Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

QuintilesIMS
US Army
McKesson
Daiichi Sankyo
Healthtrust
US Department of Justice
Accenture
Dow
McKinsey

Generated: May 22, 2018

DrugPatentWatch Database Preview

Claims for Patent: 9,101,621

« Back to Dashboard

Summary for Patent: 9,101,621
Title:Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation
Abstract: Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Inventor(s): Zeldis; Jerome B. (Princeton, NJ)
Assignee: Celgene Corporation (Summit, NJ)
Application Number:14/255,211
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 9,101,621
Patent Claims: 1. A method of treating multiple myeloma, which comprises administering to a patient having multiple myeloma about 1 to about 50 mg per day of a compound having the formula: ##STR00009## or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, wherein the patient has previously received stem cell transplantation.

2. The method of claim 1, wherein the multiple myeloma is relapsed, refractory, or relapsed and refractory multiple myeloma.

3. The method of claim 1, wherein the compound is administered for 21 consecutive days followed by seven consecutive days of rest in a 28 day cycle.

4. The method of claim 1, wherein the compound is administered every day.

5. The method of claim 1, wherein the compound is administered orally.

6. The method of claim 1, wherein the compound is administered in the form of a capsule or tablet.

7. The method of claim 1, wherein the compound is administered in a capsule of 2.5 mg, 5 mg, 10 mg, 15 mg, 20 mg or 25 mg.

8. The method of claim 6, wherein the capsule comprises the compound, lactose anhydrous, microcrystalline cellulose, croscarmellose sodium and magnesium stearate.

9. The method of claim 1, wherein the compound is administered in an amount of about 25 mg per day.

10. The method of claim 1, wherein the compound is administered in an amount of about 15 mg per day.

11. The method of claim 1, wherein the compound is administered in an amount of about 10 mg per day.

12. The method of claim 1, wherein the compound is administered in an amount of about 5 mg per day.

13. The method of claim 3, wherein the compound is administered in an amount of about 25 mg per day.

14. The method of claim 4, wherein the compound is administered in an amount of about 5 mg, 10 mg or 15 mg per day.

15. The method of claim 1, wherein the stem cell transplantation is autologous stem cell transplantation.

16. The method of claim 1, wherein the stem cell transplantation is hematopoietic stem cell transplantation.

17. The method of claim 1, wherein the stem cell transplantation is peripheral blood stem cell transplantation.

18. The method of claim 1, wherein the compound is administered in an amount of about 2.5 mg per day.

19. The method of claim 3, wherein the compound is administered in an amount of about 10 mg per day.

20. The method of claim 1, wherein the compound is administered in an amount of about 20 mg per day.

21. The method of claim 1, wherein the compound is administered in a capsule containing from about 1 to about 50 mg of the compound.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Mallinckrodt
Chubb
US Department of Justice
McKesson
Cantor Fitzgerald
Argus Health
AstraZeneca
Merck
Cipla

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.