Claims for Patent: 9,126,947

Summary for Patent: 9,126,947

Title:	Substituted pyridazine carboxamide compounds
Abstract:	The new pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases especially against ALK and are useful in treating disorders related to abnormal protein kinase activities such as cancer, neurological and psychiatric diseases.
Inventor(s):	Congxin Liang
Assignee:	Xcovery Holdings Inc
Application Number:	US13/877,783
Patent Claims:	1. A compound of formula III: or a salt thereof; or a prodrug, or a salt of a prodrug thereof; or a hydrate, solvate, or polymorph thereof; wherein; n is 0-2; R5 and R11 each are independently H, alkyl or Z1; R9 is alkyl or Z1; R10 is H, alkyl, or Z1; each Z1 is independently halogen, CN, NO2, OR15, SR15, S(O)2OR15, NR15R16, C1-C2 perfluoroalkyl, C1-C2 perfluoroalkoxy, 1,2-methylenedioxy, C(O)OR15, C(O)NR15R16, OC(O)NR15R16, NR15C(O)NR15R16, C(NR16)NR15R16, NR15C(NR16)NR15R16, S(O)2NR15R16, R17, C(O)R17, NR15C(O)R17, S(O)R17, S(O)2R17, R16, OXO, C(O)R16, C(O)(CH2)mOH, (CH2)mOR15, (CH2)mC(O)NR15R16, NR15S(O)2R17, where each m is independently 0-6; Each R15 is independently hydrogen, C1-C4 alkyl or C3-C6 cycloalkyl; Each R16 is independently hydrogen, alkenyl, alkynyl, C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or C1-C4 alkyl substituted with C3-C6 cycloalkyl, aryl, heterocyclyl or heteroaryl; and Each R17 is independently C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or C1-C4 alkyl substituted with C3-C6 cycloalkyl, aryl, heterocyclyl or heteroaryl. 2. The compound of claim 1, wherein R11 is hydrogen. 3. A compound of claim 1 wherein the compound is: N-{4-[((3S,5R)-3,5-dimethylpiperazinyl)carbonyl]phenyl}{6-amino-5-[(2,6-dichloro-3-fluorophenyl)ethoxy]pyridazin-3-yl}carboxamide. 4. The compound of claim 1, wherein the compound is selected from the following: {5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-aminopyridazin-3-yl}-N-{4-[(3-oxopiperazinyl)carbonyl]phenyl}carboxamide; {5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-aminopyridazin-3-yl}-N-{4-[(3,3-dimethylpiperazinyl)carbonyl]phenyl}carboxamide; and {5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-aminopyridazin-3-yl}-N-{4-[((3S,5R)-3,5-dimethylpiperazinyl)carbonyl]phenyl}carboxamide. 5. A composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.