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Serving leading biopharmaceutical companies globally:

US Army
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Julphar
McKesson
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Generated: January 21, 2018

DrugPatentWatch Database Preview

Claims for Patent: 8,969,566

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Summary for Patent: 8,969,566
Title:Processes for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
Abstract: The present invention relates to compounds and processes for preparing compounds of Formula (I), ##STR00001## including compounds such as trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof (e.g., NXL-104).
Inventor(s): Ronsheim; Melanie Simone (Port Jefferson, NY), Racha; Saibaba (Smithtown, NY), Lawton; Graham Richard (Smithtown, NY), Zhou; Shao Hong (Commack, NY), Kalyan; Yuriy B. (Staten Island, NY), Golden; Michael (Macclesfield, GB), Milne; David (Macclesfield, GB), Telford; Alexander (Macclesfield, GB), Cherryman; Janette (Macclesfield, GB), Boyd; Alistair (Cheshire, GB), Phillips; Andrew (Macclesfield, GB), Dedhiya; Mahendra G. (Pomona, NY)
Assignee:
Application Number:14/180,656
Patent Claims: 1. A process for preparing a compound of Formula (IX) comprising: ##STR00069## (a) treating a compound of Formula (XI) ##STR00070## with a source of ammonia or ammonia proxy to yield a compound of Formula (XIV): ##STR00071## (b) treating the compound of Formula (XIV) with a protecting group and a carbonylation agent to yield a compound of Formula (XVII): ##STR00072## (c) treating the compound of Formula (XVII) with a source of tetra n-butylammonium ion to yield a compound of Formula (XIX): ##STR00073## (d) treating the compound of Formula (XIX) with a source of sodium; wherein R8 is selected from the group consisting of substituted or unsubstituted alkyl, allyl, aryl and benzyl and R9 is a hydroxylamine protecting group.

2. The process of claim 1, wherein R8 is selected from the group consisting of methyl, ethyl and benzyl.

3. The process of claim 1, wherein R8 is benzyl.

4. The process of claim 1, wherein R9 is selected from the group consisting of allyl and trialkylsilyl.

5. The process of claim 1, wherein R9 is benzyl.

6. The process of claim 1, comprising treating the compound of Formula (XIV) with 9-fluorenylmethoxycarbonyl.

7. The process of claim 1, comprising treating the compound of Formula (XIV) with N,N-carbonyl diimidazole.

8. The process of claim 1, comprising treating the compound of Formula (XVII) with a SO.sub.3 complex.

9. ({[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl]oxy}sulph- onyl)oxidanide prepared according to the process of claim 1.

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Serving leading biopharmaceutical companies globally:

Colorcon
QuintilesIMS
McKesson
Johnson and Johnson
Accenture
US Department of Justice
Julphar
Boehringer Ingelheim
Covington

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