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|Abstract:||Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is adminstered to a patient in need of such treatment.|
|Inventor(s):||Andersson; Carl-Magnus A. (Glostrup, DK), Croston; Glenn (San Diego, CA), Hansen; Eva Louise (Glostrup, DK), Uldam; Allan Kjaersgaard (Glostrup, DK)|
|Assignee:||ACADIA PHARMACEUTICALS INC. (San Diego, CA)|
1. A compound of formula (I) ##STR00010## or a pharmaceutically acceptable salt thereof, wherein Z is ##STR00011## in which R is a hydrogen, a lower alkyl group, a cyclic organyl
group, or a substituted or unsubstituted aralkyl or heteroaralkyl group; and n is 1; X.sub.1 is NH or N(lower alkyl) group; X.sub.2 is methylene; Y.sub.1 is methylene; Y.sub.2 is a bond, methylene, ethylene, or vinylene; Ar.sub.1 and Ar.sub.e are
phenyl groups p-substituted with a substituent selected from the group consisting of lower alkyl, lower alkoxy and halogen; and W is oxygen.
2. The compound or pharmaceutically acceptable salt of claim 1, wherein R is a lower alkyl group.
3. The compound or pharmaceutically acceptable salt of claim 2, wherein R is selected from the group consisting of methyl, ethyl, propyl, butyl, methylbutyl, cyclopropyl, cyclohexyl, iso-propyl and tert-butyl.
4. The compound or pharmaceutically acceptable salt of claim 2, wherein aR.sub.1 and Ar.sub.2 are p-substituted with different substituents.