.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 8,784,878

« Back to Dashboard

Claims for Patent: 8,784,878

Title:Transdermal delivery rate control using amorphous pharmaceutical compositions
Abstract: A pharmaceutical composition for transdermal delivery comprising one or more physiologically active agents; one or more dermal penetration enhancers; and a volatile pharmaceutically acceptable carrier comprising a volatile solvent; and wherein the physiologically active agent and dermal penetration enhancer form an amorphous deposit upon evaporation of the volatile carrier, said amorphous deposit forming a reservoir within the stratum corneum; and (A) wherein the composition has a release rate profile of physiologically active agent so as to provide a ratio of the maximum concentration (C.sub.max) to the average concentration (C.sub.avg) for the physiologically active agent over the dosage interval within the range of 1 to 10.
Inventor(s): Morgan; Timothy Matthias (Carlton North, AU), Wilkins; Nina Frances (Kensington, AU), Klose; Kathryn Traci-Jane (Bonreach, AU), Finnin; Barrie Charles (Toorak, AU), Reed; Barry Leonard (Essendon, AU)
Assignee: Acrux DDS Pty Ltc. (West Melbourne, Victoria, AU)
Application Number:13/710,761
Patent Claims: 1. A non-occlusive transdermal pharmaceutical composition for the transdermal delivery of testosterone, comprising: (a) from 0.1% to 10% by weight of testosterone; (b) from 0.1% to 10% by weight of one or more dermal penetration enhancers selected from the group consisting of octyl salicylate and Padimate O; and (c) from 85% to 99.8% by weight of a volatile solvent selected from the group consisting of ethanol, isopropanol, and mixtures thereof; wherein the combination of testosterone and dermal penetration enhancer(s) is such that the composition, upon application and evaporation of the solvent at physiological temperatures, forms an amorphous deposit comprising an amorphous phase containing the dermal penetration enhancer(s) and testosterone.

2. A composition according to claim 1, wherein the molar ratio of testosterone to dermal penetration enhancer is from 1:20 to 20:1.

3. A composition according to claim 1, wherein the composition consists of the testosterone, the penetration enhancer(s), the volatile solvent(s) and, optionally, a gelling agent.

4. A composition according to claim 1, wherein the penetration enhancer is octyl salicylate.

5. A non-occlusive pharmaceutical composition for transdermal delivery of testosterone, consisting of: (a) from 0.1% to 10% by weight of testosterone; (b) from 0.1% to 10% by weight of one or more dermal penetration enhancers selected from the group consisting of octyl salicylate and Padimate O; and (c) from 85% to 99.8% by weight of a volatile solvent selected from the group consisting of ethanol, isopropanol, and mixtures thereof; and (d) optionally a gelling agent; wherein the combination of testosterone and dermal penetration enhancer(s) is such that the composition, upon application and evaporation of the solvent at physiological temperatures, forms an amorphous deposit comprising an amorphous phase, containing the dermal penetration enhancer(s) and testosterone.

6. A method of transdermally delivering testosterone to a subject in need thereof, comprising applying a composition according to claim 1 to the skin of the subject.

7. The method of claim 6, wherein the composition consists of the testosterone, the penetration enhancer(s), the volatile solvent(s) and, optionally, a gelling agent.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc