|Title:||Compositions for increasing solubility of azole drug compounds that are poorly soluble in water|
|Abstract:||The combination of any two of a polyol, a polyol ether, and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds, such as metronidazole, in aqueous fluid.|
|Inventor(s):||Yang; Meidong (Richmond, CA), Chen; Haigang (Edina, MT)|
|Assignee:||Dow Pharmaceutical Sciences, Inc. (Petaluma, CA)|
1. A pharmaceutical composition comprising water and at least about 1.25% w/w metronidazole to about 1.5% w/w metronidazole, wherein the composition further comprises
at least two of a polyol, a polyol ether, and a low carbon organic alcohol.
2. The composition of claim 1 wherein the low carbon organic alcohol is benzyl alcohol.
3. The composition of claim 2 wherein the benzyl alcohol comprises about 1% w/w of the composition.
4. The composition of claim 2 wherein the benzyl alcohol comprises about 2% w/w of the composition.
5. The composition of claim 1 wherein the polyol is propylene glycol.
6. The composition of claim 1 wherein the polyol ether is an ether of an alkylene glycol.
7. The composition of claim 6 wherein the ether of the alkylene glycol is polyethylene glycol.
8. The composition of claim 7 wherein the polyethylene glycol is polyethylene glycol 400 ("PEG 400").
9. The composition of claim 1 wherein the water comprises about 55% or more w/w of the composition.
10. The composition of claim 1 wherein the composition comprises each of a polyol, a polyol ether, and a low carbon organic alcohol.
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