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|Title:||2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole and estrogen formulations|
|Abstract:||The present invention relates to new formulations containing one or more estrogens and 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below: ##STR00001##|
|Inventor(s):||Pickar; James H (Springfield, PA), Komm; Barry S (Havertown, PA)|
|Assignee:||Wyeth LLC (New York, NY)|
|Patent Claims:||1. A pharmaceutical composition comprising an oral dosage comprising a tablet or capsule for the treatment of post-menopausal syndrome comprising conjugated estrogens, in the amount of about 0.3 mg, to about 2.5 mg and 1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indo- l-5-ol or a pharmaceutically acceptable salt thereof, in the amount of from about 1 mg to about 150 mg, and a pharmaceutically acceptable carrier or excipient.|
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