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Serving hundreds of leading biopharmaceutical companies globally:

Federal Trade Commission
Queensland Health
Johnson and Johnson
Argus Health

Generated: June 21, 2018

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Claims for Patent: 9,227,946

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Summary for Patent: 9,227,946
Title:1-[2-(2,4 dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1a activity for the treatment of cognitive impairment
Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT.sub.3 and 5-HT.sub.1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.
Inventor(s): Faldt; Andre (Ishoj, DK), Holm; Rene (Jyllinge, DK), de Diego; Heidi Lopez (Naerum, DK)
Assignee: H. Lundbeck A/S (Copenhagen-Valby, DK)
Application Number:14/242,337
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 9,227,946
Patent Claims: 1. A method of treating a disease selected from the group consisting of affective disorders, depression, major depressive disorder, anxiety, general anxiety disorder, social anxiety disorder, obsessive compulsive disorder, panic disorder, and panic attacks, the method comprising administering a therapeutically effective amount of a hydrobromide salt of Compound I to a patient in need thereof, wherein Compound I is 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine, the hydrobromide salt of Compound I is a crystalline compound characterized by XRPD reflections at 6.89, 9.73, 13.78 and 14.64+/-0.10.degree. 2.theta., and the method alleviates a symptom or complication of the disease or delays the progression of the disease.

2. The method of claim 1, wherein the hydrobromide salt is characterized by an XRPD as shown in FIG. 3.

3. The method of claim 1, wherein the hydrobromide salt has a particle size distribution corresponding to: D98%: 650-680 .mu.m; D50%: 230-250 .mu.m; and D5%: 40-60 .mu.m; D98%: 370-390 .mu.m; d50%: 100-120 .mu.m; and D5%: 5-15 .mu.m; D98%: 100-125 .mu.m; D50%: 15-25 .mu.m; and D5%: 1-3 .mu.m; or D98%: 50-70 .mu.m; D50%: 3-7 .mu.m; and D5%: 0.5-2 .mu.m.

4. The method of claim 1, wherein the disease is major depressive disorder.

5. The method of claim 1, wherein the disease is depression or major depressive disorder.

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Serving hundreds of leading biopharmaceutical companies globally:

Chinese Patent Office
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Daiichi Sankyo

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