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Last Updated: March 28, 2024

Claims for Patent: 8,999,996


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Summary for Patent: 8,999,996
Title:Hydrazide containing nuclear transport modulators and uses thereof
Abstract: The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.
Inventor(s): Sandanayaka; Vincent P. (Northboro, MA), Shacham; Sharon (Newton, MA), McCauley; Dilara (Cambridge, MA), Shechter; Sharon (Andover, MA)
Assignee: Karyopharm Therapeutics Inc. (Newton, MA)
Application Number:14/219,638
Patent Claims: 1. A compound represented by the following structural formula: ##STR00174## or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound represented by the following structural formula: ##STR00175## or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

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