|Title:||Oral formulations of deferasirox|
|Abstract:||Orally administerable deferasirox formulations are disclosed having reduced release under gastric conditions and fast release at near neutral pH or at neutral pH.|
|Inventor(s):||Ghosh; Indrajit (Hillsborough, NJ), Zhang; Jia-Ai (Skillman, NJ)|
|Assignee:||NOVARTIS AG (Basel, CH)|
1. A tablet for oral administration consisting of 90 mg deferasirox; 53.61 mg microcrystalline cellulose; 3.65 mg poly vinyl pyrrolidone K-30; 11.34 mg crospovidone; 0.16
mg poloxamer; 0.81 mg fumed silica; 2.43 mg magnesium stearate; and 4.86 mg seal-coat.
2. A tablet for oral administration consisting of 180 mg deferasirox; 107.23 mg microcrystalline cellulose; 7.29 mg poly vinyl pyrrolidone K-30; 22.68 mg crospovidone; 0.32 mg poloxamer; 1.62 mg fumed silica; 4.86 mg magnesium stearate; and 9.72 mg seal-coat.
3. A tablet for oral administration consisting of 360 mg deferasirox; 215.45 mg microcrystalline cellulose; 14.58 mg poly vinyl pyrrolidone K-30; 45.36 mg crospovidone; 0.65 mg poloxamer; 3.24 mg fumed silica; 9.72 mg magnesium stearate; and 19.44 mg seal-coat.
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