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Harvard Business School
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Generated: August 22, 2017

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Title:Azacyclic compounds
Abstract: Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is adminstered to a patient in need of such treatment.
Inventor(s): Andersson; Carl-Magnus A. (Glostrup, DK), Croston; Glenn (San Diego, CA), Hansen; Eva Louise (Glostrup, DK), Uldam; Allan Kjaersgaard (Glostrup, DK)
Assignee: ACADIA PHARMACEUTICALS INC. (San Diego, CA)
Application Number:14/628,156
Patent Claims: 1. A compound of formula (I) ##STR00010## or a pharmaceutically acceptable salt thereof, wherein Z is ##STR00011## in which R is a hydrogen, a lower alkyl group, a cyclic organyl group, or a substituted or unsubstituted aralkyl or heteroaralkyl group; and n is 1; X.sub.1 is NH or N(lower alkyl) group; X.sub.2 is methylene; Y.sub.1 is methylene; Y.sub.2 is a bond, methylene, ethylene, or vinylene; Ar.sub.1 and Ar.sub.e are phenyl groups p-substituted with a substituent selected from the group consisting of lower alkyl, lower alkoxy and halogen; and W is oxygen.

2. The compound or pharmaceutically acceptable salt of claim 1, wherein R is a lower alkyl group.

3. The compound or pharmaceutically acceptable salt of claim 2, wherein R is selected from the group consisting of methyl, ethyl, propyl, butyl, methylbutyl, cyclopropyl, cyclohexyl, iso-propyl and tert-butyl.

4. The compound or pharmaceutically acceptable salt of claim 2, wherein aR.sub.1 and Ar.sub.2 are p-substituted with different substituents.
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Serving 500+ biopharmaceutical companies globally:

Daiichi Sankyo
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Covington
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Merck

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