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Generated: September 22, 2017

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Title:Treatment of gout and hyperuricemia
Abstract: Sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylt- hio)acetate is described. In addition, pharmaceutical compositions and uses of such compositions for the treatment of a variety of diseases and conditions are described.
Inventor(s): Miner; Jeffrey (San Diego, CA), Girardet; Jean-Luc (San Diego, CA), Quart; Barry D. (Encinitas, CA)
Assignee: ARDEA BIOSCIENCES, INC. (San Diego, CA)
Application Number:13/704,192
Patent Claims: 1. A method of reducing serum uric acid levels, treating hyperuricemia, or treating gout in a human comprising co-administration of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)ace- tate, or a pharmaceutically acceptable salt thereof, and allopurinol to the human, wherein said method provides serum urate levels of less than 6 mg/dL; and wherein said method results in an adverse event in less than 15% of the humans.

2. A method of reducing serum uric acid levels, treating hyperuricemia, or treating gout in a human comprising co-administration of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)ace- tate, or a pharmaceutically acceptable salt thereof, and allopurinol to the human, wherein the serum urate levels are less than 4 mg/dL.

3. A method of reducing serum uric acid levels, treating hyperuricemia, or treating gout in a human comprising co-administration of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)ace- tate, or a pharmaceutically acceptable salt thereof, and allopurinol to the human, wherein said method provides serum urate levels of less than 6 mg/dL; and wherein the method provides a serum urate levels intraday change from baseline of more than 50%.

4. A method of reducing serum uric acid levels, treating hyperuricemia, or treating gout in a human comprising co-administration of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)ace- tate, or a pharmaceutically acceptable salt thereof, and allopurinol to the human, wherein said method provides serum urate levels of less than 6 mg/dL, wherein the gout in the human is characterized by the presence of large accumulated deposits of uric acid or tophi.
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