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Claims for Patent: 9,289,446

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Claims for Patent: 9,289,446

Title:Myocardial perfusion imaging methods and compositions
Abstract: A myocardial imaging method that is accomplished by administering one or more adenosine A.sub.2A adenosine receptor agonist to a human undergoing myocardial imaging as well as pharmaceutical compositions comprising at least one A.sub.2a receptor agonist, at least one liquid carrier, and at least one co-solvent.
Inventor(s): Belardinelli; Luiz (Palo Alto, CA), Rosner; Mitchell (Mountain View, CA)
Assignee: Gilead Sciences, Inc. (Foster City, CA)
Application Number:14/533,025
Patent Claims: 1. A pharmaceutical composition comprising: a) about 400 .mu.g of a compound which has the formula: ##STR00020## b) at least one liquid carrier selected from the group consisting of water, saline, a buffer, and combinations thereof, c) at least one sodium phosphate buffer; d) EDTA; and e) propylene glycol in an amount of about 15% (w:v), wherein the pH of said pharmaceutical composition is from about 6 to about 8.

2. The pharmaceutical composition of claim 1, wherein the pH of said pharmaceutical composition is about 7.

3. The pharmaceutical composition of claim 1, wherein at least one liquid carrier is water.

4. The pharmaceutical composition of claim 3, wherein the water is distilled water or de-ionized water.

5. The pharmaceutical composition of claim 3 comprising 15% (w:v) propylene glycol and 100 mM phosphate buffer at pH 7 with 0.1% EDTA.

6. The pharmaceutical composition of claim 1, wherein the at least one sodium phosphate buffer is of a concentration of about 100 mM.

7. The pharmaceutical composition of claim 1 comprising 15% (w:v) propylene glycol and 100 mM phosphate buffer at pH 7 with 0.1% EDTA.

8. A kit comprising a vessel and the pharmaceutical composition of claim 1, wherein the pharmaceutical composition is contained within the vessel, and wherein the vessel is formed from either type I glass or plastic.

9. The kit of claim 8, wherein the vessel is formed from plastic.

10. A kit comprising a vessel and the pharmaceutical composition of claim 3, wherein the pharmaceutical composition is contained within the vessel, and wherein the vessel is formed from either type I glass or plastic.

11. The kit of claim 10, wherein the vessel is formed from plastic.

12. A method of producing coronary vasodilation comprising administering by intravenous (iv) bolus the pharmaceutical composition of claim 1 to a human in need thereof.

13. A method of producing coronary vasodilation comprising administering by intravenous (iv) bolus the pharmaceutical composition of claim 3 to a human in need thereof.

14. A method of myocardial perfusion imaging of a human in need thereof comprising administering by intravenous (iv) bolus the pharmaceutical composition of claim 1 and a radionuclide, wherein the myocardium is examined for areas of insufficient blood flow following administration the pharmaceutical composition and the radionuclide.

15. The method of claim 14, wherein the pharmaceutical composition and the radionuclide are administered separately.

16. The method of claim 14, wherein the pharmaceutical composition and the radionuclide are administered simultaneously.

17. The method of claim 14, wherein administration of the pharmaceutical composition causes at least a 2.5 fold increase in coronary blood flow for less than about 5 minutes.

18. The method of claim 14, wherein administration of the pharmaceutical composition causes at least a 2.5 fold increase in coronary blood flow for less than about 3 minutes.

19. A method of myocardial perfusion imaging of a human in need thereof comprising administering by intravenous (iv) bolus the pharmaceutical composition of claim 3 and a radionuclide, wherein the myocardium is examined for areas of insufficient blood flow following administration the pharmaceutical composition and the radionuclide.

20. The method of claim 19, wherein the pharmaceutical composition and the radionuclide are administered separately.
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