.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 9,248,229

« Back to Dashboard

Claims for Patent: 9,248,229

Title:Packaging system for oxygen-sensitive drugs
Abstract: Described herein are pharmaceutical packaging systems which prevent oxidative degradation of morphine, hydromorphone, promethazine and other oxygen-sensitive drugs, such systems including a syringe with an oxygen permeable tip cap, a hermetically sealed oxygen barrier blister packaging with very low permeability to oxygen and comprises ethylene vinyl, and an oxygen absorber.
Inventor(s): Devouassoux; Thomas (Saint Martin D'Heres, FR), Forat; Eric (Lyons, FR), Proctor; James Kenneth (Nashville, NC)
Assignee: Becton, Dickinson France S.A.S. (Le Pont De Claix, FR)
Application Number:14/207,207
Patent Claims: 1. A pharmaceutical packaging system for an injectable oxygen-sensitive drug, the packaging system comprising: (i) a syringe filled under inert conditions with an injectable oxygen-sensitive drug, wherein the syringe has an oxygen permeable tip cap and wherein the oxygen-sensitive drug is one of morphine, hydromorphone, and promethazine; (ii) a hermetically sealed oxygen barrier blister packaging which houses the syringe, wherein the blister packaging comprises a multilayer bottom web comprising ethylene vinyl alcohol (EVOH) and a multilayer top web lid comprising aluminum foil or EVOH; and (iii) an oxygen absorber, wherein the oxygen absorber reduces the oxygen level present from the time of packaging assembly to about zero percent in about one to three days in the blister packaging and in about one to three months in the syringe.

2. The pharmaceutical packaging system of claim 1, wherein the syringe is plastic or glass.

3. The pharmaceutical packaging system of claim 1, wherein the blister packaging is an aluminum-based cold formed blister, or a molded blister.

4. The pharmaceutical packaging system of claim 1, wherein the oxygen absorber is placed inside the blister packaging.

5. The pharmaceutical packaging system of claim 1, wherein the oxygen absorber is a canister.

6. The pharmaceutical packaging system of claim 1, wherein the oxygen absorber has a capacity to absorb about 30 cc oxygen at 1 atm.

7. The pharmaceutical packaging system of claim 1, wherein the oxygen absorber is iron-based.

8. The pharmaceutical packaging system of claim 1, wherein the oxygen absorber reduces the oxygen level in the blister packaging from the time of packaging assembly to about zero percent at about one day.

9. The pharmaceutical packaging system of claim 1, wherein the oxygen absorber reduces the oxygen level in the syringe from the time of packaging assembly to about zero percent at about one month.

10. The pharmaceutical packaging system of claim 1, wherein the oxygen level remains at about zero percent in the syringe and the blister packaging for at least three years.

11. The pharmaceutical packaging system of claim 1, wherein the injectable oxygen-sensitive drug is morphine.

12. The pharmaceutical packaging system of claim 1, wherein the injectable oxygen-sensitive drug is hydromorphone.

13. The pharmaceutical packaging system of claim 1, wherein the injectable oxygen-sensitive drug is promethazine.

14. The pharmaceutical packaging system of claim 1, wherein the blister packaging is a thermoformed blister.

15. A pharmaceutical packaging system for injectable morphine, the packaging system comprising: (i) a syringe filled under inert conditions with morphine, wherein the syringe has an oxygen permeable tip cap, (ii) a hermetically sealed oxygen barrier blister packaging which houses the syringe, wherein the blister packaging comprises a multilayer bottom web comprising ethylene vinyl alcohol (EVOH) and a multilayer top web lid comprising aluminum foil or EVOH; and (iii) an oxygen absorber, wherein the oxygen absorber reduces the oxygen level from the time of packaging assembly to about zero percent in about one to three days in the blister packaging and in about one to three months in the syringe.

16. A pharmaceutical packaging system for injectable hydromorphone, the packaging system comprising: (i) a syringe filled under inert conditions with hydromorphone, wherein the syringe has an oxygen permeable tip cap, (ii) a hermetically sealed oxygen barrier blister packaging which houses the syringe, wherein the blister packaging comprises a multilayer bottom web comprising ethylene vinyl alcohol (EVOH) and a multilayer top web lid comprising aluminum foil or EVOH; and (iii) an oxygen absorber, wherein the oxygen absorber reduces the oxygen level from the time of packaging assembly to about zero percent in about one to three days in the blister packaging and in about one to three months in the syringe.

17. A pharmaceutical packaging system for injectable promethazine, the packaging system comprising: (i) a syringe filled under inert conditions with promethazine, wherein the syringe has an oxygen permeable tip cap, (ii) a hermetically sealed oxygen barrier blister packaging which houses the syringe, wherein the blister packaging comprises a multilayer bottom web comprising ethylene vinyl alcohol (EVOH) and a multilayer top web lid comprising aluminum foil or EVOH; and (iii) an oxygen absorber, wherein the oxygen absorber reduces the oxygen level from the time of packaging assembly to about zero percent in about one to three days in the blister packaging and in about one to three months in the syringe.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc