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Last Updated: February 20, 2020

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Claims for Patent: 9,393,210


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Summary for Patent: 9,393,210
Title:Capsules containing high doses of levodopa for pulmonary use
Abstract: The present invention provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L. The invention further provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L wherein the capsule material comprises hydroxypropylmethylcellulose (HPMC) and titanium dioxide.
Inventor(s): Kee; Kevin D. (Somerville, MA), Penachio; Ernest D. (Haverhill, MA), Kamerkar; Abhijit (Boston, MA), Lipp; Michael M. (Framingham, MA), Batycky; Richard P. (Newton, MA)
Assignee: Civitas Therapeutics, Inc. (Chelsea, MA)
Application Number:14/575,454
Patent Claims: 1. A capsule for use in an inhalation device, wherein the capsule is filled with a dry powder comprising levodopa; wherein the capsule's shell comprises hydroxypropyl methylcellulose and titanium dioxide, and wherein the dry powder comprises a fine particle fraction of at least 50% of the nominal powder dose.

2. The capsule of claim 1, wherein the dry powder comprises from about 2% to about 8% of water by weight.

3. The capsule of claim 2, wherein the dry powder comprises from about 5% to about 6% of water by weight.

4. The capsule of claim 1, wherein the capsule is a 00 size capsule.

5. The capsule of claim 4, wherein the dry powder comprises between about 15 milligrams and 50 milligrams of levodopa.

6. The capsule of claim 5, wherein the dry powder comprises between about 25 milligrams and 35 milligrams of levodopa.

7. The capsule of claim 1, wherein the dry powder further comprises a salt.

8. The capsule of claim 7, wherein said salt is sodium chloride.

9. The capsule of claim 1, wherein the dry powder further comprises a phospholipid.

10. The capsule of claim 9, wherein said phospholipid is dipalmitoylphosphatidylcholine (DPPC).

11. The capsule of claim 1, wherein the dry powder further comprises DPPC and sodium chloride.

12. The capsule of claim 1, wherein the dry powder comprises a fine particle fraction between about 50% to about 70% of the total amount of powder in the capsule.

13. The capsule of claim 1, wherein the capsule is filled with about 30 milligrams to about 50 milligrams of dry powder.

14. The capsule of claim 1, wherein the dry powder has a working density between about 0.02 g/cm.sup.3 to about 0.1 g/cm.sup.3.

15. The capsule of claim of claim 1, wherein the dry powder has a working density between about 0.02 g/cm.sup.3 to about 0.05 g/cm.sup.3.

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Serving leading biopharmaceutical companies globally:

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