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Last Updated: April 5, 2026

Claims for Patent: 8,906,938

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Summary for Patent: 8,906,938

Title:	C5aR antagonists
Abstract:	Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
Inventor(s):	Pingchen Fan, Kevin Lloyd Greenman, Manmohan Reddy Leleti, Yandong Li, Jay P. Powers, Hiroko Tanaka, Ju Yang, Yibin Zeng
Assignee:	Chemocentryx Inc
Application Number:	US13/894,209
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,906,938
Patent Claims:	1. A compound having the formula or a pharmaceutically acceptable salt or rotamer thereof. 2. The compound of claim 1, in a pharmaceutically acceptable salt form. 3. A composition comprising a pharmaceutically acceptable carrier and a compound having the formula: or a pharmaceutically acceptable salt, hydrate or rotamer thereof. 4. A compound having the formula: 5. A pharmaceutical composition comprising a compound having the formula and a pharmaceutically acceptable carrier.

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