Claims for Patent: 9,309,234

Summary for Patent: 9,309,234

Title:	Opioid receptor ligands and methods of using and making same
Abstract:	This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
Inventor(s):	Yamashita; Dennis (Cambridge, MA), Gotchev; Dimitar (Hatboro, PA), Pitis; Philip (North Wales, PA), Chen; Xiao-Tao (Furlong, PA), Liu; Guodong (Jamison, PA), Yuan; Catherine C. K. (King of Prussia, PA)
Assignee:	Trevena, Inc. (King of Prussia, PA)
Application Number:	14/712,974
Patent Claims:	1. A compound having a formula of ##STR00222## or a pharmaceutically acceptable salt thereof, wherein: R.sub.21 and R.sub.22 are independently H or CH.sub.3; D.sub.1 is an optionally substituted aryl; B.sub.3 is H or optionally substituted alkyl; and B.sub.5 is an optionally substituted thiophenyl. 2. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein D.sub.1 is an optionally substituted phenyl or an optionally substituted pyridyl. 3. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein D.sub.1 is pyridyl. 4. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein D.sub.1 is 2-pyridyl. 5. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein B.sub.5 is an optionally substituted thiophenyl selected from the group consisting of ##STR00223## 6. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein B.sub.5 is ##STR00224## wherein R.sub.23, R.sub.24, and R.sub.30 are each independently H, OH, cycle, aryl, branched or unbranched alkyl alcohol, halo, branched or unbranched alkyl, amide, cyano, alkoxy, haloalkyl, aklylsulfonyl, nitrite, alkylsulfanyl; or R.sub.23 and R.sub.24 together form an aryl or cycle that is attached to one or more of the atoms of B.sub.5. 7. The compound of claim 6, or a pharmaceutically acceptable salt thereof, wherein R.sub.23, R.sub.24, and R.sub.30 are each independently H, NH.sub.2, OH, Cl, Br, F, I, OMe, CN, CH.sub.3, phenyl, C.sub.3-C.sub.6 carbocycle, methanesulfonyl, CF.sub.3, ##STR00225## wherein R.sub.29 is H or an optionally substituted branched or unbranched alkyl. 8. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein B.sub.5 is ##STR00226## wherein R.sub.23 and R.sub.24 are each independently H, OH, cycle, aryl, branched or unbranched alkyl alcohol, halo, branched or unbranched alkyl, amide, cyano, alkoxy, haloalkyl, aklylsulfonyl, nitrite, alkylsulfanyl; or R.sub.23 and R.sub.24 together form an aryl or cycle that is attached to one or more of the atoms of B.sub.5. 9. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein B.sub.5 is ##STR00227## wherein R.sub.23 is H, OH, cycle, aryl, branched or unbranched alkyl alcohol, halo, branched or unbranched alkyl, amide, cyano, alkoxy, haloalkyl, aklylsulfonyl, nitrite, or alkylsulfanyl. 10. The compound of claim 9, or a pharmaceutically acceptable salt thereof, wherein R.sub.23 is alkoxy. 11. The compound of claim 10, or a pharmaceutically acceptable salt thereof, wherein R.sub.23 is methoxy. 12. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein B.sub.3 is H or C.sub.1-C.sub.5 alkyl. 13. The compound of claim 1 having a formula of ##STR00228## or a pharmaceutically acceptable salt thereof, wherein D.sub.1 is an optionally substituted aryl; B.sub.3 is H or optionally substituted alkyl B.sub.5 is an optionally substituted thiophenyl. 14. The compound of claim 13, or a pharmaceutically acceptable salt thereof, wherein D.sub.1 is an optionally substituted phenyl or an optionally substituted pyridyl. 15. The compound of claim 13, or a pharmaceutically acceptable salt thereof, wherein D.sub.1 is pyridyl. 16. The compound of claim 13, or a pharmaceutically acceptable salt thereof, wherein D.sub.1 is 2-pyridyl. 17. The compound of claim 13, or a pharmaceutically acceptable salt thereof, wherein B.sub.5 is ##STR00229## wherein R.sub.23 and R.sub.24 are each independently H, OH, cycle, aryl, branched or unbranched alkyl alcohol, halo, branched or unbranched alkyl, amide, cyano, alkoxy, haloalkyl, aklylsulfonyl, nitrite, alkylsulfanyl; or R.sub.23 and R.sub.24 together form an aryl or cycle that is attached to one or more of the atoms of B.sub.5. 18. The compound of claim 13, or a pharmaceutically acceptable salt thereof, wherein B.sub.5 is ##STR00230## wherein R.sub.23 is H, OH, cycle, aryl, branched or unbranched alkyl alcohol, halo, branched or unbranched alkyl, amide, cyano, alkoxy, haloalkyl, aklylsulfonyl, nitrite, or alkylsulfanyl. 19. The compound of claim 18, or a pharmaceutically acceptable salt thereof, wherein R.sub.23 is alkoxy. 20. The compound of claim 13, or a pharmaceutically acceptable salt thereof, wherein B.sub.3 is H or C.sub.1-C.sub.5 alkyl. 21. The compound of claim 15, or a pharmaceutically acceptable salt thereof, wherein B.sub.3 is H or C.sub.1-C.sub.5 alkyl. 22. The compound of claim 21, or a pharmaceutically acceptable salt thereof, wherein B.sub.5 is ##STR00231## wherein R.sub.23 is H, OH, cycle, aryl, branched or unbranched alkyl alcohol, halo, branched or unbranched alkyl, amide, cyano, alkoxy, haloalkyl, aklylsulfonyl, nitrite, or alkylsulfanyl. 23. The compound of claim 22, or a pharmaceutically acceptable salt thereof, wherein R.sub.23 is alkoxy. 24. The compound of claim 23, or a pharmaceutically acceptable salt thereof, wherein R.sub.23 is methoxy. 25. A pharmaceutically acceptable salt of a compound having a formula of ##STR00232## 26. The pharmaceutically acceptable salt of claim 25, wherein the salt is a pharmaceutically acceptable salt of a compound having a formula of ##STR00233## 27. A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and pharmaceutically acceptable carrier. 28. A pharmaceutical composition comprising a compound of claim 13, or a pharmaceutically acceptable salt thereof, and pharmaceutically acceptable carrier. 29. A method of treating pain comprising administering to a subject the compound of claim 1, or a pharmaceutically acceptable salt thereof. 30. A method of treating pain comprising administering to a subject the compound of claim 13, or a pharmaceutically acceptable salt thereof. 31. A method of treating pain comprising administering to a subject or a subject in need thereof the pharmaceutically acceptable salt of claim 25.