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|Title:||Capsule and powder formulations containing lanthanum compounds|
|Abstract:||The present invention includes an oral pharmaceutical capsule comprising a shell, lanthanum carbonate or lanthanum carbonate hydrate, and a lubricant such as talc, wherein the shell encapsulates the lanthanum carbonate or its hydrate and the lubricant. Capsule shells comprise, for example, gelatin. The present invention also includes an oral pharmaceutical powder comprising lanthanum carbonate or lanthanum carbonate hydrate and a pharmaceutically acceptable excipient. The oral pharmaceutical capsules and powders of the present invention can be administered to treat a patient at risk of or suffering from hyperphosphatemia, at risk of or suffering from chronic kidney disease (CKD), at risk of or suffering from soft tissue calcification associated with CKD, or at risk of or suffering from secondary hyperparathyroidism.|
|Inventor(s):||Pierce; David (Hertfordshire, GB), Ferdinando; Josephine Christine (Tadley, GB), Davies; Peter Neil (Basingstoke, GB)|
|Assignee:||Shire LLC (Florence, KY)|
1. An oral pharmaceutical powder comprising: (1) lanthanum carbonate or lanthanum carbonate hydrate in an amount of 68.14% by weight; (2) dextrates in an amount of
30.56% by weight; (3) colloidal silicon dioxide in an amount of 1.0% by weight; and (4) magnesium stearate in an amount of 0.3% by weight.
2. The oral pharmaceutical powder of claim 1, wherein the powder is in an amount of about 750 mg or about 1000 mg elemental lanthanum.
3. The oral pharmaceutical powder of claim 1, wherein the powder is filled into one or more sachets, stick packs, or rigid containers.
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