Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Compositions and methods for treating diseases of the nail|
|Abstract:||Methods and compositions for treating disorders of the nail and nail bed. Such compositions contain a vehicle in which all components of the composition are dissolved, suspended, dispersed, or emulsified, a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient that is soluble in the non-volatile solvent and/or a mixture of the vehicle and the non-volatile solvent, which composition has a surface tension of 40 dynes/cm or less and has continuing spreadability, and which composition is effective in treating a disorder of the nail or nail bed.|
|Inventor(s):||Winckle; Gareth (Petaluma, CA), Fieldson; Gregory T. (Morgantown, WV)|
|Assignee:||Dow Pharmaceutical Sciences, Inc. (Petaluma, CA)|
1. A pharmaceutical composition for the topical treatment of a disorder of the nail or nail bed comprising a. ethanol, 50% to 70% (w/w), b. cyclomethicone, 10% to 15%
(w/w), c. diisopropyl adipate, 8% to 15% (w/w), d. C12-15 alkyl lactate, 8% to 15% (w/w), e. antioxidant, 0.001% to 0.50% (w/w), and f. (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4- -triazole-1-yl)butane-2-ol, 2% to 15%
(w/w); wherein the composition is formulated as a solution; wherein the surface tension of the composition is 40 dynes/cm or less; and wherein the composition does not comprise a polymeric film forming compound.
2. The pharmaceutical composition of claim 1 comprising (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4- -triazole-1-yl)butane-2-ol in an amount of about 10%.
3. The pharmaceutical composition of claim 1, wherein the surface tension of the composition is 30 dynes/cm or less.
4. The pharmaceutical composition of claim 1 comprising (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4- -triazole-1-yl)butane-2-ol in an amount of about 10%, and wherein the surface tension of the composition is 25 dynes/cm or less.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.