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Claims for Patent: 9,126,931

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Claims for Patent: 9,126,931

Title:Tetracyclic compound
Abstract: A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: ##STR00001## (meanings of the symbols that are included in the formula are as given in the specification).
Inventor(s): Kinoshita; Kazutomo (Kanagawa, JP), Asoh; Kohsuke (Kanagawa, JP), Furuichi; Noriyuki (Kanagawa, JP), Ito; Toshiya (Kanagawa, JP), Kawada; Hatsuo (Kanagawa, JP), Ishii; Nobuya (Kanagawa, JP), Sakamoto; Hiroshi (Kanagawa, JP), Hong; WooSang (Gyeonggi-do, KR), Park; MinJeong (Gyeonggi-do, KR), Ono; Yoshiyuki (Shizuoka, JP), Kato; Yasuharu (Shizuoka, JP), Morikami; Kenji (Shizuoka, JP), Emura; Takashi (Shizuoka, JP), Oikawa; Nobuhiro (Kanagawa, JP)
Assignee: Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)
Application Number:13/377,300
Patent Claims: 1. A compound or salt or solvate thereof represented by Formula (I): ##STR01235## wherein, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.7, A.sup.8, A.sup.9 and A.sup.10 all represent C; A.sup.5 is selected from NR.sup.5, O and S; R.sup.1 and R.sup.10 each independently represent [1] a hydrogen atom, [2] a cyano group, [3] a halogen atom or [4] a 4- to 10-membered heterocycloalkyl group which may be substituted by 4- to 10-membered heterocycloalkyl group(s); R.sup.2 is selected from the group consisting of: (1) a hydrogen atom, (2) a C.sub.1-8 alkyl group, (3) a C.sub.2-8 alkenyl group, (4) a C.sub.2-8 alkynyl group, (5) a cyano group, (6) a halogen atom, (7) a (C.sub.1-8 alkyl)-amino group which may be substituted by C.sub.1-8 alkylsulfonyl group(s), m2: 0.about.2, and (8) a nitro group; R.sup.3 is selected from the group consisting of: (1) a hydrogen atom, (2) a C.sub.1-8 alkyl group which may be substituted by [1] halogen atom(s), [2] hydroxy group(s) or [3] C.sub.1-8 alkoxy group(s), (3) a C.sub.6-10 aryl group, (4) a cyano group, (5) a C.sub.1-8 alkanoyl group which may be substituted by C.sub.6-10 aryl group(s), (6) a (C.sub.1-8 alkyl).sub.m3a-aminocarbonyl group which may be substituted by one or more R.sup.3A, R.sup.3A: [1] a C.sub.6-10 aryl group, [2] a C.sub.1-8 alkoxy group, [3] a 5- to 14-membered heteroaryl group, or [4] a C.sub.6-10 arylsulfonyl group, m3a: 0.about.2, (7) a hydroxycarbonyl group, (8) a C.sub.1-8 alkoxycarbonyl group which may be substituted by [1] hydroxy group(s) or [2] C.sub.1-8 alkoxy group(s), (9) a halogen atom, (10) a (C.sub.1-8 alkyl).sub.m3b-amino group which may be substituted by C.sub.6-10 aryl group(s), m3b: 0.about.2, (11) a C.sub.1-8 alkylcarbonyl (C.sub.0-8 alkyl)amino group which may be substituted by [1] C.sub.6-10 aryl group(s) or [2] C.sub.6-10 aryloxy group(s), (12) a C.sub.6-10 arylcarbonyl (C.sub.0-8 alkyl)amino group which may be substituted by C.sub.1-8 alkyl group(s) which may be substituted by halogen atom(s), (13) a (C.sub.1-8 alkyl).sub.m3c-aminocarbonyl (C.sub.0-8 alkyl)amino group which may be substituted by C.sub.6-10 aryl group(s), m3c: 0.about.2, (14) a nitro group, (15) a hydroxy group, (16) a C.sub.1-8 alkoxy group which may be substituted by one or more R.sup.3B, R.sup.3B: [1] a hydroxy group, [2] a C.sub.1-8 alkoxy group, [3] a C.sub.6-10 aryl (C.sub.0-8 alkyl)aminocarbonyl group, [4] a (C.sub.1-8 alkyl).sub.m3d-amino group, or [5] a halogen atom, m3 d: 0.about.2, (17) a 4- to 10-membered heterocycloalkyloxy group, (18) a 5- to 14-membered heteroaryloxy group, (19) a (C.sub.1-8 alkyl).sub.m3e-aminocarbonyloxy group which may be substituted by C.sub.6-10 aryl group(s) m3e: 0.about.2, (20) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group, (21) a C.sub.1-8 alkylsulfonyloxy group which may be substituted by halogen atom(s), (22) a C.sub.1-8 alkylthio group, (23) a C.sub.1-8 alkylsulfonyl group which may be substituted by C.sub.6-10 aryl group(s), (24) a 5- to 14-membered heteroaryl group which may be substituted by C.sub.1-8 alkyl group(s) which may be substituted by C.sub.1-8 alkoxy group(s), (25) a C.sub.1-8 alkoxycarbonyl (C.sub.0-8 alkyl)amino group which may be substituted by C.sub.1-8 alkoxy group(s), (26) a C.sub.6-10 aryloxycarbonyl (C.sub.0-8 alkyl)amino group which may be substituted by C.sub.1-8 alkyl group(s) which may be substituted by halogen atom(s), (27) a C.sub.6-10 aryl (C.sub.0-8 alkyl)aminocarbonyl (C.sub.0-8 alkyl)amino group which may be substituted by one or more R.sup.3C, R.sup.3C: [1] a C.sub.1-8 alkyl group which may be substituted by halogen atom(s), or [2] a C.sub.1-8 alkoxy group, (28) a C.sub.3-8 cycloalkyl (C.sub.0-8 alkyl)aminocarbonyloxy group, and (29) a C.sub.6-10 aryl (C.sub.0-8 alkyl)aminocarbonyloxy group which may be substituted by substituent(s) selected from the group consisting of [1] a C.sub.1-8 alkyl group and [2] a C.sub.1-8 alkoxy group; R.sup.4 is selected from the group consisting of: (1) a hydrogen atom, (2) a C.sub.1-8 alkyl group which may be substituted by halogen atom(s), (3) a C.sub.2-8 alkenyl group, (4) a C.sub.2-8 alkynyl group, (5) a C.sub.3-8 cycloalkyl group, (6) a cyano group, (7) an aminocarbonyl group, (8) a (C.sub.1-8 alkyl).sub.m4a-aminocarbonyl group, m4a: 1.about.2, (9) a hydroxycarbonyl group, (10) a C.sub.1-8 alkoxycarbonyl group, (11) a halogen atom, (12) a (C.sub.1-8 alkyl).sub.m4b-amino group, m4b: 0.about.2, (13) a hydroxy group, and (14) a C.sub.1-8 alkoxy group which may be substituted by hydroxy group(s); R.sup.5 is selected from the group consisting of: (1) a hydrogen atom, (2) a C.sub.1-8 alkyl group which may be substituted by one or more R.sup.5A, R.sup.5A: [1] a hydroxycarbonyl group, [2] a C.sub.1-8 alkoxycarbonyl group, [3] a hydroxy group, [4] a C.sub.1-8 alkoxy group, [5] a (C.sub.1-8 alkyl).sub.m5-amino group, [6] a C.sub.6-10 aryl group, or [7] a C.sub.1-8 alkylthio group, m5: 0.about.2, (3) a C.sub.2-8 alkenyl group, (4) a C.sub.2-8 alkynyl group, (5) a C.sub.3-8 cycloalkyl group, and (6) a C.sub.1-8 alkylsulfonyl group; R.sup.6 and R.sup.6' are each independently selected from the group consisting of: (1) a C.sub.1-8 alkyl group which may be substituted by halogen atom(s), (2) a C.sub.2-8 alkenyl group, and (3) a C.sub.2-8 alkynyl group; or R.sup.6 and R.sup.6' are taken together with the carbon atoms to which they are bound to form: (4) a C.sub.3-8 cycloalkyl group, or (5) a 4- to 10-membered heterocycloalkyl group which may be substituted by C.sub.1-8 alkyl C.sub.6-10 aryl sulfonyl group(s) which may be substituted by C.sub.1-8 alkyl group(s); R.sup.7 is selected from the group consisting of: (1) a hydrogen atom, (2) a halogen atom, (3) a C.sub.1-8 alkoxy group which may be substituted by one or more R.sup.7A, R.sup.7A: [1] a (C.sub.1-8 alkyl).sub.m7a-amino group, [2] a hydroxy, [3] a 4- to 10-membered heterocycloalkyl group which may be substituted by C.sub.1-8 alkyl group(s), m7a: 0.about.2, (4) a C.sub.1-8 alkylsulfonyl group, (5) a nitro group, and (6) a hydroxyl group; R.sup.8 is selected from the group consisting of: (1) a hydrogen atom, (2) a C.sub.1-8 alkyl group which may be substituted by one or more R.sup.8A, R.sup.8A: [1] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.8A1, [2] a (C.sub.1-8 alkyl).sub.m8a-amino group which may be substituted by a halogen atom, or [3] a hydroxy group, m8a:0.about.2, R.sup.8A1: [1] a C.sub.1-8 alkyl group, [2] a C.sub.1-8 alkylsulfonyl group, [3] a (C.sub.1-8 alkyl).sub.m8b-aminosulfonyl group, [4] an oxo group, [5] a C.sub.1-8 alkoxycarbonyl, or [6] a C.sub.1-8 alkoxycarbonyl (C.sub.0-8 alkyl)aminosulfonyl, m8b: 0.about.2, (3) a C.sub.2-8 alkenyl group, (4) a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.8B, R.sup.8B: <1> a C.sub.1-8 alkyl group which may be substituted by one or more R.sup.8B1, <2> a C.sub.2-8 alkeynyl group, <3> a C.sub.2-8 alkynyl group, <4> a C.sub.3-8 cycloalkyl group which may be substituted by [1] cyano group(s) or [2] C.sub.1-8 alkyl group(s), <5> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.8B2, <6> a C.sub.1-8 alkoxy group which may be substituted by substituent(s) selected from the group consisting of [1] a C.sub.1-8 alkoxy group and [2] a C.sub.3-8 cycloalkyl group, <7> a C.sub.1-8 alkoxycarbonyl group, <8> a C.sub.1-8 alkylsulfonyl group, <9> a 5- to 14-membered heteroarylsulfonyl group, <10> an oxo group, <11> a cyano group, <12> a C.sub.1-8 alkanoyl group which may be substituted by one or more R.sup.8B3, <13> a C.sub.3-8 cycloalkylcarbonyl group, <14> a (C.sub.1-8 alkyl).sub.m8c-aminosulfonyl group, <15> a C.sub.1-8 alkylsulfonyl (C.sub.0-8 alkyl)amino group, <16> a (C.sub.1-8 alkyl).sub.m8d-amino group which may be substituted by one or more R.sup.8B4, <17> a hydroxy group, <18> a (C.sub.1-8 alkyl).sub.m8e-aminocarbonyl group, or <19> a C.sub.1-8 alkoxycarbonyl (C.sub.0-8 alkyl)amino group m8c: 0.about.2 m8d: 0.about.2 m8e: 0.about.2 R.sup.8B1: [1] a C.sub.3-8 cycloalkyl group, [2] a hydroxy group, or [3] a C.sub.1-8 alkoxy group(s), R.sup.8B2: [1] a halogen atom, [2] a C.sub.1-8 alkyl group, [3] an oxo group, [4] a hydroxy group, or [5] a deuterium atom, R.sup.8B3: a (C.sub.1-8 alkyl).sub.m8f-amino group, m8f: 0.about.2, R.sup.8B4: [1] a C.sub.3-8 cycloalkyl group, or [2] a hydroxy group, (5) a 5- to 14-membered heteroaryl group which may be substituted by a C.sub.1-8 alkyl group, (6) a (C.sub.1-8 alkyl).sub.m8g-aminocarbonyl group which may be substituted by one or more R.sup.8C, m8g: 0.about.2, R.sup.8C: [1] a hydroxy group, [2] a (C.sub.1-8 alkyl).sub.m8h-amino group which may be substituted by substituent(s) selected from the group consisting of <1> a (C.sub.1-8 alkyl).sub.m8i-aminosulfonyl group, <2> a C.sub.1-8 alkylsulfonyl group, <3> a C.sub.1-8 alkoxycarbonyl group and <4> a C.sub.1-8 alkoxycarbonyl(C.sub.0-8 alkyl)aminosulfonyl group, [3] a C.sub.1-8 alkylsulfonyl group, or [4] a C.sub.1-8 alkoxy group which may be substituted by a hydroxy group, m8h: 0.about.2, m8i: 0.about.2, (7) a 4- to 10-membered heterocycloalkyl (C.sub.0-8 alkyl)aminocarbonyl group which may be substituted by oxo group(s), (8) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by one or more R.sup.8D, R.sup.8D: [1] a C.sub.1-8 alkyl group which may be substituted by one or more R.sup.8D1, [2] a hydroxy group, [3] a C.sub.1-8 alkylsulfonyl group, or [4] a C.sub.1-8 alkoxycarbonyl group, R.sup.8D1: [1] a hydroxy group, or [2] a C.sub.1-8 alkoxy group, (9) a hydroxycarbonyl group, (10) a C.sub.0-8 alkoxy (C.sub.0-8 alkyl)aminocarbonyl group which may be substituted by hydroxy group(s), (11) a halogen atom, (12) a (C.sub.1-8 alkyl).sub.m8j-amino group which may be substituted by one or more R.sup.8H, m8j: 0.about.2, R.sup.8H: [1] a hydroxy group, or [2] a 4- to 10-membered heterocycloalkyl group, (13) a hydroxyl group, (14) a C.sub.1-8 alkoxy group which may be substituted by one or more R.sup.8E, R.sup.8E: <1> a hydroxy group, <2> halogen atom, <3> a hydroxycarbonyl group, <4> a C.sub.1-8 alkoxycarbonyl group, <5> a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by one or more R.sup.8E1, <6> a (C.sub.1-8 alkyl).sub.m8k1-amino group which may be substituted by one or more R.sup.8E2, m8k1: 0.about.2, <7> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.8E3, <8> a 5- to 14-membered heteroaryl group, <9> a (C.sub.1-8 alkyl).sub.m8k2-aminocarbonyl group which may be substituted by one or more R.sup.8E6, m8k2: 0.about.2, <10> a C.sub.1-8 alkoxy group which may be substituted by one or more R.sup.8E7, <11> a C.sub.1-8 alkylthio group, <12> a C.sub.1-8 alkylsulfinyl group, <13> a C.sub.1-8 alkylsulfonyl group, R.sup.8E1: <1> a C.sub.1-8 alkoxycarbonyl group, <2> a C.sub.1-8 alkanoyl group, <3> a C.sub.1-8 alkylsulfonyl group, <4> a (C.sub.1-8 alkyl).sub.m8k3-aminosulfonyl group, m8k3: 0.about.2, or <5> a 4- to 10-membered heterocycloalkyl group, R.sup.8E2: <1> a hydroxy group, <2> a C.sub.1-8 alkoxycarbonyl group which may be substituted by halogen atom(s), <3> a C.sub.3-8 cycloalkyl group which may be substituted by C.sub.1-8 alkyl group(s) which may be substituted by hydroxy group(s), <4> a C.sub.1-8 alkanoyl group which may be substituted by substituent(s) selected from the group consisting of [1] a (C.sub.1-8 alkyl).sub.m8k4-amino group and [2] a halogen atom(s), m8k4: 0.about.2, <5> a (C.sub.1-8 alkyl).sub.m8k5-aminocarbonyl group, m8k5: 0.about.2, <6> a C.sub.1-8 alkylsulfonyl group, <7> a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyl group which may be substituted by C.sub.1-8 alkyl group(s), <8> a (C.sub.1-8 alkyl).sub.m8k6-aminosulfonyl group which may be substituted by C.sub.1-8 alkoxycarbonyl group(s), m8k6: 0.about.2, or R.sup.8E3: <1> a C.sub.1-8 alkyl group which may be substituted by substituent(s) selected from the group consisting of [1] a hydroxy group and [2] a C.sub.1-8 alkylcarbonyloxy group, <2> a C.sub.1-8 alkylcarbonyloxy group, <3> a hydroxy group, <4> a C.sub.3-8 cycloalkyl group, <5> a C.sub.1-8 alkoxy group, <6> a C.sub.1-8 alkoxycarbonyl group, <7> a C.sub.1-8 alkylsulfonyl group, <8> a (C.sub.1-8 alkyl).sub.m8k8-aminocarbonyl group m8k8: 0.about.2, <9> a C.sub.1-8 alkanoyl group which may be substituted by hydroxy group(s), <10> an oxo group, or <11> a 4- to 10-membered heterocycloalkyl group which may be substituted by substituent(s) selected from the group consisting of [1] a C.sub.1-8 alkanoyl group, [2] a C.sub.1-8 alkoxycarbonyl group and [3] a C.sub.1-8 alkylsulfonyl group, R.sup.8E6: <1> a C.sub.2-8 alkenylcarbonyloxy group, <2> a hydroxy group, <3> a cyano group, <4> a (C.sub.1-8 alkyl).sub.m8k9-amino group which may be substituted by hydroxy group(s) m8k9: 0.about.2, <5> a C.sub.1-8 alkoxy group which may be substituted by hydroxy group(s), <6> a C.sub.1-8 alkylcarbonyloxy group, <7> a 4- to 10-membered heterocycloalkyl group which may be substituted by C.sub.1-8 alkyl group(s), or <8> a 5- to 14-membered heteroaryl group, R.sup.8E7: <1> a hydroxy group, or <2> a C.sub.1-8 alkoxy group which may be substituted by hydroxy group(s), (15) a 4- to 10-membered heterocycloalkyloxy group which may be substituted by one or more R.sup.8F, R.sup.8F: <1> a C.sub.1-8 alkyl group which may be substituted by one or more R.sup.8F1, <2> a C.sub.3-8cycloalkyl group, <3> a C.sub.1-8 alkanoyl group which may be substituted by halogen atom(s), <4> a C.sub.1-8 alkylcarbonyloxy group, <5> a C.sub.1-8 alkoxycarbonyl group, <6> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.8F2, <7> a C.sub.1-8 alkyl sulfonyl group, <8> a hydroxy group, or [9] a C.sub.6-10 aryl group, R.sup.8F1: [1] a hydroxy group, [2] a C.sub.1-8 alkoxy group, or [3] a halogen atom, R.sup.8F2: [1] a 4- to 10-membered heterocycloalkyl group, [2] a C.sub.1-8 alkoxycarbonyl group, or [3] a C.sub.1-8 alkylsulfonyl group, (16) a 5- to 14-membered heteroaryloxy group, (17) a 4- to 10-membered heterocycloalkylcarbonyloxy group, (18) a (C.sub.1-8 alkyl).sub.m8l1-aminosulfonyloxy group, m8l1: 0.about.2, (19) a C.sub.1-8 alkyl thio group which may be substituted by [1] (C.sub.1-8 alkyl).sub.m8l2-amino group(s), [2] hydroxy group(s) or [3] hydroxycarbonyl group(s), m8l2: 0.about.2, (20) a C.sub.1-8 alkylsulfonyl group which may be substituted by one or more R.sup.8G, R.sup.8G: [1] a hydroxycarbonyl group, [2] a hydroxy group, or [3] a (C.sub.1-8 alkyl).sub.m8l3-amino group, m8l3: 0.about.2, (21) a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyloxy group which may be substituted by C.sub.1-8 alkyl group(s), (22) a C.sub.2-8 alkenyloxy group, and (23) a C.sub.1-8 alkylsulfonyloxy group which may be substituted by halogen atom(s); R.sup.9 is selected from the group consisting of: (1) a hydrogen atom, (2) a C.sub.1-8 alkyl group which may be substituted by one or more R.sup.9A, R.sup.9A: [1] a C.sub.3-8 cycloalkyl group, [2] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.9A1, [3] a hydroxy group, [4] a C.sub.1-8 alkoxy group, or [5] a hydroxycarbonyl group, R.sup.9A1: [1] a C.sub.1-8 alkyl group, [2] a C.sub.3-8 cycloalkyl group, or [3] a 4- to 10-membered heterocycloalkyl group, (3) a C.sub.2-8 alkenyl group which may be substituted by one or more R.sup.9B, R.sup.9B: [1] a (C.sub.1-8 alkyl).sub.m9a-amino group, [2] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more group R.sup.9B1, R.sup.9B1: [1] a C.sub.3-8 cycloalkyl group, or [2] a 4- to 10-membered heterocycloalkyl group, m9a: 0.about.2, (4) a C.sub.2-8 alkynyl group which may be substituted by one or more R.sup.9C, R.sup.9C: [1] a C.sub.1-8 alkoxy group, [2] a (C.sub.1-8 alkyl).sub.m9b-amino group which may be substituted by C.sub.6-10 aryl group(s), [3] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.9C1, [4] a C.sub.3-8 cycloalkyl group, [5] a hydroxy group, [6] a hydroxycarbonyl group, or [7] a C.sub.1-8 alkyloxycarbonyl group, m9b: 0.about.2, R.sup.9C1: [1] a C.sub.3-8 cycloalkyl group, [2] a 4- to 10-membered heterocycloalkyl group, or [3] an oxo group, (5) a C.sub.3-8 cycloalkyl group, (6) a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.9D, R.sup.9D: [1] a C.sub.1-8 alkyl group which may be substituted by 4- to 10-membered heterocycloalkyl group(s), [2] a C.sub.3-8 cycloalkyl group, [3] a 4- to 10-membered heterocycloalkyl group, or [4] a C.sub.1-6 alkylsulfonyl group, or [5] a C.sub.1-8 alkoxycarbonyl group, (7) a C.sub.6-10 aryl group which may be substituted by one or more R.sup.9E, R.sup.9E: [1] a halogen atom, [2] a hydroxy group, [3] a hydroxycarbonyl group, or [4] a

C.sub.1-8 alkyl group which may be substituted by hydroxy group(s), or [5] a C.sub.1-8 alkoxy group, (8) a 5- to 14-membered heteroaryl group which may be substituted by C.sub.1-8 alkyl group(s), (9) a cyano group, (10) a C.sub.1-8 alkanoyl group, (11) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by C.sub.1-8 alkyl group(s), (12) a halogen atom, (13) a (C.sub.1-8 alkyl).sub.m9c-amino group which may be substituted by one or more R.sup.9F, R.sup.9F: [9F-1] a C.sub.1-3 alkylsulfonyl group, [9F-2] a (C.sub.1-3 alkyl).sub.m9f1-aminosulfonyl group (m9f1: 0.about.2), or [9F-3] a C.sub.1-3 alkanoyl group which may be substituted by (C.sub.1-3 alkyl).sub.m9f2-amino group(s) (m9f2: 0.about.2), m9c: 0.about.2 (14) a C.sub.1-8 alkylcarbonyl(C.sub.0-8 alkyl)amino group which may be substituted by (C.sub.1-8 alkyl).sub.m9d-amino group(s), m9d: 0.about.2, (15) a C.sub.1-8 alkylsulfonyl(C.sub.0-8 alkyl)amino group, (16) a (C.sub.1-8 alkyl).sub.m9e-aminosulfonyl(C.sub.0-8 alkyl)amino group, m9e: 0.about.2, (17) a nitro group, (18) a hydroxy group, (19) a C.sub.1-8 alkoxy group which may be substituted by one or more R.sup.9G, R.sup.9G: [1] a hydroxy group, [2] a hydroxycarbonyl group, [3] a C.sub.6-10 aryl group which may be substituted by C.sub.1-8 alkoxy group(s), [4] a (C.sub.1-8 alkyl).sub.m9g1-amino group, [5] a C.sub.1-8 alkoxy group which may be substituted by one or more R.sup.9G1, [6] a 5- to 14-membered heteroaryl group, or [7] a 4- to 10-membered heterocycloalkyloxy group which may be substituted by C.sub.1-8 alkyl group(s), m9g1: 0.about.2, R.sup.9G1: [1] a C.sub.1-8 alkoxy group, or [2] a hydroxycarbonyl group, (20) a 4- to 10-membered heterocycloalkyloxy group which may be substituted by [1] 4- to 10-membered heterocycloalkyl group(s), or [2] C.sub.1-8 alkoxycarbonyl group(s), (21) a C.sub.1-8 alkylsulfonyloxy group which may be substituted by halogen atom(s), (22) a C.sub.1-8 alkylthio group which may be substituted by (C.sub.1-8 alkyl).sub.m9f-amino group(s), m9f: 0.about.2, (23) a C.sub.1-8 alkylsulfonyl group which may be substituted by (C.sub.1-8 alkyl).sub.m9g-amino group(s), m9g: 0.about.2, (24) a (C.sub.1-8 alkyl).sub.m9h-aminosulfonyl group, m9h: 0.about.2, (25) a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyl group which may be substituted by C.sub.1-8 alkyl group(s), and (26) a hydroxycarbonyl group.

2. The compound according to claim 1, or a salt or solvate thereof, wherein R.sup.3 is a cyano group or a halogen atom.

3. The compound according to claim 1, or a salt or solvate thereof, wherein A.sup.5 is NR.sup.5 and R.sup.5 is a hydrogen atom.

4. The compound according to claim 1, or a salt or solvate thereof, wherein: A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.7, A.sup.8, A.sup.9 and A.sup.10 all represent C; A.sup.5 is selected from NR.sup.5, O and S; R.sup.1 represents [1] a hydrogen atom, [2] a cyano group, or [3] a halogen atom; R.sup.2 is selected from the group consisting of: (1) a hydrogen atom, (2) a C.sub.1-8 alkyl group, (3) a cyano group, (4) a halogen atom, and (5) a (C.sub.1-8 alkyl)-amino group which may be substituted by C.sub.1-8 alkylsulfonyl group(s), m2: 0.about.2; R.sup.3 is selected from the group consisting of: (1) a hydrogen atom, (2) a C.sub.1-8 alkyl group which may be substituted by halogen atom(s), (3) a cyano group, (4) a (C.sub.1-8 alkyl).sub.m3a-aminocarbonyl group which may be substituted by one or more R.sup.3A, R.sup.3A: [1] a C.sub.6-10 aryl group, [2] a C.sub.1-8 alkoxy group, [3] a 5- to 14-membered heteroaryl group, or [4] a C.sub.6-10 aryl sulfonyl group, m3a: 0.about.2, (5) a hydroxycarbonyl group, (6) a C.sub.1-8 alkoxycarbonyl group which may be substituted by hydroxy group(s), (7) a halogen atom, (8) a (C.sub.1-8 alkyl).sub.m3b-amino group which may be substituted by C.sub.6-10 aryl group(s), m3b: 0.about.2, (9) a C.sub.1-8 alkylcarbonyl (C.sub.0-8 alkyl)amino group which may be substituted by [1] C.sub.6-10 aryl group(s) or [2] C.sub.6-10 aryloxy group(s), (10) a C.sub.6-10 arylcarbonyl (C.sub.0-8 alkyl)amino group which may be substituted by C.sub.1-8 alkyl group(s) which may be substituted by halogen atom(s), (11) a nitro group, (12) a hydroxy group, (13) a C.sub.1-8 alkoxy group which may be substituted by one or more R.sup.3B, R.sup.3B: [1] a hydroxy group, [2] a C.sub.1-8 alkoxy group, [3] a C.sub.6-10 aryl (C.sub.0-8 alkyl)aminocarbonyl group, [4] a (C.sub.1-8 alkyl).sub.m3d-amino group, or [5] a halogen atom, m3 d: 0.about.2, (14) a 4- to 10-membered heterocycloalkyloxy group, (15) a 5- to 14-membered heteroaryloxy group, (16) a (C.sub.1-8 alkyl).sub.m3e-aminocarbonyloxy group which may be substituted by C.sub.6-10 aryl group(s), m3e: 0.about.2, (17) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group, (18) a C.sub.1-8 alkylthio group, (19) a 5- to 14-membered heteroaryl group which may be substituted by C.sub.1-8 alkyl group(s) which may be substituted by C.sub.1-8 alkoxy group(s), (20) a C.sub.1-8 alkoxycarbonyl (C.sub.0-8 alkyl)amino group which may be substituted by C.sub.1-8 alkoxy group(s), (21) a C.sub.6-10 aryloxycarbonyl (C.sub.0-8 alkyl)amino group which may be substituted by C.sub.1-8 alkyl group(s) which may be substituted by halogen atom(s), (22) a C.sub.6-10 aryl (C.sub.0-8 alkyl)aminocarbonyl (C.sub.0-8 alkyl)amino group which may be substituted by C.sub.1-8 alkoxy group(s), (23) a C.sub.3-8 cycloalkyl (C.sub.0-8 alkyl)aminocarbonyloxy group, and (24) a C.sub.6-10 aryl (C.sub.0-8 alkyl)aminocarbonyloxy group which may be substituted by substituent(s) selected from the group consisting of [1] a C.sub.1-8 alkyl group and [2] a C.sub.1-8 alkoxy group; R.sup.4 is selected from the group consisting of: (1) a hydrogen atom, (2) a C.sub.1-8 alkyl group which may be substituted by halogen atom(s), (3) a C.sub.3-8 cycloalkyl group, (4) a cyano group, (5) an aminocarbonyl group, (6) a hydroxycarbonyl group, (7) a halogen atom, (8) a (C.sub.1-8 alkyl).sub.m4b-amino group, m4b: 0.about.2, (9) a hydroxy group, and (10) a C.sub.1-8 alkoxy group which may be substituted by hydroxy group(s); R.sup.5 is selected from the group consisting of: (1) a hydrogen atom, (2) a C.sub.1-8 alkyl group which may be substituted by one or more R.sup.5A, R.sup.5A: [1] a hydroxycarbonyl group, [2] a C.sub.1-8 alkoxycarbonyl group, [3] a hydroxy group, [4] a C.sub.1-8 alkoxy group, [5] a (C.sub.1-8 alkyl).sub.m5-amino group, or [6] a C.sub.1-8 alkylthio group, m5: 0.about.2, and (3) a C.sub.1-8 alkylsulfonyl group; R.sup.6 and R.sup.6' are each independently: (1) a C.sub.1-8 alkyl group, or R.sup.6 and R.sup.6' are taken together with the carbon atoms to which they are bound to form, (2) a C.sub.3-8 cycloalkyl group, or (3) a 4- to 10-membered heterocycloalkyl group; R.sup.7 is selected from the group consisting of: (1) a hydrogen atom, (2) a halogen atom, and (3) a C.sub.1-8 alkoxy group which may be substituted by one or more R.sup.7A, R.sup.7A: [1] a (C.sub.1-8 alkyl).sub.m7a-amino group, or [2] a hydroxy group, m7a:0.about.2; R.sup.8 is selected from the group consisting of: (1) a hydrogen atom, (2) a C.sub.1-8 alkyl group which may be substituted by one or more R.sup.8A, R.sup.8A: [1] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.8A1, [2] a (C.sub.1-8 alkyl).sub.m8a-amino group which may be substituted by a halogen atom, or [3] a hydroxy group, m8a:0.about.2, R.sup.8A1: [1] a C.sub.1-8 alkyl group, [2] a C.sub.1-8 alkylsulfonyl group, [3] a (C.sub.1-8 alkyl).sub.m8b-aminosulfonyl group, or [4] an oxo group, m8b: 0.about.2, (3) a C.sub.2-8 alkenyl group, (4) a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.8B, R.sup.8B: <1> a C.sub.1-8 alkyl group which may be substituted by one or more R.sup.8B1, <2> a C.sub.2-8 alkynyl group, <3> a C.sub.3-8 cycloalkyl group which may be substituted by [1] cyano group(s) or [2] C.sub.1-8 alkyl group(s), <4> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.8B2, <5> a C.sub.1-8 alkoxy group which may be substituted by substituent(s) selected from the group consisting of [1] a C.sub.1-8 alkoxy group and [2] a C.sub.3-8 cycloalkyl group, <6> a C.sub.1-8 alkylsulfonyl group, <7> an oxo group, <8> a cyano group, <9> a C.sub.1-8 alkanoyl group which may be substituted by one or more R.sup.8B3, <10> a C.sub.3-8 cycloalkylcarbonyl group, <11> a (C.sub.1-8 alkyl).sub.m8c-aminosulfonyl group, <12> a C.sub.1-8 alkylsulfonyl (C.sub.0-8 alkyl)amino group, <13> a (C.sub.1-8 alkyl).sub.m8d-amino group which may be substituted by one or more R.sup.8B4, <14> a hydroxy group, or <15> a (C.sub.1-8 alkyl).sub.m8e-aminocarbonyl group, m8c: 0.about.2, m8d: 0.about.2, m8e: 0.about.2, R.sup.8B1: [1] a C.sub.3-8 cycloalkyl group, [2] a hydroxy group, or [3] C.sub.1-8 alkoxy group, R.sup.8B2: [1] a halogen atom, [2] a C.sub.1-8 alkyl group, [3] an oxo group, or [4] a hydroxy group R.sup.8B2: [1] a halogen atom, [2] a C.sub.1-8 alkyl group, [3] an oxo group, or [4] a hydroxy group, R.sup.8B3: a (C.sub.1-8 alkyl).sub.m8f-amino group, m8f: 0.about.2, R.sup.8B4: [1] a C.sub.3-8 cycloalkyl group, or [2] a hydroxy group, (5) a 5- to 14-membered heteroaryl group which may be substituted by a C.sub.1-8 alkyl group, (6) a (C.sub.1-8 alkyl).sub.m8g-aminocarbonyl group which may be substituted by one or more R.sup.8C, m8g: 0.about.2, R.sup.8C: [1] a hydroxy group, [2] a (C.sub.1-8 alkyl).sub.m8h-amino group which may be substituted by substituent(s) selected from the group consisting of <1> a (C.sub.1-8 alkyl).sub.m8i-aminosulfonyl group and <2> a C.sub.1-8 alkylsulfonyl group, or [3] a C.sub.1-8 alkylsulfonyl group, m8h: 0.about.2, m8i: 0.about.2, (7) a 4- to 10-membered heterocycloalkyl (C.sub.0-8 alkyl)aminocarbonyl group which may be substituted by oxo group(s), (8) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by one or more R.sup.8D, R.sup.8D: [1] a C.sub.1-8 alkyl group which may be substituted by one or more R.sup.8D1, [2] a hydroxy group, or [3] a C.sub.1-8 alkylsulfonyl group, R.sup.8D1: [1] a hydroxy group, or [2] a C.sub.1-8 alkoxy group, (9) a hydroxycarbonyl group, (10) a C.sub.0-8 alkoxy (C.sub.0-8 alkyl)aminocarbonyl group which may be substituted by hydroxy group(s), (11) a halogen atom, (12) a (C.sub.1-8 alkyl).sub.m8j-amino group which may be substituted by 4- to 10-membered heterocycloalkyl group(s), m8j: 0.about.2, (13) a hydroxyl group, (14) a C.sub.1-8 alkoxy group which may be substituted by one or more R.sup.8E, R.sup.8E: <1> a hydroxy group, <2> a C.sub.1-8 alkoxycarbonyl group, <3> a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by one or more R.sup.8E1, <4> a (C.sub.1-8 alkyl).sub.m8k1-amino group which may be substituted by one or more R.sup.8E2, m8k1: 0.about.2, <5> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.8E3, <6> a 5- to 14-membered heteroaryl group, <7> a (C.sub.1-8 alkyl).sub.m8k2-aminocarbonyl group which may be substituted by one or more R.sup.8E6 m8k2: 0.about.2, <8> a C.sub.1-8 alkoxy group which may be substituted by one or more R.sup.8E7, <9> a C.sub.1-8 alkylthio group, <10> a C.sub.1-8 alkylsulfinyl group, or <11> a C.sub.1-8 alkylsulfonyl group, R.sup.8E1: <1> a C.sub.1-8 alkoxycarbonyl group, <2> a C.sub.1-8 alkanoyl group, <3> a C.sub.1-8 alkylsulfonyl group, <4> a (C.sub.1-8 alkyl).sub.m8k3-aminosulfonyl group m8k3: 0.about.2, or <5> a 4- to 10-membered heterocycloalkyl group, R.sup.8E2: <1> a hydroxy group, <2> a C.sub.1-8 alkoxycarbonyl group, <3> a C.sub.3-8 cycloalkyl group which may be substituted by C.sub.1-8 alkyl group(s) which may be substituted by hydroxy group(s), <4> a C.sub.1-8 alkanoyl group which may be substituted by substituent(s) selected from the group consisting of [1] a (C.sub.1-8 alkyl).sub.m8k4-amino group and [2] a halogen atom, m8k4: 0.about.2, <5> a (C.sub.1-8 alkyl).sub.m8k5-aminocarbonyl group, m8k5: 0.about.2, <6> a C.sub.1-8 alkylsulfonyl group, <7> a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyl group which may be substituted by C.sub.1-8 alkyl group(s), <8> a (C.sub.1-8 alkyl).sub.m8k6-aminosulfonyl group, m8k6: 0.about.2, or R.sup.8E3: <1> a C.sub.1-8 alkyl group which may be substituted by substituent(s) selected from the group consisting of [1] a hydroxy group and [2] a C.sub.1-8 alkylcarbonyloxy group, <2> a hydroxy group, <3> a C.sub.3-8 cycloalkyl group, <4> a C.sub.1-8 alkylsulfonyl group, <5> a (C.sub.1-8 alkyl).sub.m8k8-aminocarbonyl group, m8k8: 0.about.2, <6> a C.sub.1-8 alkanoyl group which may be substituted by hydroxy group(s), <7> an oxo group, or <8> a 4- to 10-membered heterocycloalkyl group which may be substituted by substituent(s) selected from the group consisting of [1] a C.sub.1-8 alkanoyl group, and [2] a C.sub.1-8 alkylsulfonyl group, R.sup.8E6: <1> a C.sub.2-8 alkenylcarbonyloxy group, <2> a hydroxy group, <3> a cyano group, <4> a (C.sub.1-8 alkyl).sub.m8k9-amino group which may be substituted by hydroxy group(s), m8k9: 0.about.2, <5> a C.sub.1-8 alkoxy group which may be substituted by hydroxy group(s), <6> a 4- to 10-membered heterocycloalkyl group which may be substituted by C.sub.1-8 alkyl group(s), or <7> a 5- to 14-membered heteroaryl group, R.sup.8E7: <1> a hydroxy group, or <2> a C.sub.1-8 alkoxy group which may be substituted by hydroxy group(s), (15) a 4- to 10-membered heterocycloalkyloxy group which may be substituted by one or more R.sup.8F: R.sup.8F: <1> a C.sub.1-8 alkyl group which may be substituted by one or more R.sup.8F1, <2> a C.sub.3-8 cycloalkyl group, <3> a C.sub.1-8 alkanoyl group which may be substituted by halogen atom(s), <4> a C.sub.1-8 alkoxycarbonyl group, <5> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.8F2, <6> a C.sub.1-8 alkyl sulfonyl group, or <7> a hydroxy group, R.sup.8F1: [1] a hydroxy group, [2] a C.sub.1-8 alkoxy group, or [3] a halogen atom, R.sup.8F2: [1] a 4- to 10-membered heterocycloalkyl group, [2] a C.sub.1-8 alkoxycarbonyl group, or [3] a C.sub.1-8 alkylsulfonyl group, (16) a 5- to 14-membered heteroaryloxy group, (17) a (C.sub.1-8 alkyl).sub.m8l1-aminosulfonyloxy group, m8l1: 0.about.2, (18) a C.sub.1-8 alkylthio group which may be substituted by (C.sub.1-8 alkyl).sub.m8l2-amino group(s), m8l2: 0.about.2, (19) a C.sub.1-8 alkylsulfonyl group which may be substituted by one or more R.sup.8G, R.sup.8G: [1] a hydroxycarbonyl group, [2] a hydroxy group, or [3] a (C.sub.1-8 alkyl).sub.m8l3-amino group, m8l3: 0.about.2, (20) a C.sub.2-8 alkenyloxy group, and (21) a C.sub.1-8 alkylsulfonyloxy group which may be substituted by halogen atom(s); R.sup.9 is selected from the group consisting of: (1) a hydrogen atom, (2) a C.sub.1-8 alkyl group which may be substituted by one or more R.sup.9A, R.sup.9A: [1] a C.sub.3-8 cycloalkyl group, [2] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.9A1, [3] a hydroxy group, or [4] a C.sub.1-8 alkoxy group, R.sup.9A1: [1] a C.sub.1-8 alkyl group, [2] a C.sub.3-8 cycloalkyl group, or [3] a 4- to 10-membered heterocycloalkyl group, (3) a C.sub.2-8 alkenyl group, (4) a C.sub.2-8 alkynyl group which may be substituted by one or more R.sup.9C, R.sup.9C: [1] a C.sub.1-8 alkoxy group, [2] a (C.sub.1-8 alkyl).sub.m9b-amino group which may be substituted by C.sub.6-10 aryl group(s), [3] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.9C1, [4] a C.sub.3-8 cycloalkyl group, [5] a hydroxy group, or [6] a hydroxycarbonyl group, m9b: 0.about.2, R.sup.9C1: [1] a C.sub.3-8 cycloalkyl group, [2] a 4- to 10-membered heterocycloalkyl group, or [3] an oxo group, (5) a C.sub.3-8 cycloalkyl group, (6) a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R.sup.9D, R.sup.9D: [1] a C.sub.1-8 alkyl group which may be substituted by 4- to 10-membered heterocycloalkyl group(s), [2] a C.sub.3-8 cycloalkyl group, [3] a 4- to 10-membered heterocycloalkyl group, or [4] a C.sub.1-6 alkylsulfonyl group, (7) a C.sub.6-10 aryl group which may be substituted by one or more R.sup.9E, R.sup.9E: [1] a halogen atom, [2] a hydroxy group, [3] a hydroxycarbonyl group, or [4] a C.sub.1-8 alkyl group which may be substituted by hydroxy group(s), (8) a 5- to 14-membered heteroaryl group which may be substituted by C.sub.1-8 alkyl group(s), (9) a cyano group, (10) a C.sub.1-8 alkanoyl group, (11) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by C.sub.1-8 alkyl group(s), (12) a halogen atom, (13) a (C.sub.1-8 alkyl).sub.m9e-amino group, m9c: 0.about.2, (14) a C.sub.1-8 alkylcarbonyl(C.sub.0-8 alkyl)amino group which may be substituted by (C.sub.1-8 alkyl).sub.m9d-amino group(s), m9d: 0.about.2, (15) a C.sub.1-8 alkylsulfonyl(C.sub.0-8 alkyl)amino group, (16) a (C.sub.1-8 alkyl).sub.m9e-aminosulfonyl(C.sub.0-8 alkyl)amino group, m9e: 0.about.2, (17) a nitro group, (18) a hydroxy group, (19) a C.sub.1-8 alkoxy group which may be substituted by one or more R.sup.9G, R.sup.9G: [1] a hydroxy group, [2] a hydroxycarbonyl group, [3] a C.sub.6-10 aryl group which may be substituted by C.sub.1-8 alkoxy group(s), [4] a (C.sub.1-8 alkyl).sub.m9g1-amino group, [5] a C.sub.1-8 alkoxy group which may be substituted by one or more R.sup.9G1, or [6] a 5- to 14-membered heteroaryl group, m9g1: 0.about.2, R.sup.9G1: [1] a C.sub.1-8 alkoxy group, or [2] a hydroxycarbonyl group, (20) a 4- to 10-membered heterocycloalkyloxy group which may be substituted by 4- to 10-membered heterocycloalkyl group(s), (21) a C.sub.1-8 alkylthio group which may be substituted by (C.sub.1-8 alkyl).sub.m9f-amino group(s), m9f: 0.about.2, (22) a C.sub.1-8 alkylsulfonyl group which may be substituted by (C.sub.1-8 alkyl).sub.m9g-amino group(s), m9g: 0.about.2, (23) a (C.sub.1-8 alkyl).sub.m9h-aminosulfonyl group, m9h: 0.about.2, and (24) a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyl group which may be substituted by C.sub.1-8 alkyl group(s); R.sup.10 represents [1] a hydrogen atom, or [2] a 4- to 10-membered heterocycloalkyl group which may be substituted by 4- to 10-membered heterocycloalkyl group(s)].

5. A compound or salt or solvate as claimed in claim 1 of 9-(4-isopropyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[- b]carbazole-3-carbonitrile.

6. A compound or salt or solvate as claimed in claim 1 of 6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-9-prop-1-ynyl-6,11-d- ihydro-5H-benzo[b]carbazole-3-carbonitrile.

7. A compound or salt or solvate as claimed in claim 1 of 9-cyclopropylethynyl-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo- -6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

8. A compound or salt or solvate as claimed in claim 1 of 6,6-dimethyl-8-(1-oxetan-3-yl-piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benz- o[b]carbazole-3-carbonitrile.

9. A compound or salt or solvate as claimed in claim 1 of 9-bromo-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro- -5H-benzo[b]carbazole-3-carbonitrile.

10. A compound or salt or solvate as claimed in claim 1 of 9-bromo-8-(4-cyclopropyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro- -5H-benzo[b]carbazole-3-carbonitrile.

11. A compound or salt or solvate as claimed in claim 1 of 9-chloro-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dih- ydro-5H-benzo[b]carbazole-3-carbonitrile.

12. A compound or salt or solvate as claimed in claim 1 of 8-(4-cyclobutyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-9-prop-1-ynyl-6,11-di- hydro-5H-benzo[b]carbazole-3-carbonitrile.

13. A compound or salt or solvate as claimed in claim 1 of 6,6,9-trimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5- H-benzo[b]carbazole-3-carbonitrile.

14. A compound or salt or solvate as claimed in claim 1 of 9-ethyl-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro- -5H-benzo[b]carbazole-3-carbonitrile.

15. A compound or salt or solvate as claimed in claim 1 of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihy- dro-5H-benzo[b]carbazole-3-carbonitrile.

16. A compound or salt or solvate as claimed in claim 1 of 9-ethynyl-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihyd- ro-5H-benzo[b]carbazole-3-carbonitrile.

17. A compound or salt or solvate as claimed in claim 1 of 8-(4-cyclobutyl-piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-- 5H-benzo[b]carbazole-3-carbonitrile.

18. A compound or salt or solvate as claimed in claim 1 of 9-ethynyl-6,6-dimethyl-11-oxo-8-(4-pyrrolidin-1-yl-piperidin-1-yl)-6,11-d- ihydro-5H-benzo[b]carbazole-3-carbonitrile.

19. A compound or salt or solvate as claimed in claim 1 of 6,6-dimethyl-11-oxo-8-(4-pyrrolidin-1-yl-piperidin-1-yl)-6,11-dihydro-5H-- benzo[b]carbazole-3-carbonitrile.

20. A compound or salt or solvate as claimed in claim 1 of 8-(4-cyclobutyl-piperazin-1-yl)-9-ethynyl-6,6-dimethyl-11-oxo-6,11-dihydr- o-5H-benzo[b]carbazole-3-carbonitrile.

21. A compound or salt or solvate as claimed in claim 1 of 8-(4-cyclobutyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-9-propyl-6,11-dihydro- -5H-benzo[b]carbazole-3-carbonitrile.

22. A compound or salt or solvate as claimed in claim 1 of 8-(1-isopropyl-piperidin-4-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[- b]carbazole-3-carbonitrile.

23. A compound or salt or solvate as claimed in claim 1 of 8-(4-isopropyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[- b]carbazole-3-carbonitrile.

24. A compound or salt or solvate as claimed in claim 1 of 8-(4-cyclobutyl-piperazin-1-yl)-9-cyclopropyl-6,6-dimethyl-11-oxo-6,11-di- hydro-5H-benzo[b]carbazole-3-carbonitrile.

25. A compound or salt or solvate as claimed in claim 1 of 8-(2-tert-butylamino-ethoxy)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]- carbazole-3-carbonitrile.

26. A compound or salt or solvate as claimed in claim 1 of 9-ethynyl-8-(4-methanesulfonyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-d- ihydro-5H-benzo[b]carbazole-3-carbonitrile.

27. A compound or salt or solvate as claimed in claim 1 of 9-bromo-8-(4-cyclobutyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-- 5H-benzo[b]carbazole-3-carbonitrile.

28. A compound or salt or solvate as claimed in claim 1 of 6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-9-propyl-6,11-dihydr- o-5H-benzo[b]carbazole-3-carbonitrile.

29. A compound or salt or solvate as claimed in claim 1 of 9-ethynyl-6,6-dimethyl-8-morpholin-4-yl-11-oxo-6,11-dihydro-5H-benzo[b]ca- rbazole-3-carbonitrile.
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