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Claims for Patent: 9,265,725

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Claims for Patent: 9,265,725

Title:Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
Abstract: The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
Inventor(s): Tamarkin; Dov (Maccabim, IL), Friedman; Doron (Karmei Yosef, IL), Berman; Tal (Rishon LeZiyyon, IL), Ziv; Enbal (Gedera, IL), Schuz; David (Moshav Gimzu, IL)
Assignee: Foamix Pharmaceuticals Ltd. (Rehovot, IL)
Application Number:11/825,406
Patent Claims: 1. A foamable composition comprising a formable carrier and a propellant, the foamable carrier comprising: a) about 15% by weight of an azelaic acid; b) about 11% by weight of medium-chain triglycerides; c) about 11% by weight of propylene glycol; d) about 5% by weight of dimethyl isosorbide; e) about 3% by weight of PEG-40 stearate; f) about 1% by weight of a cetostearyl alcohol; g) about 1% by weight of polysorbate 80; h) about 0.5% by weight of a monoglyceride, a diglyceride, or a combination; i) about 0.3% by weight of a xanthan gum; j) about 0.1% by weight of methylcellulose; k) about 0.1% by weight of a benzoic acid; l) water; m) sodium hydroxide; and wherein the pH of said foamable carrier is about 4.5-5.3; and wherein the propellant is at a concentration of about 3% to about 25% by weight of the total composition.

2. The foamable composition of claim 1, wherein the medium-chain triglycerides are caprylic/capric triglycerides.

3. The foamable composition of claim 1, wherein the monoglyceride is glyceryl stearate.

4. The foamable composition of claim 1, wherein the medium-chain triglycerides are caprylic/capric triglycerides and the monoglyceride is glyceryl stearate.

5. A foamable carrier comprising: a) about 15% by weight of an azelaic acid; b) about 11% by weight of medium-chain triglycerides; c) about 11% by weight of propylene glycol; d) about 5% by weight of dimethyl isosorbide; c) about 3% by weight of PEG-40 stearate; f) about 1% by weight of a cetostearyl alcohol; g) about 1% by weight of polysorbate 80; h) about 0.5% by weight of a monoglyceride, a diglyceride, or a combination thereof; i) about 0.3% by weight of a xanthan gum; j) about 0.1% by weight of methylcellulose; k) about 0.1% by weight of a benzoic acid; l) water; m) sodium hydroxide; and wherein the pH of said foamable carrier is about 4.5-5.3.

6. The foamable carrier of claim 5, wherein the medium-chain triglycerides are caprylic/capric triglycerides.

7. The foamable carrier of claim 5, wherein the monoglyceride is glyceryl stearate.

8. The foamable carrier of claim 5, wherein the medium-chain triglycerides are caprylic/capric triglycerides and the monoglyceride is glyceryl stearate.
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