.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 9,023,397

« Back to Dashboard

Claims for Patent: 9,023,397

Title:Capsule and powder formulations containing lanthanum compounds
Abstract: The present invention includes an oral pharmaceutical capsule comprising a shell, lanthanum carbonate or lanthanum carbonate hydrate, and a lubricant such as talc, wherein the shell encapsulates the lanthanum carbonate or its hydrate and the lubricant. Capsule shells comprise, for example, gelatin. The present invention also includes an oral pharmaceutical powder comprising lanthanum carbonate or lanthanum carbonate hydrate and a pharmaceutically acceptable excipient. The oral pharmaceutical capsules and powders of the present invention can be administered to treat a patient at risk of or suffering from hyperphosphatemia, at risk of or suffering from chronic kidney disease (CKD), at risk of or suffering from soft tissue calcification associated with CKD, or at risk of or suffering from secondary hyperparathyroidism.
Inventor(s): Pierce; David (Hertfordshire, GB), Ferdinando; Josephine Christine (Tadley, GB), Davies; Peter Neil (Basingstoke, GB)
Assignee: Shire LLC (Florence, KY)
Application Number:14/507,551
Patent Claims: 1. An oral pharmaceutical powder comprising: (1) lanthanum carbonate, lanthanum carbonate hydrate, or a combination thereof, wherein the lanthanum carbonate or lanthanum carbonate hydrate comprises elemental lanthanum, and the elemental lanthanum is in an amount of about 26% by weight to about 50% by weight; (2) dextrates in an amount from about 5% to about 50% by weight; (3) one or more flow aids; and (4) one or more lubricants; wherein the weight % of elemental lanthanum is greater than the weight % of the dextrates.

2. The powder of claim 1, wherein the lanthanum carbonate or lanthanum carbonate hydrate has the formula: La.sub.2(CO.sub.3).sub.3.nH.sub.2O wherein n has a value from 0 to 10.

3. The powder of claim 2, wherein n has a value from 3 to 6.

4. The powder of claim 1, wherein the one or more flow aids is in an amount from about 0.1% to about 4% by weight.

5. The powder of claim 1, wherein the one or more flow aids is selected from the group consisting of silica, colloidal anhydrous silica, colloidal silicon dioxide, and a combination thereof.

6. The powder of claim 5, wherein the one or more flow aids is colloidal silicon dioxide.

7. The powder of claim 1, wherein the one or more lubricants is selected from the group consisting of magnesium stearate, talc, mineral oil, polyethylene glycol, silica, colloidal anhydrous silica, colloidal silicon dioxide, hydrogenated vegetable oil, glyceryl behenate, L-leucine, L-leucine/polyethylene glycol 6000, polyethylene glycol 6000, glyceryl monostearate, and a combination thereof.

8. The powder of claim 7, wherein the one or more lubricants is magnesium stearate.

9. The oral pharmaceutical powder of claim 1, wherein the powder is in an amount of about 750 mg or about 1000 mg elemental lanthanum.

10. The oral pharmaceutical powder of claim 1, wherein the powder is filled into one or more sachets, stick packs, or rigid containers.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc