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Claims for Patent: 8,841,278

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Claims for Patent: 8,841,278

Title:Antiviral compounds
Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Inventor(s): Bacon; Elizabeth M. (Burlingame, CA), Canales; Eda (San Mateo, CA), Cho; Aesop (Mountain View, CA), Cottell; Jeromy J. (Redwood City, CA), Desai; Manoj C. (Pleasant Hill, CA), Graupe; Michael (Pacifica, CA), Guo; Hongyan (San Mateo, CA), Halcomb; Randall L. (Foster City, CA), Kato; Darryl (San Francisco, CA), Kim; Choung U. (San Carlos, CA), Kirschberg; Thorsten A. (Redwood City, CA), Krygowski; Evan S. (Washington, CA), Lazerwith; Scott E. (San Francisco, CA), Link; John O. (San Francisco, CA), Liu; Hongtao (Cupertino, CA), Liu; Qi (Union City, CA), Mackman; Richard L. (Millbrae, CA), Mitchell; Michael L. (Castro Valley, CA), Parrish; Jay P. (El Dorado Hills, CA), Pyun; Hyung-Jung (Fremont, CA), Saugier; Joseph H. (Livermore, CA), Schroeder; Scott D. (Foster City, CA), Sun; Jianyu (Surrey, CA), Taylor; James G. (San Mateo, CA), Trenkle; James D. (Oakland, CA), Tse; Winston C. (Redwood City, CA), Vivian; Randall W. (San Mateo, CA), Watkins; William J. (Saratoga, CA), Xu; Lianhong (Palo Alto, CA)
Assignee: Gilead Pharmasset LLC (Foster City, CA)
Application Number:14/045,717
Patent Claims: 1. A pharmaceutical composition comprising a compound of the following formula: ##STR01319## an inhibitor of NS5B polymerase, and a pharmaceutically acceptable carrier.

2. The pharmaceutical composition of claim 1, wherein the inhibitor of NS5B polymerase is a non-nucleoside inhibitor.

3. The pharmaceutical composition of claim 1, wherein the inhibitor of NS5B polymerase is a nucleoside or nucleotide inhibitor.

4. A method of inhibiting hepatitis C virus in a patient in need thereof comprising administering to the patient the pharmaceutical composition of claim 1.

5. A method of inhibiting hepatitis C virus in a patient in need thereof comprising administering to the patient a compound of the following formula: ##STR01320## and an inhibitor of NS5B polymerase.

6. The method of claim 5, wherein the inhibitor of NS5B polymerase is a non-nucleoside inhibitor.

7. The method of claim 5, wherein the inhibitor of NS5B polymerase is a nucleoside or nucleotide inhibitor.
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