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Claims for Patent: 8,992,952

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Claims for Patent: 8,992,952

Title:Compositions for delivery of therapeutics into the eyes and methods for making and using same
Abstract: The present invention provides for compositions for administering a therapeutically effective amount of a therapeutic component. The compositions may include an ophthalmically acceptable carrier component; a therapeutically effective amount of a therapeutic component; and a retention component which may be effective to reduce wettability, induce viscosity, increase muco-adhesion, increase meniscus height on a cornea of an eye and/or increase physical apposition to a cornea of an eye of a composition.
Inventor(s): Vehige; Joseph G. (Laguna Niguel, CA), Chang; James N. (Newport Beach, CA), Graham; Richard (Irvine, CA), Lyons; Robert T. (Laguna Hills, CA), Kuan; Teresa H. (Placentia, CA), Chang; Chin-Ming (Tustin, CA)
Assignee: Allergan, Inc. (Irvine, CA)
Application Number:13/933,807
Patent Claims: 1. A topical ophthalmic solution consisting of: water; ketorolac, or a pharmaceutically acceptable salt thereof, in a range of 0.01% to 1.0% w/v; a mixture of medium molecular weight carboxymethyl cellulose and high molecular weight carboxymethyl cellulose wherein the medium and high molecular weight carboxymethyl cellulose is present in the solution in an amount of 0.1% w/v to 2.0% w/v and have a weight ratio between 0.25 and 4; sodium hydroxide and hydrochloric acid to adjust the pH; sodium chloride; a buffer; and having a pH in a range of about 6 to about 8.

2. The composition of claim 1, wherein the each of the medium and high molecular weight carboxymethyl cellulose is sodium carboxymethyl cellulose.

3. A topical ophthalmic solution consisting of: water; ketorolac, or a pharmaceutically acceptable salt thereof, in a range of 0.01% to 1.0% w/v; a mixture of medium molecular weight carboxymethyl cellulose and high molecular weight carboxymethyl cellulose wherein the medium and high molecular weight carboxymethyl cellulose is present in the solution in an amount of 0.1% w/v to 2.0% w/v and have a weight ratio between 0.25 and 4; sodium hydroxide and hydrochloric acid to adjust the pH; sodium chloride; a preservative; a buffer; and having a pH in a range of about 6 to about 8.

4. The topical ophthalmic solution of claim 1, wherein ketorolac is ketorolac tromethamine.

5. The topical ophthalmic solution of claim 1, wherein the sodium hydroxide and hydrochloric acid are 1N.

6. The topical ophthalmic solution of claim 1, wherein the solution has a pH of about 6.8.

7. The topical ophthalmic solution of claim 3, wherein the preservative is selected from the group consisting of benzalkonium chloride and chlorine dioxide.

8. The topical ophthalmic solution of claim 3, wherein ketorolac is ketorolac tromethamine.

9. The topical ophthalmic solution of claim 3, wherein the sodium hydroxide and hydrochloric acid are 1N.

10. The topical ophthalmic solution of claim 3, wherein the solution has a pH of about 6.8.
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