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Serving leading biopharmaceutical companies globally:

McKesson
Johnson and Johnson
Moodys
QuintilesIMS
Deloitte
US Department of Justice
Baxter
AstraZeneca
Chinese Patent Office
Queensland Health

Generated: December 13, 2017

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Claims for Patent: 9,169,238

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Claims for Patent: 9,169,238

Title:Solid pharmaceutical composition
Abstract: The present invention relates to a solid preparation containing a compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof, a pH control agent and a diuretic, which is superior in the stability and dissolution property of the compound represented by the formula (I) and the diuretic. ##STR00001##
Inventor(s): Tanoue; Yutaka (Osaka, JP), Nomura; Junya (Osaka, JP)
Assignee: Takeda Pharmaceutical Company Limited (Osaka, JP)
Application Number:12/737,612
Patent Claims: 1. A solid preparation comprising a first part comprising a compound which is (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]met- hyl}-1H-benzimidazole-7-carboxylate potassium salt and a pH control agent and a second part comprising chlorthalidone, which is obtained by granulating separately from the first part, wherein a pH of a solution or suspension obtained by dissolving or suspending the pH control agent in water at 25.degree. C. at a concentration of 1 w/v % is 2 to 5.

2. The solid preparation of claim 1, wherein the pH control agent is an acidic substance selected from the group consisting of tartaric acid, citric acid, lactic acid, fumaric acid, succinic acid, phosphoric acid, malic acid, ascorbic acid, acetic acid and acidic amino acid, or a salt thereof, or a solvate thereof.

3. The solid preparation of claim 1, wherein the pH control agent is monosodium fumarate, or a combination of fumaric acid and sodium ion donor.

4. The solid preparation of claim 1, which is a single layer tablet obtained by mixing the first part and the second part to give a mixture, and compressing the mixture.

5. The solid preparation of claim 1, which is a multi-layer tablet comprising a first layer comprised of the first part and a second layer comprised of the second part.

6. The solid preparation of claim 1, wherein the pH control agent is in a proportion of 0.01-20 wt % of the preparation.

7. A method of stabilizing a compound which is (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]met- hyl}-1H-benzimidazole-7-carboxylate potassium salt and chlorthalidone in a solid preparation, which method comprises separately granulating a first part comprising the compound and a pH control agent and a second part comprising chlorthalidone to give the solid preparation comprising the first part and the second part, wherein a pH of a solution or suspension obtained by dissolving or suspending the pH control agent in water at 25.degree. C. at a concentration of 1 w/v % is 2 to 5.

8. A method of improving dissolution property of a compound which is (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]met- hyl}-1H-benzimidazole-7-carboxylate potassium salt from a solid preparation comprising the compound and chlorthalidone, which method comprises separately granulating a first part comprising the compound and a pH control agent and a second part comprising chlorthalidone to give the solid preparation comprising the first part and the second part, wherein a pH of a solution or suspension obtained by dissolving or suspending the pH control agent in water at 25.degree. C. at a concentration of 1 w/v % is 2 to 5.
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Serving leading biopharmaceutical companies globally:

Medtronic
McKesson
Argus Health
Healthtrust
Farmers Insurance
Daiichi Sankyo
Fuji
Moodys
Baxter
Federal Trade Commission

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