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Claims for Patent: 8,809,615

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Claims for Patent: 8,809,615

Title:Adhesive preparation
Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m.sup.224 hr measured at a temperature of 40.degree. C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC.sub.0-24 ranging from 3.0 to 60.0 nghr/mL in terms of a mean.+-.standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC.sub.0-24 ranging from 5000 to 13000 nghr/mL in terms of a mean.+-.standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m.sup.2 and a contact area is 280 cm.sup.2.
Inventor(s): Tsuruda; Kiyomi (Tosu, JP), Yamasoto; Shinji (Tosu, JP), Shoho; Kouki (Tosu, JP), Nakanishi; Masaru (Tsukuba, JP)
Assignee: Hisamitsu Pharmaceutical Co., Inc. (Tosu-shi, Saga, JP)
Application Number:12/588,721
Patent Claims: 1. An adhesive preparation comprising: a stretchable support and an adhesive layer, wherein the adhesive layer is laminated on at least one side of the support and comprises a thermoplastic elastomer, and 10% by mass or more of methyl salicylate with respect to the total mass of the layer, wherein the whole adhesive preparation has moisture permeability of 1 to 350 g/m.sup.224 hr measured at a temperature of 40.degree. C. and a relative humidity of 90%, and wherein the methyl salicylate has a plasma AUC.sub.0-24 per unit area ranging from 1.0.times.10.sup.-2 to 2.1.times.10.sup.-1 nghr/mL/cm.sup.2 in terms of a mean.+-.standard deviation, and a salicylic acid as a metabolite of the methyl salicylate has a plasma AUC.sub.0-24 per unit area ranging from 17.8 to 46.4 nghr/mL/cm.sup.2 in terms of a mean.+-.standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer is 50 to 300 g/m.sup.2.

2. The adhesive preparation according to claim 1, wherein adhesive layer contains 1% by mass or more of I-menthol with respect to the total mass of the layer.

3. The adhesive preparation according to claim 2, wherein the I-menthol has a plasma AUC.sub.0-24 per unit area ranging from 1.0.times.10.sup.-1 to 4.6.times.10.sup.-1 nghr/mL/cm.sup.2 in terms of a mean.+-.standard deviation, and a plasma C.sub.max per unit area ranging from 1.7.times.10.sup.-2 to 7.1.times.10.sup.-2 ng/mL/cm.sup.2 in terms of a mean.+-.standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer is 50 to 300 g/m.sup.2.

4. The adhesive preparation according to claim 1, wherein the adhesive layer comprises a tackifier.

5. The adhesive preparation according to claim 4, wherein the tackifier comprises one or more selected from the group consisting of a rosin-based resin and a petroleum-based resin.

6. The adhesive preparation according to claim 4, wherein the tackifier is present in the adhesive preparation from 10% by mass to 30% by mass with respect to the total mass of the adhesive layer.

7. The adhesive preparation according to claim 1, wherein the stretchable support comprises a longitudinal modulus of 2 to 12 N/5 cm and a lateral modulus of 2 to 8 N/5 cm.

8. The adhesive preparation according to claim 1, wherein the stretchable support comprises a weight per unit area of 80 to 150 g/m.sup.2.

9. The adhesive preparation according to claim 1, wherein the stretchable support comprises an interlock woven fabric.

10. The adhesive preparation according to claim 1, wherein the methyl salicylate has a plasma C.sub.max per unit area ranging from 7.1.times.10.sup.-3 to 1.4.times.10.sup.-1 ng/mL/cm.sup.2 in terms of a mean.+-.standard deviation, and the salicylic acid has a plasma C.sub.max per unit area ranging from 2.5 to 7.1 ng/mL/cm.sup.2 in terms of a mean.+-.standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer is 50 to 300 g/m.sup.2.

11. The adhesive preparation according to claim 1, wherein the thermoplastic elastomer is one or more selected from the group consisting of a styrene-isoprene-styrene block copolymer, a styrene-butadiene-styrene block copolymer, a styrene-isoprene rubber, a styrene-butadiene rubber, polyisoprene, polybutadiene, and polyisobutylene.

12. The adhesive preparation according to claim 1, wherein the thermoplastic elastomer is present in the adhesive preparation from 25% by mass to 50% by mass with respect to the total mass of the adhesive layer.
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