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|Title:||Modulators of ATP-binding cassette transporters|
|Abstract:||Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTC"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.|
|Inventor(s):||Ruah; Sara S. Hadida (La Jolla, CA), Hamilton; Matthew (Hackettstown, NJ), Miller; Mark (San Diego, CA), Grootenhuis; Peter D. J. (San Diego, CA), Bear; Brian (Carlsbad, CA), McCartney; Jason (Cardiff by the Sea, CA), Zhou; Jinglan (San Diego, CA)|
|Assignee:||Vertex Pharmaceuticals Incorporated (Boston, MA)|
|Patent Claims:||1. A pharmaceutical composition comprising: (i) a compound of the formula: ##STR00523## and/or a pharmaceutically acceptable salt thereof; (ii) a pharmaceutically acceptable carrier; and (iii) a compound of the formula: ##STR00524## and/or a pharmaceutically acceptable salt thereof.|
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