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Claims for Patent: 8,841,330

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Claims for Patent: 8,841,330

Title:Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
Abstract: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
Inventor(s): Riedl; Bernd (Wuppertal, DE), Dumas; Jacques (Orange, CT), Khire; Uday (Hamden, CT), Lowinger; Timothy B. (Nishinomiya, JP), Scott; William J. (Guilford, CT), Smith; Roger A. (Madison, CT), Wood; Jill E. (North Haven, CT)
Assignee: Bayer Healthcare LLC (Whippany, NJ)
Application Number:13/368,812
Patent Claims: 1. A method for the treatment of a tumor of the prostate, breast, liver, ovary or cervix in a human or animal comprising administering an effective amount of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00186## or a pharmaceutically acceptable salt thereof.

2. A method as in claim 1 wherein the tumor is of the prostate.

3. A method of claim 1 wherein the tumor is of the breast.

4. A method of claim 1 wherein the tumor is of the liver.

5. A method of claim 1 wherein the tumor is of the ovary.

6. A method of claim 1 wherein the tumor is of the cervix.

7. A method for the treatment of a tumor of the prostate, breast, liver, ovary or cervix in a human or animal comprising administering an effective amount of a tosylate salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00187##

8. A method as in claim 7 wherein the tumor is of the prostate.

9. A method of claim 7 wherein the tumor is of the breast.

10. A method of claim 7 wherein the tumor is of the liver.

11. A method of claim 7 wherein the tumor is of the ovary.

12. A method of claim 7 wherein the tumor is of the cervix.

13. A method for the treatment of liver cancer in a human or animal in need thereof comprising administering an effective amount of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00188## or a pharmaceutically acceptable salt thereof.

14. A method of claim 13 wherein a tosylate salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyr- idyloxy)phenyl)urea of the formula: ##STR00189## is administered.
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