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Claims for Patent: 8,841,446

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Claims for Patent: 8,841,446

Title:Medicaments containing vardenafil hydrochloride trihydrate
Abstract: The invention relates to a method for producing medicaments that contain vardenafil hydrochloride, essentially as trihydrate in solid form, and to medicaments that can be obtained according to this method.
Inventor(s): Serno; Peter (Gladbach, DE), Grunenberg; Alfons (Dormagen, DE), Ohm; Andreas (Neuss, DE), Bellinghausen; Rainer (Odenthal, DE), Vollers; Elmer (Leverkusen, DE), Henck; Jan-Olav (Willich, DE)
Assignee: Bayer Intellectual Property GmbH (Monheim, DE)
Application Number:13/625,481
Patent Claims: 1. A coated tablet comprising 0.1-70% by weight vardenafil hydrochloride, primarily in the form of vardenafil hydrochloride trihydrate, 0.1-10% by weight disintegrant, 0.1-2% by weight lubricant, and fillers as remaining ingredients, characterized in that the vardenafil hydrochloride trihydrate content of the vardenafil hydrochloride is at least 90 mol %.

2. A coated tablet as claimed in claim 1 comprising microcrystalline cellulose as filler.

3. A coated tablet as claimed in claim 1 comprising crospovidone as disintegrant.

4. A coated tablet as claimed in claim 1 comprising magnesium stearate as lubricant.

5. A coated tablet as claimed in claim 1 comprising microcrystalline cellulose as filler, crospovidone as disintegrant and magnesium stearate as lubricant.

6. A coated tablet as claimed in claim 1 comprising 4% by weight vardenafil hydrochloride trihydrate.

7. A coated tablet as claimed in claim 1 comprising 7% by weight vardenafil hydrochloride trihydrate.

8. A coated tablet as claimed in claim 1 comprising 9% by weight vardenafil hydrochloride trihydrate.

9. A coated tablet as claimed in claim 1 comprising 13% by weight vardenafil hydrochloride trihydrate.

10. A coated tablet as claimed in claim 1 comprising 5% by weight crospovidone.

11. A coated tablet as claimed in claim 1 comprising 1% by weight magnesium stearate.

12. A coated tablet as claimed in claim 1 comprising microcrystalline cellulose as filler, crospovidone as disintegrant, magnesium stearate as lubricant and 4% by weight vardenafil hydrochloride trihydrate.

13. A coated tablet as claimed in claim 1 comprising microcrystalline cellulose as filler, crospovidone as disintegrant, magnesium stearate as lubricant and 7% by weight vardenafil hydrochloride trihydrate.

14. A coated tablet as claimed in claim 1 comprising microcrystalline cellulose as filler, crospovidone as disintegrant, magnesium stearate as lubricant and 9% by weight vardenafil hydrochloride trihydrate.

15. A coated tablet as claimed in claim 1 comprising microcrystalline cellulose as filler, crospovidone as disintegrant, magnesium stearate as lubricant and 13% by weight vardenafil hydrochloride trihydrate.
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