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Serving hundreds of leading biopharmaceutical companies globally:

Merck
Deloitte
AstraZeneca
Argus Health
Chinese Patent Office
Boehringer Ingelheim
Farmers Insurance
Johnson and Johnson
Cipla

Generated: April 26, 2018

DrugPatentWatch Database Preview

Claims for Patent: 8,906,851

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Summary for Patent: 8,906,851
Title:Method for treating diabetes
Abstract: Methods for reducing body weight, altering body composition, treating diabetes, reducing HbA.sub.1c and reducing average daily blood glucose by the use of exendins, exendin agonists or exendin analog agonists are provided.
Inventor(s): Fineman; Mark (San Diego, CA), MacConell; Leigh (San Diego, CA), Taylor; Kristin (San Diego, CA)
Assignee: Amylin Pharmaceuticals, LLC (San Diego, CA) AstraZeneca Pharmaceuticals LP (Wilmington, DE)
Application Number:13/708,474
Patent Claims: 1. A method for treating diabetes in a human in need thereof comprising administering once weekly to the human a therapeutically effective amount of a pharmaceutical composition comprising exendin-4 to achieve a mean steady state plasma concentration of the exendin-4 of at least 170 pg/ml for at least one month in the human to treat diabetes, wherein the pharmaceutical composition further comprises a sugar.

2. The method of claim 1, wherein the exendin 4 is present in the pharmaceutical composition in an amount of 1.0 mg to 5.0 mg.

3. The method of claim 1, wherein the pharmaceutical composition comprises 5% (w/w) exendin-4, 2% (w/w) sucrose, and 93% (w/w) poly(lactide-co-glycolide)copolymer.

4. The method of claim 1, wherein the mean steady state plasma concentration of exendin 4 is 170 pg/ml to 600 pg/ml.

5. The method of claim 1, wherein the mean steady state plasma concentration of exendin 4 is 170 pg/ml to 350 pg/ml.

6. The method of claim 1, wherein the mean steady state plasma concentration of exendin 4 is 170 pg/ml to 290 pg/ml.

7. The method of claim 1, wherein the diabetes is type 2 diabetes.

8. The method of claim 1, wherein the diabetes is type 1 diabetes.

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Serving hundreds of leading biopharmaceutical companies globally:

Healthtrust
McKinsey
Teva
Mallinckrodt
UBS
Medtronic
US Department of Justice
Colorcon
Merck

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