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Last Updated: December 16, 2025

Claims for Patent: 9,127,276

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Summary for Patent: 9,127,276

Title:	Conjugated antisense compounds and their use
Abstract:	Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine.
Inventor(s):	Thazha P. Prakash, Punit P. Seth, Eric E. Swayze
Assignee:	Ionis Pharmaceuticals Inc
Application Number:	US14/267,842
Patent Claims:	1. A compound having the formula (XXVI): wherein: T2 is a group comprising a nucleoside, a nucleotide, a monomeric subunit, a reactive ester, a linker, a cleavable moiety or an oligomeric compound. 2. The compound of claim 1, wherein the linker comprises an amine, an amide, an ester, an ether, a pyrrolidine, PEG, a polyamide, or a disulfide bond. 3. The compound of claim 1, wherein the linker does not comprise a pyrrolidine. 4. The compound of claim 1, wherein the linker has the formula: 5. The compound of claim 1, wherein T2 has the formula: wherein: CM is a cleavable moiety and T3 is a nucleoside, a nucleotide, a monomeric subunit, or an oligomeric compound. 6. The compound of claim 1, wherein T2 has the formula: wherein: T3 is a nucleoside, a nucleotide, a monomeric subunit, or an oligomeric compound.

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