule of claim 4, wherein the dry powder comprises between about 15 milligrams and 50 milligrams of levodopa.

6. The capsule of claim 5, wherein the dry powder comprises between about 25 milligrams and 35 milligrams of levodopa.

7. The capsule of claim 1, wherein the dry powder further comprises a salt.

8. The capsule of claim 7, wherein said salt is sodium chloride.

9. The capsule of claim 1, wherein the dry powder further comprises a phospholipid.

10. The capsule of claim 9, wherein said phospholipid is dipalmitoylphosphatidylcholine (DPPC).

11. The capsule of claim 1, wherein the dry powder further comprises DPPC and sodium chloride.

12. The capsule of claim 1, wherein the dry powder comprises a fine particle fraction between about 50% to about 70% of the total amount of powder in the capsule.

13. The capsule of claim 1, wherein the capsule is filled with about 30 milligrams to about 50 milligrams of dry powder.

14. The capsule of claim 1, wherein the dry powder has a working density between about 0.02 g/cm.sup.3 to about 0.1 g/cm.sup.3.

15. The capsule of claim of claim 1, wherein the dry powder has a working density between about 0.02 g/cm.sup.3 to about 0.05 g/cm.sup.3.

Make Better Decisions: Try a trial or see plans & pricing

Serving leading biopharmaceutical companies globally:

Colorcon
Express Scripts
Dow
Johnson and Johnson
AstraZeneca
Moodys

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.