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|Abstract:||Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.|
|Inventor(s):||Ross; Bruce S. (El Granada, CA), Sofia; Michael Joseph (Doylestown, PA), Pamulapati; Ganapati Reddy (San Ramon, CA), Rachakonda; Suguna (Twinsburg, OH), Zhang; Hai-Ren (San Jose, CA), Chun; Byoung-Kwon (Robbinsville, NJ), Wang; Peiyuan (Totowa, NJ)|
|Assignee:||Gilead Pharmasset LLC (Foster City, CA)|
1. A crystalline compound represented by the formula (S.sub.P-4): ##STR00043## having XRPD 2.theta.-reflections (.degree.) at about: 6.1 and 12.7.
2. A pharmaceutical composition comprising the crystalline compound according to claim 1 and a pharmaceutically acceptable medium.
3. A method of treating a hepatitis C virus infection in a human comprising administering to the human an effective amount of the crystalline compound according to claim 1.
4. The method according to claim 3 further comprising administering to the human another antiviral agent.
5. A process for preparing the crystalline compound according to claim 1 comprising: exposing a second crystalline compound represented by the formula (S.sub.P-4): ##STR00044## having an XRPD diffraction pattern substantially as shown in FIG. 3 or FIG. 4 to atmospheric humidity to provide a first composition.
6. The process according to claim 5 further comprising: grinding the first composition into a powder; and allowing the powder to stand in an open vessel.
7. A process for preparing the crystalline compound according to claim 1 comprising: suspending a second crystalline compound represented by the formula (S.sub.P-4): ##STR00045## having an XRPD diffraction pattern substantially as shown in FIG. 3 or FIG. 4 in water to provide a suspension.
8. The process according to claim 7 further comprising heating the suspension.
9. The process according to claim 8 further comprising cooling the suspension.
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