Deeper Knowledge, Faster

  • Uncover prior art in expired and abandoned patents
  • Obtain formulation and manufacturing information
  • Drug patents in 130+ countries
➤ Start Trial

or, See Plans & Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

Express Scripts
US Army

Generated: January 18, 2018

DrugPatentWatch Database Preview

Claims for Patent: 9,233,068

« Back to Dashboard

Summary for Patent: 9,233,068
Title:Controlled release antimicrobial compositions and methods for the treatment of OTIC disorders
Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
Inventor(s): Lichter; Jay (San Diego, CA), Trammel; Andrew M. (Olathe, KS), Piu; Fabrice (San Diego, CA), Ye; Qiang (San Diego, CA), Dellamary; Luis A. (San Marcos, CA), Lebel; Carl (Malibu, CA), Harris; Jeffrey P. (La Jolla, CA)
Application Number:13/645,126
Patent Claims: 1. A sterile aqueous pharmaceutical composition for use in the treatment of an otic disease or condition comprising a thermoreversible gel and a micronized and non-microencapsulated antimicrobial agent, wherein the thermoreversible gel has a gelation temperature between about room temperature and about body temperature; a non-gelation viscosity that allows injection at or about room temperature with a needle having a gauge in the range of 18-31; and a gelation viscosity between about 15,000 cP and about 1,000,000 cP; and wherein the composition provides sustained release of the antimicrobial agent into the ear for a period of at least 5 days.

2. The pharmaceutical composition of claim 1, wherein the thermoreversible gel comprises a copolymer of polyoxyethylene and polyoxypropylene.

3. The composition of claim 2, wherein the copolymer of polyoxyethylene and polyoxypropylene is Poloxamer 407.

4. The composition of claim 1, wherein the composition is free of preservatives.

5. The composition of claim 1, wherein the antimicrobial agent is an antibiotic.

6. The composition of claim 5, wherein the antibiotic is selected from a sulfonamide, a penicillin, a quinolone, a cephalosporin or a macrolide antibiotic.

7. The composition of claim 5, wherein the antibiotic is a sulfonamide selected from afenide, prontosil, sulfacetamide, sulfamethiazole, sulfanilimide, sulfasalazine, sulfisoxazole, trimethoprim, and cotrimoxazole.

8. The composition of claim 5, wherein the antibiotic is a penicillin selected from amoxicillin, ampicillin, azociling, carbenicillin, cloxacillin, dicloxacillin, flucloxacillin, mezlocillin, meticillin, nafcillin, oxacillin, peperacillin, and ticarcillin.

9. The composition of claim 5, wherein the antibiotic is a quinolone selected from ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, nonfloxacin, ofloxacin, trovafloxacin, grepafloxacin, sparfloxacin, AL-15469A, and AL-38905.

10. The composition of claim 5, wherein the antibiotic is a cephalosporin selected from cefaclor, cefamandole, cefotoxin, cefprozil, cefuroxime, cefixime, cefdinir, cefditoren, cefpodoxime, ceftazidime, ceftibuten, ceftizoxime, ceftriaxone, cefepime, and ceftobirprole.

11. The composition of claim 5, wherein the antibiotic is a macrolide antibiotic selected from azithromycin, clarithromycin, dirithromycin, erythromycin, roxithromycin, troleandomycin, telithromycin, and spectinomycin.

12. The composition of claim 1, wherein the antimicrobial agent is an antifungal agent.

13. The composition of claim 12, wherein the antifungal agent is selected from amrolfine, utenafine, naftifine, terbinafine, flucytosine, fluconazole, itraconazole, ketoconazole, posaconazole, ravuconazole, voriconazole, clotrimazole, econazole, miconazole, oxiconazole, sulconazole, terconazole, tioconazole, nikkomycin Z, caspofungin, micafungin, anidulafungin, amphotericin B, liposomal nystastin, pimaricin, griseofulvin, ciclopirox olamine, haloprogin, tolnaftate, undecylenate, and clioquinol.

14. The composition of claim 1, wherein the otic disease or condition is otitis media.

15. The composition of claim 1, wherein the otic disease or condition is otitis media with effusion.

For more information try a trial or see the plans and pricing

Serving leading biopharmaceutical companies globally:

Fish and Richardson
Express Scripts
Daiichi Sankyo

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.