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Claims for Patent: 9,205,059

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Claims for Patent: 9,205,059

Title:Transparent transdermal nicotine delivery devices
Abstract: A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%.
Inventor(s): Gale; Robert M. (Los Altos, CA)
Assignee: ALZA Corporation (Vacaville, CA)
Application Number:14/629,248
Patent Claims: 1. A device for transdermal administration of nicotine, comprising: a backing layer comprising a material selected from the group consisting of PET/EVA laminates, HDPE/EAA/nylon/EAA multilaminate, and a film comprising a graft copolymer formed from about 73-77% acrylonitrile and from about 23-27% methyl acrylate copolymerized in the presence of about 8-10 parts by weight of butadiene/acrylonitrile copolymers, and a drug reservoir layer carried by the backing layer, wherein the drug reservoir layer comprises nicotine, and wherein the device exhibits an Opacity Index of less than 48.6% to permit the skin to which the device is applied to be visible through the device.

2. The device of claim 1, wherein the drug reservoir layer further comprises a self-adhesive drug reservoir.

3. The device of claim 1, wherein the drug reservoir layer further comprises one or more adhesives.

4. The device of claim 3, wherein the one or more adhesives comprises one or more pressure sensitive adhesives selected from the group consisting of polysiloxanes, polyacrylates, polyurethanes, acrylic adhesives, vinyl acetate adhesives, ethylene vinyl acetate copolymers, natural or synthetic rubbers, and mixtures and graft copolymers thereof.

5. The device of claim 1, wherein the device is provided with one or more hydrophilic water absorbing polymers.

6. The device of claim 1, wherein the backing has a nicotine permeability of less than 1.0 .mu.g/cm.sup.2/hr.

7. The device of claim 1, wherein the backing has a nicotine permeability of less than 0.5 .mu.g/cm.sup.2/hr.

8. The device of claim 1, wherein the backing has a solubility for nicotine of less than 1 wt %.

9. The device of claim 1, wherein the backing has a solubility for nicotine of less than 0.1 wt %.

10. The device of claim 1, wherein the device has an Opacity Index of less than 35.11%.

11. The device of claim 1, wherein the device has an Opacity Index of less than 20%.

12. The device of claim 1, wherein the backing comprises a PET/EVA laminate.

13. The device of claim 1, wherein the backing comprises a HDPE/EAA/nylon/EAA multilaminate.

14. The device of claim 1, wherein the backing comprises a film comprising a graft copolymer formed from about 73-77% acrylonitrile and from about 23-27% methyl acrylate copolymerized in the presence of about 8-10 parts by weight of butadiene/acrylonitrile copolymers containing approximately 70% by weight of polymer units derived from butadiene.

15. The device of claim 1, wherein the device provides delivery of nicotine for a period of 18-24 hours.

16. The device of claim 1, wherein the device further comprises an adhesive for maintaining the device on the skin of a subject.
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