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Serving 500+ biopharmaceutical companies globally:

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Generated: August 18, 2017

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Title:Method for enhancing the bioavailability of ospemifene
Abstract: This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) ##STR00001## or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
Inventor(s): Anttila; Markku (Turku, FI)
Assignee: QuatRx Pharmaceuticals (Ann Arbor, MI)
Application Number:14/310,822
Patent Claims: 1. A method for enhancing the bioavailability of a therapeutically active compound of the formula (I) ##STR00005## or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to an individual in connection with the intake of food.

2. The method according to claim 1 wherein compound (I) is ospemifene.

3. The method according to claim 1 wherein the compound is administered at a time point which is in the range defined by 1 hour before starting the food intake and 2 hours after starting the food intake.

4. The method according to claim 3 wherein the compound is administered at a time point which is in the range defined to begin at a time point during the food intake and to end 1 hour after the food intake was started.

5. The method according to claim 4 wherein the compound is administered at a time point which is no later than 0.5 hour after starting the food intake.

6. The method according to claim 1 wherein the food is any foodstuff of nutritional value being capable of causing secretion of bile acids.

7. The method according to claim 1 wherein the compound is used for treatment of osteoporosis.

8. The method according to claim 1 wherein the compound is used for treatment of symptoms related to skin atrophy, or to epithelial or mucosal atrophy.

9. The method according to claim 8 wherein the symptoms are urinary symptoms or vaginal symptoms.
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Harvard Business School
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Queensland Health

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