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Claims for Patent: 8,791,140

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Claims for Patent: 8,791,140

Title:Crystalline forms of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-E-[2-(pyridin-2-yl)ethenyondazole suitable for the treatment of abnormal cell growth in mammals
Abstract: The present invention relates to crystalline polymorphic and amorphous form of 6-[2-(methylcarbamoyl)phenyl sulfanyl]-3-E-[2-(pyridin-2-yl)ethenyl]indazole and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one polymorphic form and to the therapeutic or prophylactic use of such polymorphic forms and compositions.
Inventor(s): Campeta; Anthony Michael (Ledyard, CT), Chekal; Brian Patrick (Niantic, CT), Singer; Robert Alan (Niantic, CT)
Assignee: Pfizer Inc. (New York, NY)
Application Number:12/594,575
Patent Claims: 1. A crystalline form of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-E-[2-(pyridin-2-yl)ethenyl]indazo- le, wherein said crystalline form has a powder X-ray diffraction pattern comprising a peak at diffraction angle (2.theta.) of 6.0.+-.0.1 and further comprising at least one peak at diffraction angle (2.theta.) selected from 11.5.+-.0.1, 21.0.+-.0.1 and 26.9.+-.0.1.

2. A crystalline form of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-E-[2-(pyridin-2-yl)ethenyl]indazo- le, wherein said crystalline form has a powder X-ray diffraction pattern comprising a peak at diffraction angle (2.theta.) of 6.0.+-.0.1, 11.9.+-.0.1 and 22.8.+-.0.1.

3. A crystalline form of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-E-[2-(pyridin-2-yl)ethenyl]indazo- le, wherein said crystalline form has a powder X-ray diffraction pattern comprising a peak at diffraction angle (2.theta.) of 11.9.+-.0.1 and 21.0.+-.0.1, and further comprising at least one peak at diffraction angle (2.theta.) selected from 22.8.+-.0.1, 23.1.+-.0.1 and 26.9.+-.0.1.

4. A crystalline form of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-E-[2-(pyridin-2-yl)ethenyl]indazo- le, wherein said crystalline form has a powder X-ray diffraction pattern comprising a peak at diffraction angle (2.theta.) of 11.5.+-.0.1 and 15.6.+-.0.1, and further comprising at least one peak at diffraction angle (2.theta.) selected from 16.2.+-.0.1 and 16.5.+-.0.1.

5. A crystalline form of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-E-[2-(pyridin-2-yl)ethenyl]indazo- le, wherein said crystalline form has a solid state NMR spectrum comprising .sup.13C chemical shifts at 150.1.+-.0.2, 136.6.+-.0.2, 135.+-.0.2, 116.9.+-.0.2 and 27.5.+-.0.2 ppm.

6. A crystalline form of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-E-[2-(pyridin-2-yl)ethenyl]indazo- le, wherein said crystalline form has a powder X-ray diffraction pattern comprising a peak at diffraction angle (2.theta.) of 6.0.+-.0.1 and 11.5.+-.0.1 and wherein said crystalline form has a solid state NMR spectrum comprising .sup.13C chemical shifts at 150.1.+-.0.2 and 27.5.+-.0.2 ppm.
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