.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 8,859,623

« Back to Dashboard

Claims for Patent: 8,859,623

Title:Methods and compositions of stable phenylephrine formulations
Abstract: The invention is directed to methods and compositions of stabilizing phenylephrine formations. The composition has good time-dependent stability at low temperature and has no change in its outward appearance even after having been stored at least 6 months.
Inventor(s): Witham; Patrick H. (Eugene, OR), Machiraju; Sailaja (Beaverton, OR), Bluett; Lauren Mackensie-Clark (Milwaukie, OR)
Assignee: Paragon Bioteck, Inc. (Portland, OR)
Application Number:14/080,771
Patent Claims: 1. A method of using an ophthalmic composition for pupil dilation, the composition comprising R-phenylephrine hydrochloride having an initial chiral purity of at least 95% and an aqueous buffer, wherein the chiral purity of R-phenylephrine hydrochloride is at least 95% of the initial chiral purity after 6 months, the method comprising: administering the composition into an eye of an individual in need thereof, wherein the composition is stored between -10 to 10 degree Celsius prior to administration, and wherein the composition comprises R-phenylephrine hydrochloride having a chiral purity of at least 95% when administered after storage.

2. The method of claim 1, wherein the composition is allowed to be stored between 2 to 8 degree Celsius.

3. The method of claim 1, wherein the composition comprises R-phenylephrine hydrochloride having an initial chiral purity of at least 99%.

4. The method of claim 1, wherein the composition comprises R-phenylephrine hydrochloride having an initial chiral purity of at least 99.3%.

5. The method of claim 1, wherein the chiral purity of R-phenylephrine hydrochloride is at least 97% of the initial chiral purity after 6 months.

6. The method of claim 1, wherein the chiral purity of R-phenylephrine hydrochloride is at least 99% of the initial chiral purity after 6 months.

7. The method of claim 1, wherein the chiral purity of R-phenylephrine hydrochloride is at least 99.5% of the initial chiral purity after 6 months.

8. The method of claim 1, wherein the composition comprises 2.5% w/v or 10% w/v R-phenylephrine hydrochloride by weight.

9. The method of claim 1, wherein the composition is packaged in a 1-15 ml plastic or glass bottle.

10. The method of claim 9, wherein the package identifies storing the composition at a temperature between -10 to 10 C.

11. The method of claim 10, wherein the package identifies storing the composition at a temperature between 2 to 8 C.

12. The method of claim 9, wherein the composition is in a plastic or glass bottle of about 2 ml, about 3 ml, about 5 ml, about 10 ml or about 15 ml.

13. The method of claim 9, wherein the plastic or glass bottle is opaque.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc