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Claims for Patent: 9,186,346

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Claims for Patent: 9,186,346

Title:Methods for reducing the risk of an adverse teriflunomide and rosuvastatin interaction in multiple sclerosis patients
Abstract: This invention relates to a method for managing the risk of an adverse interaction between teriflunomide and a substrate of breast cancer resistance protein (BCRP) and/or organic anion transporting polypeptide B1 and B3 (OATP1B1/B3).
Inventor(s): Weitz; Dietmar (Konigstein im Taunus, DE), Menguy-Vacheron; Francoise (Paris, FR), Clot; Pierre-Francois (Epinay sur Orge, FR), Turpault; Sandrine (Pennington, NJ)
Assignee: SANOFI (Paris, FR)
Application Number:14/172,082
Patent Claims: 1. A method for treating multiple sclerosis while managing the risk of teriflunomide and rosuvastatin interaction in a patient having multiple sclerosis, wherein rosuvastatin is co-administered with teriflunomide, comprising administering to the patient about 7 or 14 mg of teriflunomide daily, and administering to the patient rosuvastatin which is at the amount of about 50% of the normal dose of rosuvastatin.

2. The method according to claim 1, wherein the patient has relapsing forms of multiple sclerosis.

3. The method according to claim 1, wherein rosuvastatin is co-administered with teriflunomide at the same time.

4. The method according to claim 2, wherein rosuvastatin is co-administered with teriflunomide at the same time.

5. A method for treating multiple sclerosis while managing the risk of teriflunomide and rosuvastatin interaction in a patient having multiple sclerosis, wherein rosuvastatin is co-administered with teriflunomide, comprising administering to the patient about 7 or 14 mg of teriflunomide daily, and administering to the patient rosuvastatin at a dose that does not exceed 10 mg once daily.

6. The method according to claim 5, wherein the patient has relapsing forms of multiple sclerosis.

7. The method according to claim 5, wherein rosuvastatin is co-administered with teriflunomide at the same time.

8. The method according to claim 6, wherein rosuvastatin is co-administered with teriflunomide at the same time.
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