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Claims for Patent: 9,119,859

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Claims for Patent: 9,119,859

Title:Methods for treating otic infections
Abstract: The present invention relates to methods for treating an ophthalmic, otic, or nasal infection comprising treating the infected tissue with a composition comprising finafloxacin or a finafloxacin derivative. The present invention also relates to antimicrobial compositions comprising finafloxacin or a finafloxacin derivative. The compositions are suitable for the treatment of ophthalmic, otic, or nasal infections.
Inventor(s): Stroman; David W. (Irving, TX), Chowhan; Masood A. (Arlington, TX), Appell; Kenneth C. (Burleson, TX)
Assignee: Alcon Research, Ltd. (Fort Worth, TX)
Application Number:13/967,897
Patent Claims: 1. A method for treating acute otitis externa or acute otitis media with tympanostomy tubes, said method comprising: instilling a topical otic composition comprising finafloxacin into the external ear canal of a subject.

2. A method according to claim 1, said composition having a finafloxacin concentration of 0.3 to 0.4 w/v % and a pH of 5.0 to 6.0.

3. A method according to claim 2, said composition further comprising magnesium chloride at a concentration of 0.3 to 1.0 w/v %.

4. A method according to claim 1 wherein said topical otic composition further comprises an anti-inflammatory agent.

5. A method according to claim 4 wherein said anti-inflammatory agent is dexamethasone.

6. A method according to claim 5 wherein said dexamethasone is present at a concentration of 0.01 to 1.0 wt. %.
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