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Claims for Patent: 8,937,062

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Claims for Patent: 8,937,062

Title:Compositions and methods for treating, reducing, ameliorating, or preventing infections caused by antibacterial drug-resistant bacteria
Abstract: Compositions comprise a fluoroquinolone having Formulae I-VIII for treating, reducing, ameliorating, or preventing infections caused by some bacteria that are resistant to an antibacterial drug. Methods for treating, reducing, ameliorating, or preventing such infections use such compositions.
Inventor(s): Tyle; Praveen (Pittsford, NY), Gupta; Pramod Kumar (Pittsford, NY), Norton; Susan E. (Rochester, NY), Brunner; Lynne (Webster, NY), Blondeau; Joseph (Saskatoon, CA)
Assignee: Bausch & Lomb Incorporated (Rochester, NY)
Application Number:12/051,289
Patent Claims: 1. A method for treating, reducing, or ameliorating all infection in a subject, the method comprising administering to said subject in need thereof a composition comprising: (a) a fluoroquinolone having Formula IV or a salt thereof present in an amount effective to treat, reduce, or ameliorate an infection caused by ofloxacin-resistant Enterobacteriaceae with MIC.sub.90 range of 4-32 .mu.g/ml in vitro, ofloxacin-resistant S. aureus with MIC.sub.90 range of 0.5-8 .mu.g/ml in vitro, levofloxacin-resistant S. pneumonia with MIC.sub.90 range of 0.5-8 .mu.g/ml in vitro, gentamicin-resistant S. aureus with MIC.sub.90 range of 0.006-8 .mu.g/ml in vitro, ampicillin-resistant H. influenza with MIC.sub.90 less than or equal to 0.06 .mu.g/ml in vitro, or vancomycin-resistant S. aureus with MIC.sub.90 range of 1-4 .mu.g/ml in vitro; or (b) a fluoroquinolone having Formula VI present in an amount effective to treat, reduce, or ameliorate an infection caused by gentamicin-resistant S. aureus with MIC.sub.90 range of 0.006-4 .mu.g/m in vitro or ampicillin-resistant H. influenza with MIC.sub.90 less than or equal to 0.06 .mu.g/ml in vitro; ##STR00007##

2. The method of claim 1, wherein the composition is administered topically, orally, or systemically.

3. The method of claim 1, where the composition is administered topically.

4. The method of claim 1, wherein the infection is an infection of an eye, ear, respiratory system, or a combination thereof.

5. A method for treating, reducing, or ameliorating an infection in a subject, the method comprising: (a) ascertaining that a specimen from a site of infection contains a bacterium that is resistant to an antibacterial drug that is selected from the group consisting of gentamycin, vancomycin, ofloxacin, ciprofloxacin, and levofloxacin; and (b) administering to said subject in need thereof a composition comprising (i) a fluoroquinolone having Formula IV or a salt thereof present in an amount effective to treat, reduce, or ameliorate an infection caused by ofloxacin-resistant Enterobacteriaceae with MIC.sub.90 range of 4-32 .mu.g/ml in vitro, ofloxacin-resistant S. aureus with MIC.sub.90 range of 0.5-8 .mu.g/ml in vitro, levofloxacin-resistant S. pneumonia with MIC.sub.90 range of 0.5-8 .mu.g/ml in vitro, gentamicin-resistant S. aureus with MIC.sub.90 range of 0.006-8 .mu.g/ml in vitro, ampicillin-resistant H. influenza with MIC.sub.90 less than or equal to 0.06 .mu.g/ml in vitro, or vancomycin-resistant S. aureus with MIC.sub.90 range of 1-4 .mu.g/ml in vitro; or (ii) a fluoroquinolone having Formula VI present in an amount effective to treat, reduce, or ameliorate an infection caused by, ofloxacin-resistant S. aureus with MIC.sub.90 range of 0.5-8 .mu.g/ml in vitro or ampicillin-resistant H. influenza with MIC.sub.90 less than or equal to 0.06 .mu.g/ml in vitro; ##STR00008##
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