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Last Updated: April 18, 2024

Claims for Patent: 8,999,379

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Summary for Patent: 8,999,379

Title:	Transparent transdermal nicotine delivery devices
Abstract:	A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%.
Inventor(s):	Gale; Robert M. (Los Altos, CA)
Assignee:	ALZA Corporation (Vacaville, CA)
Application Number:	14/192,811
Patent Claims:	1. A method for smoking cessation therapy, comprising: providing a transdermal nicotine delivery device comprising a backing layer formed from a material selected from the group consisting of PET/EVA laminates, HDPE/EAA/nylon/EAA multilaminate and a film comprising a graft copolymer formed from about 73-77% acrylonitrile and from about 23-27% methyl acrylate copolymerized in the presence of about 8-10 parts by weight of butadiene/acrylonitrile copolymers containing approximately 70% by weight of polymer units derived from butadiene, and a drug reservoir layer containing nicotine carried by the backing layer, wherein the device has an Opacity Index of less than 48.6% to permit the skin of a subject to which it is applied to be visible through the device; and applying the device to the skin of a subject. 2. The method according to claim 1, wherein the device further comprises an adhesive for maintaining the device in nicotine transmitting relationship with the skin of a subject. 3. The method according to claim 1, further comprising maintaining the device on the skin to deliver nicotine for 18-24 hours. 4. The method according to claim 1, wherein the backing has a nicotine permeability of less than 1.0 .mu.g/cm.sup.2/hr. 5. The method according to claim 1, wherein the backing has a nicotine permeability of less than 0.5 .mu.g/cm.sup.2/hr. 6. The method according to claim 1, wherein the backing has a solubility for nicotine of less than 1 wt %. 7. The method according to claim 1, wherein the backing has a solubility for nicotine of less than 0.1 wt %. 8. The method according to claim 1, wherein the device has an Opacity Index of less than 35.11%. 9. The method according to claim 1, wherein the device has an Opacity Index of less than 20%.

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